Browsing Kjemisk institutt by Author "Lund, Reidar"

Now showing items 1-20 of 21

  • A biophysical study of the interactions between the antimicrobial peptide indolicidin and lipid model systems 
    Nielsen, Josefine Eilsø; Lind, Tania Kjellerup; Lone, Abdullah; Gerelli, Yuri; Hansen, Paul Robert; Jenssen, Håvard; Cardenas, Marite; Lund, Reidar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    The naturally occurring peptide indolicidin from bovine neutrophils exhibits strong biological activity against a broad spectrum of microorganisms. This is believed to arise from selective interactions with the negatively ...
  • A poly-proline II helix in YadA from Yersinia enterocolitica serotype O:9 facilitates heparin binding through electrostatic interactions 
    Meuskens, Ina; Kristiansen, Per Eugen; Bardiaux, Benjamin; Koynarev, Vladimir Rosenov; Hatlem, Daniel; Prydz, Kristian; Lund, Reidar; Izadi-Pruneyre, Nadia; Linke, Dirk (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2024)
    Poly‐proline II helices are secondary structure motifs frequently found in ligand‐binding sites. They exhibit increased flexibility and solvent exposure compared to the strongly hydrogen‐bonded α‐helices or β‐strands and ...
  • A trimeric coiled-coil motif binds bacterial lipopolysaccharides with picomolar affinity 
    Hatlem, Daniel; Christensen, Mikkel; Broeker, Nina; Kristiansen, Per Eugen; Lund, Reidar; Barbirz, Stefanie; Linke, Dirk (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    α-helical coiled-coils are ubiquitous protein structures in all living organisms. For decades, modified coiled-coils sequences have been used in biotechnology, vaccine development, and biochemical research to induce protein ...
  • Absorption of CO2 in lyotropic liquid crystals 
    Rodriguez Fabia, Sandra; Øyen, Marita; Winter-Hjelm, Nicolai; Norrman, Jens; Lund, Reidar; Sørland, Geir; Knuutila, Hanna; Sjøblom, Johan; Paso, Kristofer Gunnar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Vapor–liquid equilibria data of three poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide)/water liquid crystals (LCs) with CO2 has been obtained up to 6 bar. The investigated LCs consist of 60% (EO)3(PO)50(EO)3 ...
  • Accelerating Lipid Flip-Flop at Low Concentrations: A General Mechanism for Membrane Binding Peptides 
    Carrer, Manuel; Nielsen, Josefine Eilsø; Musseli Cezar, Henrique; Lund, Reidar; Cascella, Michele; Soares da Silva, Thereza Amelia (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    We report a physicochemical investigation of the lipid transport properties of model lipid membranes in the presence of the antimicrobial peptide indolicidin through comparisons of experimental SANS/SAXS scattering techniques ...
  • Beyond structural models for the mode of action: How natural antimicrobial peptides affect lipid transport 
    Nielsen, Josefine Eilsø; Bjørnestad, Victoria Ariel; Pipich, Vitaliy; Jenssen, Håvard; Lund, Reidar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Hypothesis: Most textbook models for antimicrobial peptides (AMP) mode of action are focused on structural effects and pore formation in lipid membranes, while these deformations have been shown to require high concentrations ...
  • Beyond the standard model of solubilization: Non-ionic surfactants induce collapse of lipid vesicles into rippled bilamellar nanodiscs 
    Bjørnestad, Victoria Ariel; Soto-Bustamante, Fernando; Tria, Giancarlo; Laurati, Marco; Lund, Reidar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Hypothesis Although solubilization of lipid membranes has been studied extensively, questions remain regarding the structural pathways and metastable structures involved. This study investigated whether the non-ionic ...
  • Cooperativity during Melting and Molecular Exchange in Micelles with Crystalline Cores 
    König, Nico; Willner, Lutz; Pipich, Vitaliy; Zinn, Thomas; Lund, Reidar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Molecular exchange processes are important equilibration and transport mechanisms in both synthetic and biological self-assembled systems such as micelles, vesicles, and membranes. Still, these processes are not entirely ...
  • Halogenation as a tool to tune antimicrobial activity of peptoids 
    Molchanova, Natalia; Nielsen, Josefine Eilsø; Sørensen, Kristian B; Krishna, Bala; Hansen, Paul Robert; Lund, Reidar; Barron, Annelise E.; Jenssen, Håvard (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Abstract Antimicrobial peptides have attracted considerable interest as potential new class of antibiotics against multi-drug resistant bacteria. However, their therapeutic potential is limited, in part due to ...
  • How detergents dissolve polymeric micelles: Kinetic pathways of hybrid micelle formation in SDS and block copolymer mixtures 
    Myhre, Synne; Amann, Matthias; Willner, Lutz; Knudsen, Kenneth Dahl; Lund, Reidar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Mixtures of amphiphilic polymers and surfactants are used in a wide range of applications, e.g., pharmaceuticals, detergents, cosmetics, and drug delivery systems. Still, many questions remain on how the structure and, in ...
