dc.date.accessioned | 2016-07-14T09:10:02Z | |
dc.date.available | 2016-07-14T09:10:02Z | |
dc.date.created | 2016-07-11T10:42:23Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Meyer, Haakon E Støer, Nathalie Samuelsen, Sven Ove Blomhoff, Rune Robsahm, Trude Eid Brustad, Magritt Giovannucci, Edward L Bjørge, Tone . Long Term Association between Serum 25-Hydroxyvitamin D and Mortality in a Cohort of 4379 Men. PLoS ONE. 2016, 11(3) | |
dc.identifier.uri | http://hdl.handle.net/10852/50614 | |
dc.description.abstract | Objective A number of observational studies have shown an inverse association between circulating 25-hydroxyvitamin D and total mortality, but a reverse J-shaped association has also been reported. In a large nested case-control study, serum-25-hydroxyvitamin D (s-25(OH)D) was positively associated with incident prostate cancer. Based on the same study population, the primary aim of the present study was to investigate the association between s-25(OH)D and total mortality.
Methods Men participating in population based health screenings during 1981–1991 and enrolled in a nested case-control study were followed throughout 2007 with respect to all-cause and cause-specific mortality. Hazard ratios (HR) with 95% confidence intervals (CI) were calculated using Cox proportional hazards regression.
Results In men with prostate cancer (n = 2282), there was a significant inverse association between s-25(OH)D and total mortality after controlling for potential confounders (HR = 1.25 (95% CI 1.05–1.50), s-25(OH)D <50 nmol/l versus s-25(OH)D ≥50 nmol/l). The corresponding figure among controls (n = 2147) was HR = 1.15 (95% CI 0.88–1.50) and in the total study population HR = 1.19 (95% CI 1.03–1.38). For cause-specific deaths, we found no significant associations.
Conclusions In this study population, s-25(OH)D was inversely associated with total mortality during more than two decades of follow-up, despite, as previous reported, high s-25(OH)D was associated with increased risk of prostate cancer. | en_US |
dc.language | EN | |
dc.language.iso | en | en_US |
dc.publisher | Public Library of Science (PLoS) | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Long Term Association between Serum 25-Hydroxyvitamin D and Mortality in a Cohort of 4379 Men | en_US |
dc.type | Journal article | en_US |
dc.creator.author | Meyer, Haakon E | |
dc.creator.author | Støer, Nathalie | |
dc.creator.author | Samuelsen, Sven Ove | |
dc.creator.author | Blomhoff, Rune | |
dc.creator.author | Robsahm, Trude Eid | |
dc.creator.author | Brustad, Magritt | |
dc.creator.author | Giovannucci, Edward L | |
dc.creator.author | Bjørge, Tone | |
cristin.unitcode | 185,52,14,0 | |
cristin.unitname | Avdeling for samfunnsmedisin og global helse | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1367350 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=PLoS ONE&rft.volume=11&rft.spage=&rft.date=2016 | |
dc.identifier.jtitle | PLoS ONE | |
dc.identifier.volume | 11 | |
dc.identifier.issue | 3 | |
dc.identifier.pagecount | 11 | |
dc.identifier.doi | http://dx.doi.org/10.1371/journal.pone.0151441 | |
dc.identifier.urn | URN:NBN:no-54140 | |
dc.type.document | Tidsskriftartikkel | en_US |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1932-6203 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/50614/1/Meyer_2016_Lon.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | e0151441 | |