dc.date.accessioned | 2015-11-09T15:38:59Z | |
dc.date.available | 2015-11-09T15:38:59Z | |
dc.date.created | 2012-12-18T08:39:48Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Cuypers, Koenraad Loos, Ruth J.F. Kvaløy, Kirsti Kulle, Bettina Romundstad, Pål Richard Holmen, Turid Lingaas . Obesity-Susceptibility Loci and Their Influence on Adiposity-Related Traits in Transition from Adolescence to Adulthood - The HUNT Study. PLoS ONE. 2012, 7(10) | |
dc.identifier.uri | http://hdl.handle.net/10852/47631 | |
dc.description.abstract | Introduction Obesity-susceptibility loci have been related to adiposity traits in adults and may affect body fat estimates in adolescence. There are indications that different sets of obesity-susceptibility loci influence level of and change in obesity-related traits from adolescence to adulthood.
Objectives To investigate whether previously reported obesity-susceptible loci in adults influence adiposity traits in adolescence and change in BMI and waist circumference (WC) from adolescence into young adulthood. We also examined whether physical activity modifies the effects of these genetic loci on adiposity-related traits.
Methods Nine obesity-susceptibility variants were genotyped in 1 643 adolescents (13–19 years old) from the HUNT study, Norway, who were followed-up into young adulthood. Lifestyle was assessed using questionnaires and anthropometric measurements were taken. The effects of genetic variants individually and combined in a genetic predisposition score (GPS) on obesity-related traits were studied cross-sectionally and longitudinally. A modifying effect of physical activity was tested.
Results The GPS was significantly associated to BMI (B: 0.046 SD/allele [0.020, 0.073], p = 0.001) in adolescence and in young adulthood (B: 0.041 SD/allele [0.015, 0.067], p = 0.002) as it was to waist circumference (WC). The GPS was not associated to change in BMI (p = 0.762) or WC (p = 0.726). We found no significant interaction effect between the GPS and physical activity.
Conclusions Our observations suggest that obesity-susceptibility loci established in adults affect BMI and WC already in adolescence. However, an association with change in adiposity-related traits from adolescence to adulthood could not be verified for these loci. Neither could an attenuating effect of physical activity on
© Cuypers et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | en_US |
dc.language | EN | |
dc.language.iso | en | en_US |
dc.publisher | Public Library of Science (PLoS) | |
dc.title | Obesity-Susceptibility Loci and Their Influence on Adiposity-Related Traits in Transition from Adolescence to Adulthood - The HUNT Study | en_US |
dc.type | Journal article | en_US |
dc.creator.author | Cuypers, Koenraad | |
dc.creator.author | Loos, Ruth J.F. | |
dc.creator.author | Kvaløy, Kirsti | |
dc.creator.author | Kulle, Bettina | |
dc.creator.author | Romundstad, Pål Richard | |
dc.creator.author | Holmen, Turid Lingaas | |
cristin.unitcode | 185,53,30,10 | |
cristin.unitname | Avdeling for klinisk molekylærbiologi | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 974695 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=PLoS ONE&rft.volume=7&rft.spage=&rft.date=2012 | |
dc.identifier.jtitle | PLoS ONE | |
dc.identifier.volume | 7 | |
dc.identifier.issue | 10 | |
dc.identifier.pagecount | 8 | |
dc.identifier.doi | http://dx.doi.org/10.1371/journal.pone.0046912 | |
dc.identifier.urn | URN:NBN:no-51674 | |
dc.type.document | Tidsskriftartikkel | en_US |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1932-6203 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/47631/1/fetchObject17777.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | e46912 | |