  • Micelle kinetics of photoswitchable surfactants: Self-assembly pathways and relaxation mechanisms 
    Bjørnestad, Victoria Ariel; Li, Xinmeng; Tribet, Christophe; Lund, Reidar; Cascella, Michele (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Hypothesis: A key question in the kinetics of surfactant self-assembly is whether exchange of unimers or fusion/fission of entire micelles is the dominant pathway. In this study, an isomerizable surfactant is used to explore ...
  • Molecular Transport and Growth of Lipid Vesicles Exposed to Antimicrobial Peptides 
    Nielsen, Josefine Eilsø; Lund, Reidar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    It is well-known that lipids constituting the cytoplasmic membrane undergo continuous reorganization to maintain the appropriate composition important for the integrity of the cell. The transport of lipids is controlled ...
  • Nanoscopic confinement through self-assembly: Crystallization within micellar cores exhibits simple Gibbs-Thomson behavior 
    Zinn, Thomas; Willner, Lutz; Lund, Reidar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
    It is well known that liquids confined to small nanoscopic pores and droplets exhibit thermal behavior very different from bulk samples. Less is known about liquids spontaneously confined through self-assembly into micellar ...
  • Pathways of Membrane Solubilization: A Structural Study of Model Lipid Vesicles Exposed to Classical Detergents 
    Bjørnestad, Victoria Ariel; Lund, Reidar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Understanding the pathways of solubilization of lipid membranes is of high importance for their use in biotechnology and industrial applications. Although lipid vesicle solubilization by classical detergents has been widely ...
  • Peptide meets membrane: Investigating peptide-lipid interactions using small-angle scattering techniques 
    Nielsen, Josefine Eilsø; Koynarev, Vladimir Rosenov; Lund, Reidar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Peptide–lipid interactions play an important role in defining the mode of action of drugs and the molecular mechanism associated with many diseases. Model membranes consisting of simple lipid mixtures mimicking real cell ...
  • Real-Time Monitoring of Multitarget Antimicrobial Mechanisms of Peptoids Using Label-Free Imaging with Optical Diffraction Tomography 
    Kim, Minsang; Cheon, Yeongmi; Shin, Dongmin; Choi, Jieun; Nielsen, Josefine Eilsø; Jeong, Myeong Seon; Nam, Ho Yeon; Kim, Sung-Hak; Lund, Reidar; Jenssen, Håvard; Barron, Annelise E.; Lee, Seongsoo; Seo, Jiwon (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Abstract Antimicrobial peptides (AMPs) are promising therapeutics in the fight against multidrug‐resistant bacteria. As a mimic of AMPs, peptoids with N ‐substituted glycine backbone have been utilized for antimicrobials ...
  • Spherical Micelles with Nonspherical Cores: Effect of Chain Packing on the Micellar Shape 
    König, Nico; Willner, Lutz; Carlström, Göran; Zinn, Thomas; Knudsen, Kenneth Dahl; Rise, Frode; Topgaard, Daniel; Lund, Reidar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Self-assembly of amphiphilic polymers into micelles is an archetypical example of a “self-confined” system due to the formation of micellar cores with dimensions of a few nanometers. In this work, we investigate the chain ...
  • Stability of Nanopeptides: Structure and Molecular Exchange of Self-assembled Peptide Fibers 
    König, Nico; Szostak, Szymon Mikolaj; Nielsen, Josefine Eilsø; Dunbar, Martha; Yang, Su; Chen, Weike; Benjamin, Ari; Radulescu, Aurel; Mahmoudi, Najet; Willner, Lutz; Keten, Sinan; Dong, He; Lund, Reidar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Often nanostructures formed by self-assembly of small molecules based on hydrophobic interactions are rather unstable, causing morphological changes or even dissolution when exposed to changes in aqueous media. In contrast, ...
  • Supramolecular Packing Drives Morphological Transitions of Charged Surfactant Micelles 
    Schäfer, Ken; Kolli, Hima Bindu; Christensen, Mikkel Killingmoe; Bore, Sigbjørn Løland; Diezemann, Gregor; Gauss, Jürgen; Milano, Giuseppe; Lund, Reidar; Cascella, Michele (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    The shape and size of self‐assembled structures upon local organization of their molecular building blocks are hard to predict in the presence of long‐range interactions. Combining small‐angle X‐ray/neutron scattering data, ...
  • Tale of Two Tails: Molecular Exchange Kinetics of Telechelic Polymer Micelles 
    König, Nico; Willner, Lutz; Pipich, Vitaliy; Mahmoudi, Najet; Lund, Reidar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Telechelic polymers contain two chain ends that are able to promote self-assembly into “flowerlike” or interconnected micellar structures. Here, we investigate the molecular exchange kinetics of such micelles using ...