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Common variant at 16p11.2 conferring risk of psychosis

dc.date.accessioned2015-04-15T09:02:24Z
dc.date.available2015-04-15T09:02:24Z
dc.date.created2014-05-06T20:21:21Z
dc.date.issued2014
dc.identifier.citationSteinberg, Stacy de Jong, S Mattheisen, M Costas, J Demontis, D Jamain, S Pietilainen, OPH Lin, K Papiol, S Huttenlocher, J Sigurdsson, E Vassos, E Giegling, I Breuer, R Fraser, G Walker, N Melle, Ingrid Djurovic, Srdjan Agartz, Ingrid Tuulio-Henriksson, A Suvisaari, J Lonnqvist, J Paunio, T Olsen, L Hansen, T Ingason, A Pirinen, M Strengman, E Hougaard, DM Orntoft, T Didriksen, M Hollegaard, MV Nordentoft, M Abramova, L Kaleda, V Arrojo, M Sanjuan, J Arango, C Etain, B Bellivier, F Meary, A Schurhoff, F Szoke, A Ribolsi, M Magni, V Siracusano, A Sperling, S Rossner, M Christiansen, C Kiemeney, LA Franke, B van den Berg, LH Veldink, J Curran, S Bolton, P Poot, M Staal, W Rehnstrom, K Kilpinen, H Freitag, CM Meyer, J Magnusson, P Saemundsen, E Martsenkovsky, I Bikshaieva, I Martsenkovska, I Vashchenko, O Raleva, M Paketchieva, K Stefanovski, B Durmishi, N Milovancevic, MP Tosevski, DL Silagadze, T Naneishvili, N Mikeladze, N Surguladze, S Vincent, JB Farmer, A Mitchell, PB Wright, A Schofield, PR Fullerton, JM Montgomery, GW Martin, NG Rubino, IA van Winkel, R Kenis, G De Hert, M Rethelyi, JM Bitter, I Terenius, L Jonsson, EG Bakker, S van Os, J Jablensky, A Leboyer, M Bramon, E Powell, J Murray, R Corvin, A Gill, M Morris, D O'Neill, FA Kendler, K Riley, B Craddock, N Owen, MJ O'Donovan, MC Thorsteinsdottir, U Kong, A Ehrenreich, H Carracedo, A Golimbet, V Andreassen, Ole Andreas Borglum, AD Mors, O Mortensen, PB Werge, T Ophoff, RA Nothen, MM Rietschel, M Cichon, S Ruggeri, M Tosato, S Palotie, A St Clair, D Rujescu, D Collier, DA Stefansson, H Stefánsson, Kári . Common variant at 16p11.2 conferring risk of psychosis. Molecular Psychiatry. 2014, 19, 108-114
dc.identifier.urihttp://hdl.handle.net/10852/43572
dc.description.abstractEpidemiological and genetic data support the notion that schizophrenia and bipolar disorder share genetic risk factors. In our previous genome-wide association study, meta-analysis and follow-up (totaling as many as 18 206 cases and 42 536 controls), we identified four loci showing genome-wide significant association with schizophrenia. Here we consider a mixed schizophrenia and bipolar disorder (psychosis) phenotype (addition of 7469 bipolar disorder cases, 1535 schizophrenia cases, 333 other psychosis cases, 808 unaffected family members and 46 160 controls). Combined analysis reveals a novel variant at 16p11.2 showing genome-wide significant association (rs4583255[T]; odds ratio=1.08; P=6.6 × 10(-11)). The new variant is located within a 593-kb region that substantially increases risk of psychosis when duplicated. In line with the association of the duplication with reduced body mass index (BMI), rs4583255[T] is also associated with lower BMI (P=0.0039 in the public GIANT consortium data set; P=0.00047 in 22 651 additional Icelanders).
