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Biological insights from 108 schizophrenia-associated genetic loci

dc.date.accessioned2015-04-15T10:05:47Z
dc.date.available2015-04-15T10:05:47Z
dc.date.created2014-09-19T08:31:01Z
dc.date.issued2014
dc.identifier.citationRipke, Stephan Neale, B Corvin, A Walters, JTR Farh, KH Holmans, PA Lee, P Bulik-Sullivan, B Collier, DA Huang, H Pers, TH Agartz, Ingrid Agerbo, E Albus, M Alexander, M Amin, F Bacanu, SA Begemann, M Belliveau, RA Bene, J Bergen, SE Bevilacqua, E Bigdeli, TB Black, DW Bruggeman, R Buccola, NG Buckner, RL Byerley, W Cahn, W Cai, G Campion, D Cantor, RM Carr, VJ Carrera, N Catts, SV Chambert, KD Chan, RCK Chen, RYL Chen, EYH Cheng, W Cheung, EFC Chong, SA Cloninger, CR Cohen, D Cohen, N Cormican, P Craddock, N Crowley, JJ Curtis, D Davidson, M Davis, KL Degenhardt, F Del Favero, J Demontis, D Dikeos, D Dinan, T Djurovic, Srdjan Donohoe, G Drapeau, E Duan, J Dudbridge, F Durmishi, N Eichhammer, P Eriksson, J Escott-Price, V Essioux, L Fanous, AH Farrell, MS Frank, J Franke, L Freedman, R Freimer, NB Friedl, M Friedman, JI Fromer, M Genovese, G Georgieva, L Giegling, I Giusti-Rodriguez, P Godard, S Goldstein, JI Golimbet, V Gopal, S Gratten, J De Haan, L Hammer, C Hamshere, ML Hansen, M Hansen, T Haroutunian, V Hartmann, AM Henskens, FA Herms, S Hirschhorn, JN Hoffmann, P Hofman, A Hollegaard, MV Hougaard, DM Ikeda, M Joa, Inge Julia, A Kahn, RS Kalaydjieva, L Karachanak-Yankova, S Karjalainen, J Kavanagh, D Keller, MC Kennedy, JL Khrunin, A Kim, Y Klovins, J Knowles, JA Konte, B Kucinskas, V Kucinskiene, ZA Kuzelova-Ptackova, H Kahler, AK Laurent, C Keong, JLC Lee, SH Legge, SE Lerer, B Li, M Li, T Liang, KY Lieberman, J Limborska, S Loughland, CM Lubinski, J Lonnqvist, J Macek, M Magnusson, PKE Maher, BS Maier, W Mallet, J Marsal, S Mattheisen, M Mattingsdal, Morten McCarley, RW McDonald, C McIntosh, AM Meier, S Meijer, CJ Melegh, B Melle, Ingrid Mesholam-Gately, RI Metspalu, A Michie, PT Milani, L Milanova, V Mokrab, Y Morris, DW Mors, O Murphy, KC Murray, RM Myin-Germeys, I Muller-Myhsok, B Nelis, M Nenadic, I Nertney, DA Nestadt, G Nicodemus, KK Nikitina-Zake, L Nisenbaum, L Nordin, A O'Callaghan, E O'Dushlaine, C O'Neill, FA Oh, SY Olincy, A Olsen, L Van Os, J Pantelis, C Papadimitriou, GN Papiol, S Parkhomenko, E Pato, MT Paunio, T Pejovic-Milovancevic, M Perkins, DO Pietilainen, O Pimm, J Pocklington, AJ Powell, J Price, A Pulver, AE Purcell, SM Quested, D Rasmussen, HB Reichenberg, A Reimers, MA Richards, AL Roffman, JL Roussos, P Ruderfer, DM Salomaa, V Sanders, AR Schall, U Schubert, CR Schulze, TG Schwab, SG Scolnick, EM Scott, RJ Seidman, LJ Shi, J Sigurdsson, E Silagadze, T Silverman, JM Sim, K Slominsky, P Smoller, JW So, HC Spencer, CCA Stahl, EA Stefansson, H Steinberg, S Stogmann, E Straub, RE Strengman, E Strohmaier, J Stroup, TS Subramaniam, M Suvisaari, J Svrakic, DM Szatkiewicz, JP Soderman, E Thirumalai, S Toncheva, D Tosato, S Veijola, J Waddington, J Walsh, D Wang, D Wang, Q Webb, BT Weiser, M Wildenauer, DB Williams, NM Williams, S Witt, SH Wolen, AR Wong, EHM Wormley, BK Xi, HS Zai, CC Zheng, X Zimprich, F Wray, NR Stefansson, K Visscher, PM Adolfsson, R Andreassen, Ole Andreas Blackwood, DHR Bramon, E Buxbaum, JD Børglum, AD Cichon, S Darvasi, A Domenici, E Ehrenreich, H Esko, T Gejman, PV Gill, M Gurling, H Hultman, CM Iwata, N Jablensky, AV Jönsson, Erik Gunnar Kendler, KS Kirov, G Knight, J Lencz, T Levinson, DF Li, QS Liu, J Malhotra, AK McCarroll, SA McQuillin, A Moran, JL Mortensen, PB Mowry, BJ Nothen, MM Ophoff, RA Owen, MJ Palotie, A Pato, CN Petryshen, TL Posthuma, D Rietschel, M Riley, BP Rujescu, D Sham, PC Sklar, P St Clair, D Weinberger, DR Wendland, JR Werge, T Daly, MJ Sullivan, PF O'Donovan, MC . Biological insights from 108 schizophrenia-associated genetic loci. Nature. 2014, 511(7510), 421-427
