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(Doctoral thesis / Doktoravhandling, 2012)
(Doctoral thesis / Doktoravhandling, 2012)
Zopiclone is one of the most commonly prescribed sleep medications in the world. Driving in the morning, after regular nighttime zopiclone consumption, is, by many, considered to be safe traffic wise, due to the fast ...
(Doctoral thesis / Doktoravhandling, 2010)
Elektiv ortopedisk kirurgi hos pasienter med revmatisk leddsykdom
Revmatiske sykdommer fører ofte til leddsmerter og redusert fysisk funksjon. I denne studien rapporterte en stor gruppe pasienter med leddgikt en generell ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2013)
Background: Cognitive Remediation Therapy (CRT) aims at improving neuropsychological weaknesses and associated thinking styles in patients with anorexia nervosa (AN). It has only recently been developed for adolescents ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Background
Rett syndrome (RTT) is a neurodevelopmental disorder. In more than 95% of females with classic RTT a pathogenic mutation in MECP2 has been identified. This leaves a small fraction of classic cases ...
(Doctoral thesis / Doktoravhandling, 2022)
Hypertensive disorders of pregnancy include preeclampsia and gestational hypertension. Preeclampsia is a leading cause of maternal mortality, stillbirth and preterm delivery, and has potential long-term health consequences ...
(Doctoral thesis / Doktoravhandling, 2018)
Children born to substance-dependent mothers who themselves have had an upbringing disturbed by parental substance-abuse, are at high risk. The mothers in this study represent a vulnerable group, difficult for researchers ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2015)
Inflammation is central to heart failure progression. Innate immune signaling increases expression of the transmembrane proteoglycan syndecan-4 in cardiac myocytes and fibroblasts, followed by shedding of its ectodomain. ...
(Doctoral thesis / Doktoravhandling, 2018)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2024)
Background
Decisions regarding maintenance therapy in patients with multiple myeloma should be based on both treatment efficacy and health-related quality of life (HRQL) consequences. In the CARFI trial, ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Background
Impairments in social cognition are common after traumatic brain injury (TBI) and may have severe negative consequences for patients and their families. Most tests of social cognition have limited ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Background
The chromosomal translocation t(11;19)(q23;p13) with a breakpoint within subband 19p13.1 is found mainly in acute myeloid leukemia (AML) and results in the MLL-ELL fusion gene. Variations in the ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
Objectives Recurrent headache co-occurs commonly with psychological distress, such as anxiety or depression. Potentially traumatic interpersonal events (PTIEs) could represent important precursors of psychological distress ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Purpose Eye and hand motor dysfunction may be present early in the disease course of relapsing-remitting multiple sclerosis (RRMS), and can affect the results on visual and written cognitive tests. We aimed to test for ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background
Epidemiological studies have shown that long-term exposure to paracetamol during pregnancy is associated with attention-deficit/hyperactivity disorder (ADHD). The mechanism by which paracetamol ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2014)
Aims:Overweight and obesity in children and adolescents are major public health challenges associated with psychosocial adversity and unfavourable lifestyle. Exposure to interpersonal violence, such as sexual abuse, violence ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Background
Recent research suggests that a basic anomaly in self-experience may be a core factor in patients with severe mental illnesses. Given the importance of sense of self, the traditional treatment ...
(Doctoral thesis / Doktoravhandling, 2014)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Background
Obesity during adolescence is associated with cardiovascular mortality in adulthood. The adverse obesity-related cardiometabolic risk profile is already observed in adolescence. We aimed to examine ...
(Doctoral thesis / Doktoravhandling, 2016)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
A population-based study was performed to investigate the efficacy of mecillinam treatment of community-acquired urinary tract infections (CA-UTI) caused by extended-spectrum ß-lactamase (ESBL) producing Escherichia coli. ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Background
Understanding the determinants associated with prediabetes and type 2 diabetes in coronary patients may help to individualize treatment and modelling interventions. We sought to identify ...
(Doctoral thesis / Doktoravhandling, 2014)
Background
A hip fracture is a dramatic event with serious consequences. Many patients do not survive the first year after the fracture, and those who survive will often experience loss of function and increased need of ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
VTI1A-TCF7L2 was reported as a recurrent fusion gene in colorectal cancer (CRC), found to be expressed in three out of 97 primary cancers, and one cell line, NCI-H508, where a genomic deletion joins the two genes [1]. To ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Background
Substance use disorders (SUDs) constitute a major health problem and are associated with an extensive psychiatric comorbidity. Personality disorders (PDs) and SUDs commonly co-occur. Comorbid ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Background
Mental disorders often have onset early in life, contribute substantially to the global disease burden, and may interfere with young people’s ability to complete age-relevant tasks in important ...
(Doctoral thesis / Doktoravhandling, 2017)
(Doctoral thesis / Doktoravhandling, 2017)
Providing family caregivers with information, support and respite is an important fundamental objective of dementia care. Day care is one of several support and respite services for family caregivers, but there was a need ...
(Doctoral thesis / Doktoravhandling, 2013)
Dual Antiplatelet therapy with aspirin and clopidogrel is a cornerstone in treatment of patients with acute coronary syndromes (ACS) and after percutaneous coronary intervention (PCI), and aspirin is established as ...
