Browsing Det matematisk-naturvitenskapelige fakultet by Author "Fan, Chun-Chieh"

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  • Beyond SNP heritability: Polygenicity and discoverability of phenotypes estimated with a univariate Gaussian mixture model 
    Holland, Dominic; Frei, Oleksandr; Desikan, Rahul S.; Fan, Chun-Chieh; Shadrin, Alexey A.; Smeland, Olav Bjerkehagen; Sundar, Vijay S.; Thompson, Paul; Andreassen, Ole Andreas; Dale, Anders M. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Estimating the polygenicity (proportion of causally associated single nucleotide polymorphisms (SNPs)) and discoverability (effect size variance) of causal SNPs for human traits is currently of considerable interest. ...
  • Characterising the shared genetic determinants of bipolar disorder, schizophrenia and risk-taking 
    Hindley, Guy Frederick Lanyon; Bahrami, Shahram; Steen, Nils Eiel; O'Connell, Kevin Sean; Frei, Oleksandr; Shadrin, Alexey; Bettella, Francesco; Rødevand, Linn; Fan, Chun-Chieh; Dale, Anders; Djurovic, Srdjan; Smeland, Olav Bjerkehagen; Andreassen, Ole (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Abstract Increased risk-taking is a central component of bipolar disorder (BIP) and is implicated in schizophrenia (SCZ). Risky behaviours, including smoking and alcohol use, are overrepresented in both disorders and ...