dc.identifier.urihttp://hdl.handle.net/10852/43574
dc.description.abstractSchizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here we report a multi-stage schizophrenia genome-wide association study of up to 36,989 cases and 113,075 controls. We identify 128 independent associations spanning 108 conservatively defined loci that meet genome-wide significance, 83 of which have not been previously reported. Associations were enriched among genes expressed in brain, providing biological plausibility for the findings. Many findings have the potential to provide entirely new insights into aetiology, but associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Independent of genes expressed in brain, associations were enriched among genes expressed in tissues that have important roles in immunity, providing support for the speculated link between the immune system and schizophrenia.en_US
dc.languageEN
dc.language.isoenen_US
dc.publisherMacmillan Publishers Ltd.
dc.titleBiological insights from 108 schizophrenia-associated genetic locien_US
dc.typeJournal articleen_US
dc.creator.authorRipke, Stephan
dc.creator.authorNeale, B
dc.creator.authorCorvin, A
dc.creator.authorWalters, JTR
dc.creator.authorFarh, KH
dc.creator.authorHolmans, PA
dc.creator.authorLee, P
dc.creator.authorBulik-Sullivan, B
dc.creator.authorCollier, DA
dc.creator.authorHuang, H
dc.creator.authorPers, TH
dc.creator.authorAgartz, Ingrid
dc.creator.authorAgerbo, E
dc.creator.authorAlbus, M
dc.creator.authorAlexander, M
dc.creator.authorAmin, F
dc.creator.authorBacanu, SA
dc.creator.authorBegemann, M
dc.creator.authorBelliveau, RA
dc.creator.authorBene, J
dc.creator.authorBergen, SE
dc.creator.authorBevilacqua, E
dc.creator.authorBigdeli, TB
dc.creator.authorBlack, DW
dc.creator.authorBruggeman, R
dc.creator.authorBuccola, NG
dc.creator.authorBuckner, RL
dc.creator.authorByerley, W
dc.creator.authorCahn, W
dc.creator.authorCai, G
dc.creator.authorCampion, D
dc.creator.authorCantor, RM
dc.creator.authorCarr, VJ
dc.creator.authorCarrera, N
dc.creator.authorCatts, SV
dc.creator.authorChambert, KD
dc.creator.authorChan, RCK
dc.creator.authorChen, RYL
dc.creator.authorChen, EYH
dc.creator.authorCheng, W
dc.creator.authorCheung, EFC
dc.creator.authorChong, SA
dc.creator.authorCloninger, CR
dc.creator.authorCohen, D
dc.creator.authorCohen, N
dc.creator.authorCormican, P
dc.creator.authorCraddock, N
dc.creator.authorCrowley, JJ
dc.creator.authorCurtis, D
dc.creator.authorDavidson, M
dc.creator.authorDavis, KL
dc.creator.authorDegenhardt, F
dc.creator.authorDel Favero, J
dc.creator.authorDemontis, D
dc.creator.authorDikeos, D
dc.creator.authorDinan, T
dc.creator.authorDjurovic, Srdjan
dc.creator.authorDonohoe, G
dc.creator.authorDrapeau, E
dc.creator.authorDuan, J
dc.creator.authorDudbridge, F
dc.creator.authorDurmishi, N
dc.creator.authorEichhammer, P
dc.creator.authorEriksson, J
dc.creator.authorEscott-Price, V
dc.creator.authorEssioux, L
dc.creator.authorFanous, AH
dc.creator.authorFarrell, MS
dc.creator.authorFrank, J
dc.creator.authorFranke, L
dc.creator.authorFreedman, R
dc.creator.authorFreimer, NB
dc.creator.authorFriedl, M
dc.creator.authorFriedman, JI
dc.creator.authorFromer, M
dc.creator.authorGenovese, G
dc.creator.authorGeorgieva, L
