Browsing Kjemisk institutt by Author "Nielsen, Josefine Eilsø"

Now showing items 1-9 of 9

  • A biophysical study of the interactions between the antimicrobial peptide indolicidin and lipid model systems 
    Nielsen, Josefine Eilsø; Lind, Tania Kjellerup; Lone, Abdullah; Gerelli, Yuri; Hansen, Paul Robert; Jenssen, Håvard; Cardenas, Marite; Lund, Reidar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    The naturally occurring peptide indolicidin from bovine neutrophils exhibits strong biological activity against a broad spectrum of microorganisms. This is believed to arise from selective interactions with the negatively ...
  • Accelerating Lipid Flip-Flop at Low Concentrations: A General Mechanism for Membrane Binding Peptides 
    Carrer, Manuel; Nielsen, Josefine Eilsø; Musseli Cezar, Henrique; Lund, Reidar; Cascella, Michele; Soares da Silva, Thereza Amelia (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    We report a physicochemical investigation of the lipid transport properties of model lipid membranes in the presence of the antimicrobial peptide indolicidin through comparisons of experimental SANS/SAXS scattering techniques ...
  • Beyond structural models for the mode of action: How natural antimicrobial peptides affect lipid transport 
    Nielsen, Josefine Eilsø; Bjørnestad, Victoria Ariel; Pipich, Vitaliy; Jenssen, Håvard; Lund, Reidar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Hypothesis: Most textbook models for antimicrobial peptides (AMP) mode of action are focused on structural effects and pore formation in lipid membranes, while these deformations have been shown to require high concentrations ...
  • Examining the Molecular Mechanism of Antimicrobial Peptides using Neutron and X-ray Scattering Techniques 
    Nielsen, Josefine Eilsø (Doctoral thesis / Doktoravhandling, 2020)
    Antimicrobial peptides (AMPs) are found in Nature as a part of the innate immune system in a wide range of species, including humans. Because of the emerging concern of widespread antibiotic resistance new antibiotics are ...
  • Halogenation as a tool to tune antimicrobial activity of peptoids 
    Molchanova, Natalia; Nielsen, Josefine Eilsø; Sørensen, Kristian B; Krishna, Bala; Hansen, Paul Robert; Lund, Reidar; Barron, Annelise E.; Jenssen, Håvard (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Abstract Antimicrobial peptides have attracted considerable interest as potential new class of antibiotics against multi-drug resistant bacteria. However, their therapeutic potential is limited, in part due to ...
  • Molecular Transport and Growth of Lipid Vesicles Exposed to Antimicrobial Peptides 
    Nielsen, Josefine Eilsø; Lund, Reidar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    It is well-known that lipids constituting the cytoplasmic membrane undergo continuous reorganization to maintain the appropriate composition important for the integrity of the cell. The transport of lipids is controlled ...
  • Peptide meets membrane: Investigating peptide-lipid interactions using small-angle scattering techniques 
    Nielsen, Josefine Eilsø; Koynarev, Vladimir Rosenov; Lund, Reidar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Peptide–lipid interactions play an important role in defining the mode of action of drugs and the molecular mechanism associated with many diseases. Model membranes consisting of simple lipid mixtures mimicking real cell ...
  • Real-Time Monitoring of Multitarget Antimicrobial Mechanisms of Peptoids Using Label-Free Imaging with Optical Diffraction Tomography 
    Kim, Minsang; Cheon, Yeongmi; Shin, Dongmin; Choi, Jieun; Nielsen, Josefine Eilsø; Jeong, Myeong Seon; Nam, Ho Yeon; Kim, Sung-Hak; Lund, Reidar; Jenssen, Håvard; Barron, Annelise E.; Lee, Seongsoo; Seo, Jiwon (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Abstract Antimicrobial peptides (AMPs) are promising therapeutics in the fight against multidrug‐resistant bacteria. As a mimic of AMPs, peptoids with N ‐substituted glycine backbone have been utilized for antimicrobials ...
  • Stability of Nanopeptides: Structure and Molecular Exchange of Self-assembled Peptide Fibers 
    König, Nico; Szostak, Szymon Mikolaj; Nielsen, Josefine Eilsø; Dunbar, Martha; Yang, Su; Chen, Weike; Benjamin, Ari; Radulescu, Aurel; Mahmoudi, Najet; Willner, Lutz; Keten, Sinan; Dong, He; Lund, Reidar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Often nanostructures formed by self-assembly of small molecules based on hydrophobic interactions are rather unstable, causing morphological changes or even dissolution when exposed to changes in aqueous media. In contrast, ...