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dc.date.accessioned2015-04-15T10:22:56Z
dc.date.available2015-04-15T10:22:56Z
dc.date.created2015-01-29T15:47:51Z
dc.date.issued2014
dc.identifier.citationReichborn-Kjennerud, Ted Knudsen, Gun Peggy Andreassen, Ole Andreas Espeseth, Thomas Lundervold, Astri Reinvang, Ivar Steen, Vidar Martin Le Hellard, Stephanie Mattingsdal, Morten Boraske, V Franklin, CS Floyd, James A. B. Thornton, Laura M Huckins, L. M. Southam, L Rayner, NW Tachmazidou, I Klump, KL Treasure, Jim Lewis, C. M. Schmidt, U Tozzi, F Kiezebrink, K Hebebrand, J. Gorwood, P. Adan, R. A. H. Kas, M. J. H. Favaro, A Santonastaso, P Fernández-Aranda, Fernando Gratacòs, Mònica Rybakowski, Finn Dmitrzak-Weglarz, M. Kaprio, J Keski-Rahkonen, A Raevuori, A. Van Furth, E. F. Slof-Op 't Landt, M. C. T. Hudson, JI Monteleone, P. Kaplan, AS Karwautz, A Hakonarson, H Berrettini, W. H. Guo, Y Li, D Schork, NJ Komaki, G Ando, T Inoko, H. . A genome-wide association study of anorexia nervosa. Molecular Psychiatry. 2014, 19(10), 1085-1094
dc.identifier.urihttp://hdl.handle.net/10852/43575
dc.description.abstractAnorexia nervosa (AN) is a complex and heritable eating disorder characterized by dangerously low body weight. Neither candidate gene studies nor an initial genome-wide association study (GWAS) have yielded significant and replicated results. We performed a GWAS in 2907 cases with AN from 14 countries (15 sites) and 14 860 ancestrally matched controls as part of the Genetic Consortium for AN (GCAN) and the Wellcome Trust Case Control Consortium 3 (WTCCC3). Individual association analyses were conducted in each stratum and meta-analyzed across all 15 discovery data sets. Seventy-six (72 independent) single nucleotide polymorphisms were taken forward for in silico (two data sets) or de novo (13 data sets) replication genotyping in 2677 independent AN cases and 8629 European ancestry controls along with 458 AN cases and 421 controls from Japan. The final global meta-analysis across discovery and replication data sets comprised 5551 AN cases and 21 080 controls. AN subtype analyses (1606 AN restricting; 1445 AN binge–purge) were performed. No findings reached genome-wide significance. Two intronic variants were suggestively associated: rs9839776 (P=3.01 × 10−7) in SOX2OT and rs17030795 (P=5.84 × 10−6) in PPP3CA. Two additional signals were specific to Europeans: rs1523921 (P=5.76 × 10−6) between CUL3 and FAM124B and rs1886797 (P=8.05 × 10−6) near SPATA13. Comparing discovery with replication results, 76% of the effects were in the same direction, an observation highly unlikely to be due to chance (P=4 × 10−6), strongly suggesting that true findings exist but our sample, the largest yet reported, was underpowered for their detection. The accrual of large genotyped AN case-control samples should be an immediate priority for the field.en_US
dc.languageEN
dc.language.isoenen_US
dc.titleA genome-wide association study of anorexia nervosaen_US
dc.typeJournal articleen_US
dc.creator.authorReichborn-Kjennerud, Ted
dc.creator.authorKnudsen, Gun Peggy
dc.creator.authorAndreassen, Ole Andreas
dc.creator.authorEspeseth, Thomas
dc.creator.authorLundervold, Astri
dc.creator.authorReinvang, Ivar
dc.creator.authorSteen, Vidar Martin
dc.creator.authorLe Hellard, Stephanie
dc.creator.authorMattingsdal, Morten
dc.creator.authorBoraske, V
dc.creator.authorFranklin, CS
dc.creator.authorFloyd, James A. B.
dc.creator.authorThornton, Laura M
dc.creator.authorHuckins, L. M.
dc.creator.authorSoutham, L
dc.creator.authorRayner, NW
dc.creator.authorTachmazidou, I
dc.creator.authorKlump, KL
dc.creator.authorTreasure, Jim
dc.creator.authorLewis, C. M.
dc.creator.authorSchmidt, U
dc.creator.authorTozzi, F
dc.creator.authorKiezebrink, K
dc.creator.authorHebebrand, J.
dc.creator.authorGorwood, P.
dc.creator.authorAdan, R. A. H.
dc.creator.authorKas, M. J. H.
dc.creator.authorFavaro, A
dc.creator.authorSantonastaso, P
dc.creator.authorFernández-Aranda, Fernando
dc.creator.authorGratacòs, Mònica
dc.creator.authorRybakowski, Finn
dc.creator.authorDmitrzak-Weglarz, M.
dc.creator.authorKaprio, J
dc.creator.authorKeski-Rahkonen, A
dc.creator.authorRaevuori, A.
dc.creator.authorVan Furth, E. F.
dc.creator.authorSlof-Op 't Landt, M. C. T.
dc.creator.authorHudson, JI
dc.creator.authorMonteleone, P.
dc.creator.authorKaplan, AS
dc.creator.authorKarwautz, A
dc.creator.authorHakonarson, H
dc.creator.authorBerrettini, W. H.
dc.creator.authorGuo, Y
dc.creator.authorLi, D
dc.creator.authorSchork, NJ
dc.creator.authorKomaki, G
dc.creator.authorAndo, T
dc.creator.authorInoko, H.
cristin.unitcode185,53,10,14
cristin.unitnameEnhet voksenpsykiatri
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2
dc.identifier.cristin1211503
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Molecular Psychiatry&rft.volume=19&rft.spage=1085&rft.date=2014
dc.identifier.jtitleMolecular Psychiatry
dc.identifier.volume19
dc.identifier.issue10
dc.identifier.startpage1085
dc.identifier.endpage1094
dc.identifier.doihttp://dx.doi.org/10.1038/mp.2013.187
dc.identifier.urnURN:NBN:no-47938
dc.subject.nviVDP::Medisinsk genetikk: 714
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn1359-4184
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/43575/1/A%2Bgenome-wide%2Bassociation%2Bstudy%2Bof%2Banorexia%2Bnervosa.pdf
dc.type.versionAcceptedVersion


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