Browsing Kjemisk institutt by Author "Sekulic, Nikolina"

Now showing items 1-5 of 5

  • CENP-A and CENP-B collaborate to create an open centromeric chromatin state 
    Nagpal, Harsh; Ali Ahmad, Ahmad; Hirano, Yasuhiro; Cai, Wei; Halic, Mario; Fukagawa, Tatsuo; Sekulic, Nikolina; Fierz, Beat (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Centromeres are epigenetically defined via the presence of the histone H3 variant CENP-A. Contacting CENP-A nucleosomes, the constitutive centromere associated network (CCAN) and the kinetochore assemble, connecting the ...
  • CENP‐C unwraps the human CENP‐A nucleosome through the H2A C‐terminal tail 
    Ali Ahmad, Ahmad; Bilokapic, Silvija; Schafer, Ingmar B; Halic, Mario; Sekulic, Nikolina (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Centromeres are defined epigenetically by nucleosomes containing the histone H3 variant CENP ‐A, upon which the constitutive centromere‐associated network of proteins (CCAN ) is built. CENP ‐C is considered to be a central ...
  • Development of a High-Affinity Antibody against the Tumor-Specific and Hyperactive 611-p95HER2 Isoform 
    Dorraji, Seyed Esmaeil; Borgen, Elin; Segura-Pena, Dario; Rawat, Puneet; Smorodina, Eva; Dunn, Claire; Greiff, Victor; Sekulic, Nikolina; Russnes, Hege Elisabeth Giercksky; Kyte, Jon A (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Simple Summary In the present study, we addressed the unmet need for a molecular antibody (mAb) with high affinity and specificity against a truncated hyperactive isoform of human epidermal growth factor receptor 2 (HER2), ...
  • Requirement of PP2A-B56 Par1 for the Stabilization of the CDK Inhibitor Rum1 and Activation of APC/C Ste9 during Pre-Start G1 in S. pombe 
    Stonyte, Vilte; Martîn, Ruth Martîn; Segura-Pena, Dario; Sekulic, Nikolina; Lopez Aviles, Sandra (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Exit from the cell cycle during the establishment of quiescence and upon cell differentiation requires the sustained inactivation of CDK complexes. Fission yeast cells deprived of nitrogen halt cell cycle progression in ...
  • The structural basis of the multi-step allosteric activation of Aurora B kinase 
    Segura Pena, Dario; Hovet, Oda; Gogoi, Hemanga; Dawicki-Mckenna, Jennine; Wøien, Stine Malene Hansen; Carrer, Manuel; Black, Ben E.; Cascella, Michele; Sekulic, Nikolina (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Aurora B, together with IN-box, the C-terminal part of INCENP, forms an enzymatic complex that ensures faithful cell division. The [Aurora B/IN-box] complex is activated by autophosphorylation in the Aurora B activation ...