Browsing Kjemisk institutt by Author "Aizenshtadt, Aleksandra"

Now showing items 1-6 of 6

  • Direct Electromembrane Extraction based Mass Spectrometry: A Tool for Studying Drug Metabolism Properties of Liver Organoids 
    Wilson, Steven Ray Haakon; Krauss, Stefan Johannes Karl; Lundanes, Elsa; Skottvoll, Frøydis Sved; Bogen, Inger Lise; Pedersen-Bjergaard, Stig; Hansen, Frederik; Aizenshtadt, Aleksandra; Kutter, Jörg P.; Andersen, Jannike Mørch; Martinez, Mikel Amirola (Journal article / Tidsskriftartikkel / PublishedVersion, 2021)
    This work introduces a strategy for organoid analysis - direct Electromembrane Extraction based Mass Spectrometry (dEME-MS) – for coupling liver organoids with mass spectrometry (MS). dEME-MS comprises electrophoresis of ...
  • Electromembrane extraction and mass spectrometry for liver organoid drug metabolism studies 
    Skottvoll, Frøydis Sved; Hansen, Frederik; Harrison, Sean; Boger, Ida Caroline Sneis; Mrsa, Ago; Restan, Magnus Saed; Stein, Matthias; Lundanes, Elsa; Pedersen-Bjergaard, Stig; Aizenshtadt, Aleksandra; Krauss, Stefan; Sullivan, Gareth; Bogen, Inger Lise; Wilson, Steven Ray Haakon (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Liver organoids are emerging tools for precision drug development and toxicity screening. We demonstrate that electromembrane extraction (EME) based on electrophoresis across an oil membrane is suited for segregating ...
  • Mass spectrometry reveals that oxysterols are secreted from non-alcoholic fatty liver disease induced organoids 
    Kømurcu, Kristina Sæterdal; Wilhelmsen, Ingrid; Thorne, James L.; Krauss, Stefan Johannes Karl; Wilson, Steven Ray Haakon; Aizenshtadt, Aleksandra; Røberg-Larsen, Hanne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Oxysterols are potential biomarkers for liver metabolism that are altered under disease conditions such as non-alcoholic fatty liver disease (NAFLD). We here apply sterolomics to organoids used for disease modeling of ...
  • "Organ-in-a-Column" Coupled On-line with Liquid Chromatography-Mass Spectrometry 
    Kogler, Stian; Aizenshtadt, Aleksandra; Harrison, Sean; Skottvoll, Frøydis Sved; Berg, Henriette Engen; Abadpour, Shadab; Scholz, Hanne; Sullivan, Gareth John; Thiede, Bernd; Lundanes, Elsa; Bogen, Inger Lise; Krauss, Stefan Johannes Karl; Røberg-Larsen, Hanne; Wilson, Steven Ray Haakon (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Organoids, i.e., laboratory-grown organ models developed from stem cells, are emerging tools for studying organ physiology, disease modeling, and drug development. On-line analysis of organoids with mass spectrometry would ...
  • Quantitative chemometric phenotyping of three-dimensional liver organoids by Raman spectral imaging 
    LaLone, Vernon; Aizenshtadt, Aleksandra; Goertz, John; Skottvoll, Frøydis Sved; Mota, Marco Barbero; You, Junji; Zhao, Xiaoyu; Berg, Henriette Engen; Stokowiec, Justyna; Yu, Minzhi; Schwendeman, Anna; Scholz, Hanne; Wilson, Steven Ray Haakon; Krauss, Stefan Johannes Karl; Stevens, Molly M. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Confocal Raman spectral imaging (RSI) enables high-content, label-free visualization of a wide range of molecules in biological specimens without sample preparation. However, reliable quantification of the deconvoluted ...
  • Simultaneous LC–MS determination of glucose regulatory peptides secreted by stem cell–derived islet organoids 
    Olsen, Christine; Wang, Chencheng; Aizenshtadt, Aleksandra; Abadpour, Shadab; Lundanes, Elsa; Skottvoll, Frøydis Sved; Golovin, Alexey; Busek, Mathias; Krauss, Stefan Johannes Karl; Scholz, Hanne; Wilson, Steven Ray Haakon (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Abstract For studying stem cell–derived islet organoids (SC‐islets) in an organ‐on‐chip (OoC) platform, we have developed a reversed‐phase liquid chromatography–tandem mass spectrometry (RPLC–MS/MS) method allowing for ...