Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1
dc.date.accessioned | 2016-04-28T09:15:10Z | |
dc.date.available | 2016-04-28T09:15:10Z | |
dc.date.created | 2016-01-18T11:50:04Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Cheng, Timothy H.T. Thompson, Deborah Painter, Jodie Omara, Tracy Gorman, Maggie Martin, Lynn Palles, Claire Jones, Angela Buchanan, Daniel D. Ko Win, Aung Hopper, John Jenkins, Mark Lindor, Noralane M. Newcomb, Polly A. Gallinger, Steve Conti, David Schumacher, Fred Casey, Graham Giles, Graham G. Pharoah, Paul Peto, Julian Cox, Angela Swerdlow, Anthony Couch, Fergus Cunningham, Julie M. Goode, Ellen L. Winham, Stacey J. Lambrechts, Diether Fasching, Peter Burwinkel, Barbara Brenner, Hermann Brauch, Hiltrud Chang-Claude, Jenny Salvesen, Helga Kristensen, Vessela N. Darabi, Hatef Li, Jingmei Liu, Tao Lindblom, Annika Hall, Per De Polanco, Magdalena Echeverry Sans, Monica Carracedo, Angel Castellvi-Bel, Sergi Rojas-Martinez, Augusto Aguiar Jnr, Samuel Teixeira, Manuel R. Dunning, Alison M. Dennis, Joe Otton, Geoffrey Proietto, Tony Holliday, Elizabeth Attia, John Ashton, Katie Scott, Rodney J. McEvoy, Mark Dowdy, Sean C. Fridley, Brooke L. Werner, Henrica Maria Johanna Trovik, Jone Njølstad, Tormund Salvesen Tham, Emma Mints, Miriam Runnebaum, Ingo Hillemanns, Peter Dörk, Thilo Amant, Frederic Schrauwen, Stefanie Hein, Alexander Beckmann, Matthias W. Ekici, Arif Czene, Kamila Meindl, Alfons Bolla, Manjeet K. Michailidou, Kyriaki Tyrer, Jonathan P. Wang, Qin Ahmed, Shahana Healey, Catherine S. Shah, Mitul Annibali, Daniela Depreeuw, Jeroen Al-Tassan, Nada A. Harris, Rebecca Meyer, Brian F Whiffin, Nicola Hosking, Fay J. Kinnersley, Ben Farrington, Susan M Timofeeva, Maria Tenesa, Albert Campbell, Harry Haile, Robert W. Hodgson, Shirley Carvajal-Carmona, Luis Cheadle, Jeremy P. Easton, Douglas Dunlop, Malcolm Houlston, Richard Spurdle, Amanda Tomlinson, Ian . Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1. Scientific Reports. 2015, 5:17369 | |
dc.identifier.uri | http://hdl.handle.net/10852/50183 | |
dc.description.abstract | High-risk mutations in several genes predispose to both colorectal cancer (CRC) and endometrial cancer (EC). We therefore hypothesised that some lower-risk genetic variants might also predispose to both CRC and EC. Using CRC and EC genome-wide association series, totalling 13,265 cancer cases and 40,245 controls, we found that the protective allele [G] at one previously-identified CRC polymorphism, rs2736100 near TERT, was associated with EC risk (odds ratio (OR) = 1.08, P = 0.000167); this polymorphism influences the risk of several other cancers. A further CRC polymorphism near TERC also showed evidence of association with EC (OR = 0.92; P = 0.03). Overall, however, there was no good evidence that the set of CRC polymorphisms was associated with EC risk, and neither of two previously-reported EC polymorphisms was associated with CRC risk. A combined analysis revealed one genome-wide significant polymorphism, rs3184504, on chromosome 12q24 (OR = 1.10, P = 7.23 × 10−9) with shared effects on CRC and EC risk. This polymorphism, a missense variant in the gene SH2B3, is also associated with haematological and autoimmune disorders, suggesting that it influences cancer risk through the immune response. Another polymorphism, rs12970291 near gene TSHZ1, was associated with both CRC and EC (OR = 1.26, P = 4.82 × 10−8), with the alleles showing opposite effects on the risks of the two cancers. | en_US |
dc.language | EN | |
dc.language.iso | en | en_US |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1 | en_US |
dc.type | Journal article | en_US |
dc.creator.author | Cheng, Timothy H.T. | |
dc.creator.author | Thompson, Deborah | |
dc.creator.author | Painter, Jodie | |
dc.creator.author | Omara, Tracy | |
dc.creator.author | Gorman, Maggie | |
dc.creator.author | Martin, Lynn | |
dc.creator.author | Palles, Claire | |
dc.creator.author | Jones, Angela | |
dc.creator.author | Buchanan, Daniel D. | |
dc.creator.author | Ko Win, Aung | |
dc.creator.author | Hopper, John | |
dc.creator.author | Jenkins, Mark | |
dc.creator.author | Lindor, Noralane M. | |
dc.creator.author | Newcomb, Polly A. | |
dc.creator.author | Gallinger, Steve | |
