Browsing Kjemisk institutt by Author "Würth-Roderer, Kathrin"
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Fahrig-Kamarauskaitė, Jūratė; Würth-Roderer, Kathrin; Thorbjørnsrud, Helen Vikdal; Mailand, Susanne; Krengel, Ute; Kast, Peter (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)Chorismate mutase (CM), an essential enzyme at the branch-point of the shikimate pathway, is required for the biosynthesis of phenylalanine and tyrosine in bacteria, archaea, plants, and fungi. MtCM, the CM from Mycobacterium ...
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Stocker, Christian; Khatanbaatar, Tamjidmaa; Bressan, Luca; Würth-Roderer, Kathrin; Cordara, Gabriele; Krengel, Ute; Kast, Peter (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)Chorismate mutase (CM) and cyclohexadienyl dehydratase (CDT) catalyze two subsequent reactions in the intracellular biosynthesis of l-phenylalanine (Phe). Here, we report the discovery of novel and extremely rare bifunctional ...
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Thorbjørnsrud, Helen Vikdal; Bressan, Lucas; Khatanbaatar, Tamjidmaa; Carrer, Manuel; Würth-Roderer, Kathrin; Cordara, Gabriele; Kast, Peter; Cascella, Michele; Krengel, Ute (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)Unlike typical chorismate mutases, the enzyme from Mycobacterium tuberculosis (MtCM) has only low activity on its own. Remarkably, its catalytic efficiency kcat/Km can be boosted more than 100-fold by complex formation ...