dc.date.accessioned | 2015-02-12T10:33:34Z | |
dc.date.available | 2015-02-12T10:33:34Z | |
dc.date.created | 2014-12-04T11:29:35Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Madar, Ahmed Ali Knutsen, Kirsten Irene Valebjørg Stene, Lars Christian Brekke, Mette Meyer, Haakon E Lagerløv, Per . Effect of vitamin D3 supplementation on glycated hemoglobin (HbA1c), fructosamine, serum lipids, and body mass index: a randomized, doubleblinded, placebo-controlled trial among healthy immigrants living in Norway. BMJ Open Diabetes Research & Care. 2014, 2 | |
dc.identifier.uri | http://hdl.handle.net/10852/42222 | |
dc.description.abstract | Objective Despite the suggested role of vitamin D in the prevention of diabetes and cardiovascular disease or its risk factors, the evidence is not consistent and there is a paucity of randomized controlled trials in this field. We aimed to investigate the effect of 16-week daily vitamin D3 supplementation on glycated hemoglobin (HbA1c), fructosamine, body mass index (BMI), and serum lipids. Design Double-blind, randomized, placebo-controlled trial. Setting Immigrant community centers in Oslo, Norway. Participants 251 healthy adults aged 18–50 years with a non-Western immigrant background. All participants performed the baseline test and 215 (86%) returned to the follow-up test. Intervention 16 weeks of daily oral supplementation with either 10 µg vitamin D3, 25 µg vitamin D3, or placebo. Main outcome measures Difference in absolute change during the 16-week intervention between the intervention groups combined (10 or 25 µg of vitamin D3/day) and placebo, in HbA1c, fructosamine, serum lipids (total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides), and BMI. Results A total of 215 (86%) participants completed the study. Serum 25-hydroxyvitamin D increased from 29 nmol/L at baseline to 49 nmol/L after intervention, with little change in the placebo group. However, there was no difference in change of HbA1c between those receiving vitamin D3 compared with placebo (mean difference: 0.01% (95% CI -0.04 to 0.06, p=0.7)). Neither did the vitamin D3 supplementation have any effect on the other end points: fructosamine, serum lipids, and BMI. Conclusions 16-week vitamin D3 supplementation to healthy immigrants from South Asia, the Middle East, or Africa and now living in Norway with low vitamin D status did not improve HbA1c, fructosamine, lipid profiles, or BMI. An updated meta-analysis of similar published trials showed that our results were generally consistent with those of other studies. | en_US |
dc.language | EN | |
dc.language.iso | en | en_US |
dc.publisher | BMJ Publishing Group Ltd | |
dc.rights | Attribution-NonCommercial 3.0 Unported | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/ | |
dc.title | Effect of vitamin D3 supplementation on glycated hemoglobin (HbA1c), fructosamine, serum lipids, and body mass index: a randomized, doubleblinded, placebo-controlled trial among healthy immigrants living in Norway | en_US |
dc.type | Journal article | en_US |
dc.creator.author | Madar, Ahmed Ali | |
dc.creator.author | Knutsen, Kirsten Irene Valebjørg | |
dc.creator.author | Stene, Lars Christian | |
dc.creator.author | Brekke, Mette | |
dc.creator.author | Meyer, Haakon E | |
dc.creator.author | Lagerløv, Per | |
cristin.unitcode | 185,52,14,0 | |
cristin.unitname | Avdeling for samfunnsmedisin | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1180818 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=BMJ Open Diabetes Research & Care&rft.volume=2&rft.spage=&rft.date=2014 | |
dc.identifier.jtitle | BMJ Open Diabetes Research & Care | |
dc.identifier.volume | 2 | |
dc.identifier.pagecount | 8 | |
dc.identifier.doi | http://dx.doi.org/10.1136/bmjdrc-2014-000026 | |
dc.identifier.urn | URN:NBN:no-46603 | |
dc.subject.nvi | VDP::Samfunnsmedisin, sosialmedisin: 801 | |
dc.type.document | Tidsskriftartikkel | en_US |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2052-4897 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/42222/1/Madar_2014_Eff.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | e000026 | |