dc.date.accessioned | 2016-04-04T10:36:04Z | |
dc.date.available | 2016-04-04T10:36:04Z | |
dc.date.created | 2015-05-18T15:10:39Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Hodt, Anders Hisdal, Jonny Stugaard, Marie Stranden, Einar Atar, Dan Steine, Kjetil . Increased LV apical untwist during preload reduction in healthy humans. An echocardiographic speckle tracking study during lower body negative pressure (LBNP). Physiological Reports. 2015, 3 | |
dc.identifier.uri | http://hdl.handle.net/10852/50044 | |
dc.description.abstract | Background: We sought to investigate the effect of reduced preload on LV untwist and early diastolic filling in healthy individuals. Methods: Twelve healthy men, 22 (22,23) years of age, were examined at rest and during applied lower body negative pressure (LBNP) of -20 mmHg and -40 mmHg, respectively. Regional untwist and untwist rate during IVRT were calculated at LV basal, papillary, sub-papillary and apical short axis levels by two dimensional speckle tracking echocardiography. LV early diastolic filling was assessed by transmitral E-wave (E) peak velocity by pulsed Doppler and flow propagation velocity (Vp) by color M-mode Doppler and early diastolic pulsed Doppler tissue velocities (E`) from septal and lateral mitral annulus. Results: From rest to LBNP -40 mmHg the LV untwist and untwist rate at sub-papillary level increased from 2.3 (1.4,3.5) to 4.5 (3.1,7.6) degrees and from -36 (-51,-25) to -69 (-127,-42) °/s (p<0.001, p=0.003), respectively, while apical untwist and untwist rate increased from 3.9 (2.3,4.3) to 7.6 (6.4,10.5) degrees and from -51 (-69,-40) to -118 (-170,-84) °/s (p<0.001, p<0.001), respectively. Since untwist and untwist rate at the basal level were unchanged, this created markedly larger base to apical untwist and untwist rate gradients from rest to LBNP -40 mmHg. E, Vp and E` were reduced by 34, 32 and 39 %, respectively. Conclusions: LV untwist and untwist rate during IVRT were increased at apical levels, which might be a physiological mechanism to minimize the impairment in LV early diastolic filling during preload reduction. | en_US |
dc.language | EN | |
dc.language.iso | en | en_US |
dc.publisher | The Physiological Society and the American Physiological Society | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Increased LV apical untwist during preload reduction in healthy humans. An echocardiographic speckle tracking study during lower body negative pressure (LBNP) | en_US |
dc.type | Journal article | en_US |
dc.creator.author | Hodt, Anders | |
dc.creator.author | Hisdal, Jonny | |
dc.creator.author | Stugaard, Marie | |
dc.creator.author | Stranden, Einar | |
dc.creator.author | Atar, Dan | |
dc.creator.author | Steine, Kjetil | |
cristin.unitcode | 185,53,15,15 | |
cristin.unitname | Karavdelingen - Oslo vaskulære senter | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1243121 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Physiological Reports&rft.volume=3&rft.spage=&rft.date=2015 | |
dc.identifier.jtitle | Physiological Reports | |
dc.identifier.volume | 3 | |
dc.identifier.doi | http://dx.doi.org/10.14814/phy2.12330 | |
dc.identifier.urn | URN:NBN:no-53737 | |
dc.type.document | Tidsskriftartikkel | en_US |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2051-817X | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/50044/1/e12330-full.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | e12330 | |