dc.creator.authorGiegling, I
dc.creator.authorGiusti-Rodriguez, P
dc.creator.authorGodard, S
dc.creator.authorGoldstein, JI
dc.creator.authorGolimbet, V
dc.creator.authorGopal, S
dc.creator.authorGratten, J
dc.creator.authorDe Haan, L
dc.creator.authorHammer, C
dc.creator.authorHamshere, ML
dc.creator.authorHansen, M
dc.creator.authorHansen, T
dc.creator.authorHaroutunian, V
dc.creator.authorHartmann, AM
dc.creator.authorHenskens, FA
dc.creator.authorHerms, S
dc.creator.authorHirschhorn, JN
dc.creator.authorHoffmann, P
dc.creator.authorHofman, A
dc.creator.authorHollegaard, MV
dc.creator.authorHougaard, DM
dc.creator.authorIkeda, M
dc.creator.authorJoa, Inge
dc.creator.authorJulia, A
dc.creator.authorKahn, RS
dc.creator.authorKalaydjieva, L
dc.creator.authorKarachanak-Yankova, S
dc.creator.authorKarjalainen, J
dc.creator.authorKavanagh, D
dc.creator.authorKeller, MC
dc.creator.authorKennedy, JL
dc.creator.authorKhrunin, A
dc.creator.authorKim, Y
dc.creator.authorKlovins, J
dc.creator.authorKnowles, JA
dc.creator.authorKonte, B
dc.creator.authorKucinskas, V
dc.creator.authorKucinskiene, ZA
dc.creator.authorKuzelova-Ptackova, H
dc.creator.authorKahler, AK
dc.creator.authorLaurent, C
dc.creator.authorKeong, JLC
dc.creator.authorLee, SH
dc.creator.authorLegge, SE
dc.creator.authorLerer, B
dc.creator.authorLi, M
dc.creator.authorLi, T
dc.creator.authorLiang, KY
dc.creator.authorLieberman, J
dc.creator.authorLimborska, S
dc.creator.authorLoughland, CM
dc.creator.authorLubinski, J
dc.creator.authorLonnqvist, J
dc.creator.authorMacek, M
dc.creator.authorMagnusson, PKE
dc.creator.authorMaher, BS
dc.creator.authorMaier, W
dc.creator.authorMallet, J
dc.creator.authorMarsal, S
dc.creator.authorMattheisen, M
dc.creator.authorMattingsdal, Morten
dc.creator.authorMcCarley, RW
dc.creator.authorMcDonald, C
dc.creator.authorMcIntosh, AM
dc.creator.authorMeier, S
dc.creator.authorMeijer, CJ
dc.creator.authorMelegh, B
dc.creator.authorMelle, Ingrid
dc.creator.authorMesholam-Gately, RI
dc.creator.authorMetspalu, A
dc.creator.authorMichie, PT
dc.creator.authorMilani, L
dc.creator.authorMilanova, V
dc.creator.authorMokrab, Y
dc.creator.authorMorris, DW
dc.creator.authorMors, O
dc.creator.authorMurphy, KC
dc.creator.authorMurray, RM
dc.creator.authorMyin-Germeys, I
dc.creator.authorMuller-Myhsok, B
dc.creator.authorNelis, M
dc.creator.authorNenadic, I
dc.creator.authorNertney, DA
dc.creator.authorNestadt, G
dc.creator.authorNicodemus, KK
dc.creator.authorNikitina-Zake, L
dc.creator.authorNisenbaum, L
dc.creator.authorNordin, A
dc.creator.authorO'Callaghan, E
dc.creator.authorO'Dushlaine, C
dc.creator.authorO'Neill, FA
dc.creator.authorOh, SY
dc.creator.authorOlincy, A
dc.creator.authorOlsen, L
dc.creator.authorVan Os, J
dc.creator.authorPantelis, C
dc.creator.authorPapadimitriou, GN
dc.creator.authorPapiol, S
dc.creator.authorParkhomenko, E
dc.creator.authorPato, MT
dc.creator.authorPaunio, T
dc.creator.authorPejovic-Milovancevic, M
dc.creator.authorPerkins, DO
dc.creator.authorPietilainen, O
dc.creator.authorPimm, J
dc.creator.authorPocklington, AJ
dc.creator.authorPowell, J
dc.creator.authorPrice, A
dc.creator.authorPulver, AE
dc.creator.authorPurcell, SM
dc.creator.authorQuested, D
dc.creator.authorRasmussen, HB
dc.creator.authorReichenberg, A
dc.creator.authorReimers, MA
dc.creator.authorRichards, AL
dc.creator.authorRoffman, JL
dc.creator.authorRoussos, P
dc.creator.authorRuderfer, DM
dc.creator.authorSalomaa, V
dc.creator.authorSanders, AR
dc.creator.authorSchall, U
dc.creator.authorSchubert, CR
dc.creator.authorSchulze, TG
dc.creator.authorSchwab, SG
