Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949)
dc.date.accessioned | 2016-01-04T11:27:30Z | |
dc.date.available | 2016-01-04T11:27:30Z | |
dc.date.created | 2015-09-28T11:03:53Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Davies, Gail Armstrong, N Bis, JC Bressler, J Chouraki, V Giddaluru, Sudheer Hofer, E Ibrahim-Verbaas, CA Kirin, M Lahti, J Van Der Lee, SJ Le Hellard, Stephanie Liu, T Marioni, RE Oldmeadow, C Postmus, I Smith, AV Smith, JA Thalamuthu, A Thomson, R Vitart, V Wang, J Yu, L Zgaga, L Zhao, W Boxall, R Harris, SE Hill, WD Liewald, DC Luciano, M Adams, H Ames, D Amin, N Amouyel, P Assareh, AA Au, R Becker, JT Beiser, A Berr, C Bertram, L Boerwinkle, E Buckley, BM Campbell, H Corley, J De Jager, PL Dufouil, C Eriksson, JG Espeseth, Thomas Faul, JD Ford, I Scotland, Generation Gottesman, RF Griswold, ME Gudnason, V Harris, TB Heiss, G Hofman, A Holliday, EG Huffman, J Kardia, SLR Kochan, N Knopman, DS Kwok, JB Lambert, JC Lee, T Li, G Li, SC Loitfelder, M Lopez, OL Lundervold, Astri Lundqvist, A Mather, KA Mirza, SS Nyberg, L Oostra, BA Palotie, A Papenberg, G Pattie, A Petrovic, K Polasek, O Psaty, BM Redmond, P Reppermund, S Rotter, JI Schmidt, H Schuur, M Schofield, PW Scott, RJ Steen, Vidar Martin Stott, DJ Van Swieten, JC Taylor, KD Trollor, J Trompet, S Uitterlinden, AG Weinstein, G Widen, E Windham, BG Jukema, JW Wright, AF Wright, MJ Yang, Q Amieva, H Attia, JR Bennett, DA Brodaty, H De Craen, AJM Hayward, C Ikram, MA Lindenberger, U Nilsson, LG Porteous, DJ Räikkönen, K Rudan, I Sachdev, PS Schmidt, R Schofield, PR Srikanth, V Starr, JM Turner, ST Weir, DR Wilson, JF Van Duijn, C Launer, L Fitzpatrick, AL Seshadri, S Mosley, TH Deary, IJ Reinvang, Ivar . Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949). Molecular Psychiatry. 2015, 20(2), 183-192 | |
dc.identifier.uri | http://hdl.handle.net/10852/48372 | |
dc.description.abstract | General cognitive function is substantially heritable across the human life course from adolescence to old age. We investigated the genetic contribution to variation in this important, health- and well-being-related trait in middle-aged and older adults. We conducted a meta-analysis of genome-wide association studies of 31 cohorts (N=53 949) in which the participants had undertaken multiple, diverse cognitive tests. A general cognitive function phenotype was tested for, and created in each cohort by principal component analysis. We report 13 genome-wide significant single-nucleotide polymorphism (SNP) associations in three genomic regions, 6q16.1, 14q12 and 19q13.32 (best SNP and closest gene, respectively: rs10457441, P=3.93 × 10−9, MIR2113; rs17522122, P=2.55 × 10−8, AKAP6; rs10119, P=5.67 × 10−9, APOE/TOMM40). We report one gene-based significant association with the HMGN1 gene located on chromosome 21 (P=1 × 10−6). These genes have previously been associated with neuropsychiatric phenotypes. Meta-analysis results are consistent with a polygenic model of inheritance. To estimate SNP-based heritability, the genome-wide complex trait analysis procedure was applied to two large cohorts, the Atherosclerosis Risk in Communities Study (N=6617) and the Health and Retirement Study (N=5976). The proportion of phenotypic variation accounted for by all genotyped common SNPs was 29% (s.e.=5%) and 28% (s.e.=7%), respectively. Using polygenic prediction analysis, ~1.2% of the variance in general cognitive function was predicted in the Generation Scotland cohort (N=5487; P=1.5 × 10−17). In hypothesis-driven tests, there was significant association between general cognitive function and four genes previously associated with Alzheimer’s disease: TOMM40, APOE, ABCG1 and MEF2C. | en_US |
dc.language | EN | |
dc.language.iso | en | en_US |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.title | Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949) | en_US |
dc.type | Journal article | en_US |
dc.creator.author | Davies, Gail | |
dc.creator.author | Armstrong, N | |
dc.creator.author | Bis, JC | |
dc.creator.author | Bressler, J | |
dc.creator.author | Chouraki, V | |
dc.creator.author | Giddaluru, Sudheer | |
dc.creator.author | Hofer, E | |
dc.creator.author | Ibrahim-Verbaas, CA | |
dc.creator.author | Kirin, M | |
dc.creator.author | Lahti, J | |
dc.creator.author | Van Der Lee, SJ | |
dc.creator.author | Le Hellard, Stephanie | |
dc.creator.author | Liu, T | |
dc.creator.author | Marioni, RE | |
dc.creator.author | Oldmeadow, C | |
dc.creator.author | Postmus, I | |
dc.creator.author | Smith, AV | |
dc.creator.author | Smith, JA | |
dc.creator.author | Thalamuthu, A | |
dc.creator.author | Thomson, R | |
dc.creator.author | Vitart, V | |
