dc.date.accessioned | 2015-09-08T12:23:19Z | |
dc.date.available | 2015-09-08T12:23:19Z | |
dc.date.created | 2015-09-07T17:12:55Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Bergan, Harald Arne Halvorsen, Per Steinar Skulstad, Helge Edvardsen, Thor Fosse, Erik Bugge, Jan F . Successful ECMO-cardiopulmonary resuscitation with the associated post-arrest cardiac dysfunction as demonstrated by MRI. Intensive Care Medicine Experimental. 2015, 3 | |
dc.identifier.uri | http://hdl.handle.net/10852/45829 | |
dc.description.abstract | Background Veno-arterial extracorporeal membrane oxygenation (ECMO-CPR) is a life-saving rescue for selected patients when standard cardiopulmonary resuscitation fails. The use is increasing although the treatment modality is not fully established. Resuscitated patients typically develop a detrimental early post-arrest cardiac dysfunction that also deserves main emphasis. The present study investigates an ECMO-CPR strategy in pigs and assesses early post-arrest left ventricular function in detail. We hypothesised that a significant dysfunction could be demonstrated with this model using magnetic resonance imaging (MRI), not previously used early post-arrest.
Methods In eight anaesthetised pigs, a 15-min ventricular fibrillation was resuscitated by an ECMO-CPR strategy of 150-min veno-arterial ECMO aiming at high blood flow rate and pharmacologically sustained aortic blood pressure and pulse pressure of 50 and 15 mmHg, respectively. Pre-arrest cardiac MRI and haemodynamic measurements of left ventricular function were compared to measurements performed 300-min post-arrest.
Results All animals were successfully resuscitated, weaned from the ECMO circuit, and haemodynamically stabilised post-arrest. Cardiac output was maintained by an increased heart rate post-arrest, but left ventricular ejection fraction and stroke volume were decreased by approximately 50 %. Systolic circumferential strain and mitral annular plane systolic excursion as well as the left ventricular wall thickening were reduced by approximately 50–70 % post-arrest. The diastolic function variables measured were unchanged.
Conclusions The present animal study demonstrates a successful ECMO-CPR strategy resuscitating long-lasting cardiac arrest with adequate post-arrest haemodynamic stability. The associated severe systolic left ventricular dysfunction could be charted in detail by MRI, a valuable tool for future cardiac outcome assessments in resuscitation research. | en_US |
dc.language | EN | |
dc.language.iso | en | en_US |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.title | Successful ECMO-cardiopulmonary resuscitation with the associated post-arrest cardiac dysfunction as demonstrated by MRI | en_US |
dc.type | Journal article | en_US |
dc.creator.author | Bergan, Harald Arne | |
dc.creator.author | Halvorsen, Per Steinar | |
dc.creator.author | Skulstad, Helge | |
dc.creator.author | Edvardsen, Thor | |
dc.creator.author | Fosse, Erik | |
dc.creator.author | Bugge, Jan F | |
cristin.unitcode | 185,50,0,0 | |
cristin.unitname | Det medisinske fakultet | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1262443 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Intensive Care Medicine Experimental&rft.volume=3&rft.spage=&rft.date=2015 | |
dc.identifier.jtitle | Intensive Care Medicine Experimental | |
dc.identifier.volume | 3 | |
dc.identifier.doi | http://dx.doi.org/10.1186/s40635-015-0061-2 | |
dc.identifier.urn | URN:NBN:no-50050 | |
dc.type.document | Tidsskriftartikkel | en_US |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2197-425X | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/45829/1/s40635-015-0061-2-1.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | 25 | |