dc.creator.authorScolnick, EM
dc.creator.authorScott, RJ
dc.creator.authorSeidman, LJ
dc.creator.authorShi, J
dc.creator.authorSigurdsson, E
dc.creator.authorSilagadze, T
dc.creator.authorSilverman, JM
dc.creator.authorSim, K
dc.creator.authorSlominsky, P
dc.creator.authorSmoller, JW
dc.creator.authorSo, HC
dc.creator.authorSpencer, CCA
dc.creator.authorStahl, EA
dc.creator.authorStefansson, H
dc.creator.authorSteinberg, S
dc.creator.authorStogmann, E
dc.creator.authorStraub, RE
dc.creator.authorStrengman, E
dc.creator.authorStrohmaier, J
dc.creator.authorStroup, TS
dc.creator.authorSubramaniam, M
dc.creator.authorSuvisaari, J
dc.creator.authorSvrakic, DM
dc.creator.authorSzatkiewicz, JP
dc.creator.authorSoderman, E
dc.creator.authorThirumalai, S
dc.creator.authorToncheva, D
dc.creator.authorTosato, S
dc.creator.authorVeijola, J
dc.creator.authorWaddington, J
dc.creator.authorWalsh, D
dc.creator.authorWang, D
dc.creator.authorWang, Q
dc.creator.authorWebb, BT
dc.creator.authorWeiser, M
dc.creator.authorWildenauer, DB
dc.creator.authorWilliams, NM
dc.creator.authorWilliams, S
dc.creator.authorWitt, SH
dc.creator.authorWolen, AR
dc.creator.authorWong, EHM
dc.creator.authorWormley, BK
dc.creator.authorXi, HS
dc.creator.authorZai, CC
dc.creator.authorZheng, X
dc.creator.authorZimprich, F
dc.creator.authorWray, NR
dc.creator.authorStefansson, K
dc.creator.authorVisscher, PM
dc.creator.authorAdolfsson, R
dc.creator.authorAndreassen, Ole Andreas
dc.creator.authorBlackwood, DHR
dc.creator.authorBramon, E
dc.creator.authorBuxbaum, JD
dc.creator.authorBørglum, AD
dc.creator.authorCichon, S
dc.creator.authorDarvasi, A
dc.creator.authorDomenici, E
dc.creator.authorEhrenreich, H
dc.creator.authorEsko, T
dc.creator.authorGejman, PV
dc.creator.authorGill, M
dc.creator.authorGurling, H
dc.creator.authorHultman, CM
dc.creator.authorIwata, N
dc.creator.authorJablensky, AV
dc.creator.authorJönsson, Erik Gunnar
dc.creator.authorKendler, KS
dc.creator.authorKirov, G
dc.creator.authorKnight, J
dc.creator.authorLencz, T
dc.creator.authorLevinson, DF
dc.creator.authorLi, QS
dc.creator.authorLiu, J
dc.creator.authorMalhotra, AK
dc.creator.authorMcCarroll, SA
dc.creator.authorMcQuillin, A
dc.creator.authorMoran, JL
dc.creator.authorMortensen, PB
dc.creator.authorMowry, BJ
dc.creator.authorNothen, MM
dc.creator.authorOphoff, RA
dc.creator.authorOwen, MJ
dc.creator.authorPalotie, A
dc.creator.authorPato, CN
dc.creator.authorPetryshen, TL
dc.creator.authorPosthuma, D
dc.creator.authorRietschel, M
dc.creator.authorRiley, BP
dc.creator.authorRujescu, D
dc.creator.authorSham, PC
dc.creator.authorSklar, P
dc.creator.authorSt Clair, D
dc.creator.authorWeinberger, DR
dc.creator.authorWendland, JR
dc.creator.authorWerge, T
dc.creator.authorDaly, MJ
dc.creator.authorSullivan, PF
dc.creator.authorO'Donovan, MC
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cristin.fulltextoriginal
cristin.qualitycode2A
dc.identifier.cristin1155878
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature&rft.volume=511&rft.spage=421&rft.date=2014
dc.identifier.jtitleNature
dc.identifier.volume511
dc.identifier.issue7510
dc.identifier.startpage421
dc.identifier.endpage427
dc.identifier.doihttp://dx.doi.org/10.1038/nature13595
dc.identifier.urnURN:NBN:no-47934
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn0028-0836
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/43574/1/Biological%2Binsights%2Bfrom%2B108%2Bschizophrenia-associated%2Bgenetic%2Bloci.pdf
dc.type.versionAcceptedVersion


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