dc.creator.author | Wang, J | |
dc.creator.author | Yu, L | |
dc.creator.author | Zgaga, L | |
dc.creator.author | Zhao, W | |
dc.creator.author | Boxall, R | |
dc.creator.author | Harris, SE | |
dc.creator.author | Hill, WD | |
dc.creator.author | Liewald, DC | |
dc.creator.author | Luciano, M | |
dc.creator.author | Adams, H | |
dc.creator.author | Ames, D | |
dc.creator.author | Amin, N | |
dc.creator.author | Amouyel, P | |
dc.creator.author | Assareh, AA | |
dc.creator.author | Au, R | |
dc.creator.author | Becker, JT | |
dc.creator.author | Beiser, A | |
dc.creator.author | Berr, C | |
dc.creator.author | Bertram, L | |
dc.creator.author | Boerwinkle, E | |
dc.creator.author | Buckley, BM | |
dc.creator.author | Campbell, H | |
dc.creator.author | Corley, J | |
dc.creator.author | De Jager, PL | |
dc.creator.author | Dufouil, C | |
dc.creator.author | Eriksson, JG | |
dc.creator.author | Espeseth, Thomas | |
dc.creator.author | Faul, JD | |
dc.creator.author | Ford, I | |
dc.creator.author | Scotland, Generation | |
dc.creator.author | Gottesman, RF | |
dc.creator.author | Griswold, ME | |
dc.creator.author | Gudnason, V | |
dc.creator.author | Harris, TB | |
dc.creator.author | Heiss, G | |
dc.creator.author | Hofman, A | |
dc.creator.author | Holliday, EG | |
dc.creator.author | Huffman, J | |
dc.creator.author | Kardia, SLR | |
dc.creator.author | Kochan, N | |
dc.creator.author | Knopman, DS | |
dc.creator.author | Kwok, JB | |
dc.creator.author | Lambert, JC | |
dc.creator.author | Lee, T | |
dc.creator.author | Li, G | |
dc.creator.author | Li, SC | |
dc.creator.author | Loitfelder, M | |
dc.creator.author | Lopez, OL | |
dc.creator.author | Lundervold, Astri | |
dc.creator.author | Lundqvist, A | |
dc.creator.author | Mather, KA | |
dc.creator.author | Mirza, SS | |
dc.creator.author | Nyberg, L | |
dc.creator.author | Oostra, BA | |
dc.creator.author | Palotie, A | |
dc.creator.author | Papenberg, G | |
dc.creator.author | Pattie, A | |
dc.creator.author | Petrovic, K | |
dc.creator.author | Polasek, O | |
dc.creator.author | Psaty, BM | |
dc.creator.author | Redmond, P | |
dc.creator.author | Reppermund, S | |
dc.creator.author | Rotter, JI | |
dc.creator.author | Schmidt, H | |
dc.creator.author | Schuur, M | |
dc.creator.author | Schofield, PW | |
dc.creator.author | Scott, RJ | |
dc.creator.author | Steen, Vidar Martin | |
dc.creator.author | Stott, DJ | |
dc.creator.author | Van Swieten, JC | |
dc.creator.author | Taylor, KD | |
dc.creator.author | Trollor, J | |
dc.creator.author | Trompet, S | |
dc.creator.author | Uitterlinden, AG | |
dc.creator.author | Weinstein, G | |
dc.creator.author | Widen, E | |
dc.creator.author | Windham, BG | |
dc.creator.author | Jukema, JW | |
dc.creator.author | Wright, AF | |
dc.creator.author | Wright, MJ | |
dc.creator.author | Yang, Q | |
dc.creator.author | Amieva, H | |
dc.creator.author | Attia, JR | |
dc.creator.author | Bennett, DA | |
dc.creator.author | Brodaty, H | |
dc.creator.author | De Craen, AJM | |
dc.creator.author | Hayward, C | |
dc.creator.author | Ikram, MA | |
dc.creator.author | Lindenberger, U | |
dc.creator.author | Nilsson, LG | |
dc.creator.author | Porteous, DJ | |
dc.creator.author | Räikkönen, K | |
dc.creator.author | Rudan, I | |
dc.creator.author | Sachdev, PS | |
dc.creator.author | Schmidt, R | |
dc.creator.author | Schofield, PR | |
dc.creator.author | Srikanth, V | |
dc.creator.author | Starr, JM | |
dc.creator.author | Turner, ST | |
dc.creator.author | Weir, DR | |
dc.creator.author | Wilson, JF | |
dc.creator.author | Van Duijn, C | |
dc.creator.author | Launer, L | |
dc.creator.author | Fitzpatrick, AL | |
dc.creator.author | Seshadri, S | |
dc.creator.author | Mosley, TH | |
dc.creator.author | Deary, IJ | |
dc.creator.author | Reinvang, Ivar | |
cristin.unitcode | 185,53,10,70 | |
cristin.unitname | NORMENT part UiO | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 1275878 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Molecular Psychiatry&rft.volume=20&rft.spage=183&rft.date=2015 | |
dc.identifier.jtitle | Molecular Psychiatry | |
dc.identifier.volume | 20 | |
dc.identifier.issue | 2 | |
dc.identifier.startpage | 183 | |
dc.identifier.endpage | 192 | |
dc.identifier.doi | http://dx.doi.org/10.1038/mp.2014.188 | |
dc.identifier.urn | URN:NBN:no-52288 | |
dc.subject.nvi | VDP::Kognitiv psykologi: 267VDP::Medisinsk genetikk: 714 | |
dc.type.document | Tidsskriftartikkel | en_US |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1359-4184 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/48372/2/mp2014188a.pdf | |
dc.type.version | PublishedVersion |
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