The genome sequence of Atlantic cod reveals a unique immune system
dc.date.accessioned | 2015-08-28T09:29:59Z | |
dc.date.available | 2015-08-28T09:29:59Z | |
dc.date.created | 2011-08-24T14:44:01Z | |
dc.date.issued | 2011 | |
dc.identifier.citation | Star, Bastiaan Nederbragt, Alexander Johan Jentoft, Sissel Grimholt, Unni Malmstrøm, Martin Gregers, Tone Fredsvik Rounge, Trine Ballestad Paulsen, Jonas Solbakken, Monica Hongrø Sharma, Animesh Wetten, Ola Frang Lanzén, Anders Winer, Roger Knight, James Vogel, Jan-Hinnerk Aken, Bronwen Andersen, Øivind Lagesen, Karin Tooming-Klunderud, Ave Edvardsen, Rolf Kirubakaran, G. Tina Espelund, Mari Nepal, Chirag Previti, A. Christopher Karlsen, Bård Ove Moum, Truls Skage, Morten Berg, Paul Ragnar Gjøen, Tor Kuhl, Heiner Thorsen, Jim Malde, Ketil Reinhardt, Richard Du, Lei Johansen, Steinar Daae Searle, Steve Lien, Sigbjørn Nilsen, Frank Jonassen, Inge Omholt, Stig W Stenseth, Nils Christian Jakobsen, Kjetill Sigurd . The genome sequence of Atlantic cod reveals a unique immune system. Nature. 2011, 477(7363), 207-210 | |
dc.identifier.uri | http://hdl.handle.net/10852/45244 | |
dc.description.abstract | Atlantic cod (Gadus morhua) is a large, cold-adapted teleost that sustains long-standing commercial fisheries and incipient aquaculture. Here we present the genome sequence of Atlantic cod, showing evidence for complex thermal adaptations in its haemoglobin gene cluster and an unusual immune architecture compared to other sequenced vertebrates. The genome assembly was obtained exclusively by 454 sequencing of shotgun and paired-end libraries, and automated annotation identified 22,154 genes. The major histocompatibility complex (MHC)?II is a conserved feature of the adaptive immune system of jawed vertebrates, but we show that Atlantic cod has lost the genes for MHC?II, CD4 and invariant chain (Ii) that are essential for the function of this pathway. Nevertheless, Atlantic cod is not exceptionally susceptible to disease under natural conditions. We find a highly expanded number of MHC?I genes and a unique composition of its Toll-like receptor (TLR) families. This indicates how the Atlantic cod immune system has evolved compensatory mechanisms in both adaptive and innate immunity in the absence of MHC?II. These observations affect fundamental assumptions about the evolution of the adaptive immune system and its components in vertebrates. | en_US |
dc.language | EN | |
dc.language.iso | en | en_US |
dc.publisher | Macmillan Publishers Ltd. | |
dc.rights | Attribution-NonCommercial-ShareAlike 3.0 Unported | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/ | |
dc.title | The genome sequence of Atlantic cod reveals a unique immune system | en_US |
dc.type | Journal article | en_US |
dc.creator.author | Star, Bastiaan | |
dc.creator.author | Nederbragt, Alexander Johan | |
dc.creator.author | Jentoft, Sissel | |
dc.creator.author | Grimholt, Unni | |
dc.creator.author | Malmstrøm, Martin | |
dc.creator.author | Gregers, Tone Fredsvik | |
dc.creator.author | Rounge, Trine Ballestad | |
dc.creator.author | Paulsen, Jonas | |
dc.creator.author | Solbakken, Monica Hongrø | |
dc.creator.author | Sharma, Animesh | |
dc.creator.author | Wetten, Ola Frang | |
dc.creator.author | Lanzén, Anders | |
dc.creator.author | Winer, Roger | |
dc.creator.author | Knight, James | |
dc.creator.author | Vogel, Jan-Hinnerk | |
dc.creator.author | Aken, Bronwen | |
dc.creator.author | Andersen, Øivind | |
dc.creator.author | Lagesen, Karin | |
dc.creator.author | Tooming-Klunderud, Ave | |
dc.creator.author | Edvardsen, Rolf | |
dc.creator.author | Kirubakaran, G. Tina | |
dc.creator.author | Espelund, Mari | |
dc.creator.author | Nepal, Chirag | |
dc.creator.author | Previti, A. Christopher | |
dc.creator.author | Karlsen, Bård Ove | |
dc.creator.author | Moum, Truls | |
dc.creator.author | Skage, Morten | |
dc.creator.author | Berg, Paul Ragnar | |
dc.creator.author | Gjøen, Tor | |
dc.creator.author | Kuhl, Heiner | |
dc.creator.author | Thorsen, Jim | |
dc.creator.author | Malde, Ketil | |
dc.creator.author | Reinhardt, Richard | |
dc.creator.author | Du, Lei | |
dc.creator.author | Johansen, Steinar Daae | |
dc.creator.author | Searle, Steve | |
dc.creator.author | Lien, Sigbjørn | |
dc.creator.author | Nilsen, Frank | |
dc.creator.author | Jonassen, Inge | |
dc.creator.author | Omholt, Stig W | |
dc.creator.author | Stenseth, Nils Christian | |
dc.creator.author | Jakobsen, Kjetill Sigurd | |
cristin.unitcode | 185,15,21,90 | |
cristin.unitname | Centre for Ecological and Evolutionary Synthesis | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2A | |
dc.identifier.cristin | 834476 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature&rft.volume=477&rft.spage=207&rft.date=2011 | |
dc.identifier.jtitle | Nature | |
dc.identifier.volume | 477 | |
dc.identifier.issue | 7363 | |
dc.identifier.startpage | 207 | |
dc.identifier.endpage | 210 | |
dc.identifier.doi | http://dx.doi.org/10.1038/nature10342 | |
dc.identifier.urn | URN:NBN:no-49486 | |
dc.subject.nvi | VDP::Genetikk og genomikk: 474 | |
dc.type.document | Tidsskriftartikkel | en_US |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0028-0836 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/45244/1/Karlsen.pdf | |
dc.type.version | PublishedVersion |
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