Browsing Kjemisk institutt by Author "Thorbjørnsrud, Helen Vikdal"

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  • Evolving the naturally compromised chorismate mutase from Mycobacterium tuberculosis to top performance 
    Fahrig-Kamarauskaitė, Jūratė; Würth-Roderer, Kathrin; Thorbjørnsrud, Helen Vikdal; Mailand, Susanne; Krengel, Ute; Kast, Peter (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Chorismate mutase (CM), an essential enzyme at the branch-point of the shikimate pathway, is required for the biosynthesis of phenylalanine and tyrosine in bacteria, archaea, plants, and fungi. MtCM, the CM from Mycobacterium ...
  • Inter-Enzyme Allosteric Regulation of Chorismate Mutase in Corynebacterium glutamicum: Structural Basis of Feedback Activation by Trp 
    Burschowsky, Daniel; Thorbjørnsrud, Helen Vikdal; Heim, Joel Benjamin; Fahrig-Kamarauskaite, Jurate; Würth-Roderer, Kathrin; Kast, Peter; Krengel, Ute (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)
    Corynebacterium glutamicum is widely used for the industrial production of amino acids, nucleotides, and vitamins. The shikimate pathway enzymes DAHP synthase (CgDS, Cg2391) and chorismate mutase (CgCM, Cgl0853) play a key ...
  • What Drives Chorismate Mutase to Top Performance? Insights from a Combined In Silico and In Vitro Study 
    Thorbjørnsrud, Helen Vikdal; Bressan, Lucas; Khatanbaatar, Tamjidmaa; Carrer, Manuel; Würth-Roderer, Kathrin; Cordara, Gabriele; Kast, Peter; Cascella, Michele; Krengel, Ute (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Unlike typical chorismate mutases, the enzyme from Mycobacterium tuberculosis (MtCM) has only low activity on its own. Remarkably, its catalytic efficiency kcat/Km can be boosted more than 100-fold by complex formation ...