dc.creator.author | Conti, David | |
dc.creator.author | Schumacher, Fred | |
dc.creator.author | Casey, Graham | |
dc.creator.author | Giles, Graham G. | |
dc.creator.author | Pharoah, Paul | |
dc.creator.author | Peto, Julian | |
dc.creator.author | Cox, Angela | |
dc.creator.author | Swerdlow, Anthony | |
dc.creator.author | Couch, Fergus | |
dc.creator.author | Cunningham, Julie M. | |
dc.creator.author | Goode, Ellen L. | |
dc.creator.author | Winham, Stacey J. | |
dc.creator.author | Lambrechts, Diether | |
dc.creator.author | Fasching, Peter | |
dc.creator.author | Burwinkel, Barbara | |
dc.creator.author | Brenner, Hermann | |
dc.creator.author | Brauch, Hiltrud | |
dc.creator.author | Chang-Claude, Jenny | |
dc.creator.author | Salvesen, Helga | |
dc.creator.author | Kristensen, Vessela N. | |
dc.creator.author | Darabi, Hatef | |
dc.creator.author | Li, Jingmei | |
dc.creator.author | Liu, Tao | |
dc.creator.author | Lindblom, Annika | |
dc.creator.author | Hall, Per | |
dc.creator.author | De Polanco, Magdalena Echeverry | |
dc.creator.author | Sans, Monica | |
dc.creator.author | Carracedo, Angel | |
dc.creator.author | Castellvi-Bel, Sergi | |
dc.creator.author | Rojas-Martinez, Augusto | |
dc.creator.author | Aguiar Jnr, Samuel | |
dc.creator.author | Teixeira, Manuel R. | |
dc.creator.author | Dunning, Alison M. | |
dc.creator.author | Dennis, Joe | |
dc.creator.author | Otton, Geoffrey | |
dc.creator.author | Proietto, Tony | |
dc.creator.author | Holliday, Elizabeth | |
dc.creator.author | Attia, John | |
dc.creator.author | Ashton, Katie | |
dc.creator.author | Scott, Rodney J. | |
dc.creator.author | McEvoy, Mark | |
dc.creator.author | Dowdy, Sean C. | |
dc.creator.author | Fridley, Brooke L. | |
dc.creator.author | Werner, Henrica Maria Johanna | |
dc.creator.author | Trovik, Jone | |
dc.creator.author | Njølstad, Tormund Salvesen | |
dc.creator.author | Tham, Emma | |
dc.creator.author | Mints, Miriam | |
dc.creator.author | Runnebaum, Ingo | |
dc.creator.author | Hillemanns, Peter | |
dc.creator.author | Dörk, Thilo | |
dc.creator.author | Amant, Frederic | |
dc.creator.author | Schrauwen, Stefanie | |
dc.creator.author | Hein, Alexander | |
dc.creator.author | Beckmann, Matthias W. | |
dc.creator.author | Ekici, Arif | |
dc.creator.author | Czene, Kamila | |
dc.creator.author | Meindl, Alfons | |
dc.creator.author | Bolla, Manjeet K. | |
dc.creator.author | Michailidou, Kyriaki | |
dc.creator.author | Tyrer, Jonathan P. | |
dc.creator.author | Wang, Qin | |
dc.creator.author | Ahmed, Shahana | |
dc.creator.author | Healey, Catherine S. | |
dc.creator.author | Shah, Mitul | |
dc.creator.author | Annibali, Daniela | |
dc.creator.author | Depreeuw, Jeroen | |
dc.creator.author | Al-Tassan, Nada A. | |
dc.creator.author | Harris, Rebecca | |
dc.creator.author | Meyer, Brian F | |
dc.creator.author | Whiffin, Nicola | |
dc.creator.author | Hosking, Fay J. | |
dc.creator.author | Kinnersley, Ben | |
dc.creator.author | Farrington, Susan M | |
dc.creator.author | Timofeeva, Maria | |
dc.creator.author | Tenesa, Albert | |
dc.creator.author | Campbell, Harry | |
dc.creator.author | Haile, Robert W. | |
dc.creator.author | Hodgson, Shirley | |
dc.creator.author | Carvajal-Carmona, Luis | |
dc.creator.author | Cheadle, Jeremy P. | |
dc.creator.author | Easton, Douglas | |
dc.creator.author | Dunlop, Malcolm | |
dc.creator.author | Houlston, Richard | |
dc.creator.author | Spurdle, Amanda | |
dc.creator.author | Tomlinson, Ian | |
cristin.unitcode | 185,53,30,10 | |
cristin.unitname | Avdeling for klinisk molekylærbiologi | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1315686 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Scientific Reports&rft.volume=5:17369&rft.spage=&rft.date=2015 | |
dc.identifier.jtitle | Scientific Reports | |
dc.identifier.volume | 5:17369 | |
dc.identifier.doi | http://dx.doi.org/10.1038/srep17369 | |
dc.identifier.urn | URN:NBN:no-53828 | |
dc.type.document | Tidsskriftartikkel | en_US |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2045-2322 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/50183/1/srep17369.pdf | |
dc.type.version | PublishedVersion |
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