dc.languageEN
dc.titleCommon variant at 16p11.2 conferring risk of psychosis
dc.typeJournal article
dc.creator.authorSteinberg, Stacy
dc.creator.authorde Jong, S
dc.creator.authorMattheisen, M
dc.creator.authorCostas, J
dc.creator.authorDemontis, D
dc.creator.authorJamain, S
dc.creator.authorPietilainen, OPH
dc.creator.authorLin, K
dc.creator.authorPapiol, S
dc.creator.authorHuttenlocher, J
dc.creator.authorSigurdsson, E
dc.creator.authorVassos, E
dc.creator.authorGiegling, I
dc.creator.authorBreuer, R
dc.creator.authorFraser, G
dc.creator.authorWalker, N
dc.creator.authorMelle, Ingrid
dc.creator.authorDjurovic, Srdjan
dc.creator.authorAgartz, Ingrid
dc.creator.authorTuulio-Henriksson, A
dc.creator.authorSuvisaari, J
dc.creator.authorLonnqvist, J
dc.creator.authorPaunio, T
dc.creator.authorOlsen, L
dc.creator.authorHansen, T
dc.creator.authorIngason, A
dc.creator.authorPirinen, M
dc.creator.authorStrengman, E
dc.creator.authorHougaard, DM
dc.creator.authorOrntoft, T
dc.creator.authorDidriksen, M
dc.creator.authorHollegaard, MV
dc.creator.authorNordentoft, M
dc.creator.authorAbramova, L
dc.creator.authorKaleda, V
dc.creator.authorArrojo, M
dc.creator.authorSanjuan, J
dc.creator.authorArango, C
dc.creator.authorEtain, B
dc.creator.authorBellivier, F
dc.creator.authorMeary, A
dc.creator.authorSchurhoff, F
dc.creator.authorSzoke, A
dc.creator.authorRibolsi, M
dc.creator.authorMagni, V
dc.creator.authorSiracusano, A
dc.creator.authorSperling, S
dc.creator.authorRossner, M
dc.creator.authorChristiansen, C
dc.creator.authorKiemeney, LA
dc.creator.authorFranke, B
dc.creator.authorvan den Berg, LH
dc.creator.authorVeldink, J
dc.creator.authorCurran, S
dc.creator.authorBolton, P
dc.creator.authorPoot, M
dc.creator.authorStaal, W
dc.creator.authorRehnstrom, K
dc.creator.authorKilpinen, H
dc.creator.authorFreitag, CM
dc.creator.authorMeyer, J
dc.creator.authorMagnusson, P
dc.creator.authorSaemundsen, E
dc.creator.authorMartsenkovsky, I
dc.creator.authorBikshaieva, I
dc.creator.authorMartsenkovska, I
dc.creator.authorVashchenko, O
dc.creator.authorRaleva, M
dc.creator.authorPaketchieva, K
dc.creator.authorStefanovski, B
dc.creator.authorDurmishi, N
dc.creator.authorMilovancevic, MP
dc.creator.authorTosevski, DL
dc.creator.authorSilagadze, T
dc.creator.authorNaneishvili, N
dc.creator.authorMikeladze, N
dc.creator.authorSurguladze, S
dc.creator.authorVincent, JB
dc.creator.authorFarmer, A
dc.creator.authorMitchell, PB
dc.creator.authorWright, A
dc.creator.authorSchofield, PR
dc.creator.authorFullerton, JM
dc.creator.authorMontgomery, GW
dc.creator.authorMartin, NG
dc.creator.authorRubino, IA
dc.creator.authorvan Winkel, R
dc.creator.authorKenis, G
dc.creator.authorDe Hert, M
dc.creator.authorRethelyi, JM
dc.creator.authorBitter, I
dc.creator.authorTerenius, L
dc.creator.authorJonsson, EG
dc.creator.authorBakker, S
dc.creator.authorvan Os, J
dc.creator.authorJablensky, A
dc.creator.authorLeboyer, M
dc.creator.authorBramon, E
dc.creator.authorPowell, J
dc.creator.authorMurray, R
dc.creator.authorCorvin, A
dc.creator.authorGill, M
dc.creator.authorMorris, D
dc.creator.authorO'Neill, FA
dc.creator.authorKendler, K
dc.creator.authorRiley, B
dc.creator.authorCraddock, N
dc.creator.authorOwen, MJ
dc.creator.authorO'Donovan, MC
dc.creator.authorThorsteinsdottir, U
dc.creator.authorKong, A
dc.creator.authorEhrenreich, H
dc.creator.authorCarracedo, A
dc.creator.authorGolimbet, V
dc.creator.authorAndreassen, Ole Andreas
dc.creator.authorBorglum, AD
dc.creator.authorMors, O
dc.creator.authorMortensen, PB
dc.creator.authorWerge, T
dc.creator.authorOphoff, RA
dc.creator.authorNothen, MM
dc.creator.authorRietschel, M
dc.creator.authorCichon, S
dc.creator.authorRuggeri, M
dc.creator.authorTosato, S
dc.creator.authorPalotie, A
dc.creator.authorSt Clair, D
dc.creator.authorRujescu, D
dc.creator.authorCollier, DA
dc.creator.authorStefansson, H
dc.creator.authorStefánsson, Kári
cristin.unitcode185,53,2,23
cristin.unitnameK.G. Jebsen senter for psykoseforskning
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2
dc.identifier.cristin1131528
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Molecular Psychiatry&rft.volume=19&rft.spage=108&rft.date=2014
dc.identifier.jtitleMolecular Psychiatry
dc.identifier.volume19
dc.identifier.startpage108
dc.identifier.endpage114
dc.identifier.doihttp://dx.doi.org/10.1038/mp.2012.157
dc.identifier.urnURN:NBN:no-47935
dc.type.documentTidsskriftartikkel
dc.type.peerreviewedPeer reviewed
dc.source.issn1359-4184
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/43572/2/Common%2Bvariant%2Bat%2B16p11.2%2Bconferring%2Brisk%2Bof%2Bpsychosis.pdf
dc.type.versionAcceptedVersion


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