(Doctoral thesis / Doktoravhandling, 2017)
Patients and General Practitioners (GPs) agree that municipal acute wards represent good services for the patients. Patients experience the service as safe, receiving treatment and care from competent nurses and doctors ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background
Excessive daytime sleepiness (EDS, defined as Epworth sleepiness scale score > 10) is a common symptom, with a prevalence of 10–20% in the general population. It is associated with headache and ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Background
Personalized therapy considering clinical and genetic patient characteristics will further improve breast cancer survival. Two widely used treatments, chemotherapy and radiotherapy, can induce ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Background
The endovascular treatment procedure in tandem occlusions (TO) is complex compared to single occlusion (SO) and optimal management remains uncertain. The aim of this study was to identify clinical ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Background
Therapeutic hypothermia has become the standard of care for newborns with hypoxic-ischemic encephalopathy in high and middle income countries. Docosahexaenoic acid (DHA) has neuroprotective properties of ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Background
The EQ-5D-3 L instrument is a standardized questionnaire which was developed as a simple, generic measure of health for clinical and economic appraisal. To aid in the interpretation, scores are ...
GFRA3 promoter methylation may be associated with decreased postoperative survival in gastric cancer
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Background
A large number of epigenetic alterations has been found to be implicated in the etiology of gastric cancer. We have studied the DNA methylation status of 27 500 gene promoter regions in 24 gastric ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2022)
Functional precision medicine is a new, emerging area that can guide cancer treatment by capturing information from direct perturbations of tumor-derived, living cells, such as by drug sensitivity screening. Precision ...
(Doctoral thesis / Doktoravhandling, 2020)
Zopiclone is a frequently prescribed hypnotic drug. Related to the therapeutic effects is impairment of cognitive functioning and psychomotor skills. The thesis is based on a double blind, placebo-controlled, crossover, ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Background: Reliable identification of Mycobacterium tuberculosis infection or tuberculosis (TB) disease in young children is vital to assure adequate preventive and curative treatment. The tuberculin skin test (TST) and ...
(Doctoral thesis / Doktoravhandling, 2013)
The therapeutic relationship is one factor that makes consistent contribution to outcome independent of type of therapy. The emotional exchange between persons is a vital part of any relationship, and psychotherapists’ ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Background
Multi-item rating scales for depression informs about the level of depression, but does not allow individuals to state by self-evaluation whether they feel depressed or not. The insider perspective ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background
With an increasing number of people with dementia worldwide and limited advancement in medical treatments, the call for new and cost-effective approaches is crucial. The utility of self-management ...
(Doctoral thesis / Doktoravhandling, 2022)
Worldwide today, 38 million people live with HIV and in 2020 700.000 died of HIV related disease. HIV infects CD4 T cells and causes a gradual decline in these cells. Antiretroviral treatment (ART) will in most people ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
Background Immigrants from South Asia to Western countries have a high prevalence of type 2 diabetes mellitus (T2DM). We explored pathogenic factors that might contribute to the high risk of T2DM in Pakistani immigrants ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2015)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Introduction
Pain management can be challenging, especially in remote locations where first responders are not certified health care personnel. In these settings, traditional intravenous administration of ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Background
Most studies of services for people with severe mental illness have been performed in cities. Our 7-year follow-up study aimed to investigate clinical course and satisfaction with services among ...
(Doctoral thesis / Doktoravhandling, 2013)
Objective: The aim of this thesis is to examine sleep problems in a clinical sample of children with anxiety and attention deficit/hyperactivity disorder (ADHD). The more specific aims are to investigate the frequency, the ...
(Doctoral thesis / Doktoravhandling, 2011)
Background<br>
The principles of good communication between doctors and patients are well known. We also know that learner centred training improves doctors’ communication skills. Most studies have, however, been done ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Background
People with severe mental illness have markedly reduced life expectancy; cardiometabolic disease is a major cause. Psychiatric hospital inpatients have elevated levels of cardiometabolic risk ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background
The transition period between child and adolescent mental health services (CAMHS) and adult mental health services (AMHS) has been identified as an especially critical time for patients with anorexia nervosa. ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Background: Cesarean delivery is performed under spinal anesthesia, and vasodilation is the main cause for a drop in blood pressure. The compression of the aorta and inferior vena cava by the gravid uterus is of additional ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background
Adolescent depression is a common mental health problem and there is an urgent need for effective and accessible treatments. Internet-based interventions solve many obstacles for seeking and receiving treatment, ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2014)
Background: Quality of life (QoL) is a well-established outcome within clinical practice. Despite the adverse effects of substance use disorders on a wide range of patients’ functionality and the multidimensional composition ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Over the last decade, the brain's default-mode network (DMN) and its function has attracted a lot of attention in the field of neuroscience. However, the exact underlying mechanisms of DMN functional connectivity, or more ...
(Doctoral thesis / Doktoravhandling, 2009)
Sepsis is a systemic inflammatory response syndrome caused by infection. The morbidity and mortality in sepsis is high despite of modern treatment with broad-spectrum antibiotics and supportive therapy. This fact reflects ...
(Doctoral thesis / Doktoravhandling, 2019)
Hemolytic-uremic syndrome (HUS) is a severe clinical syndrome defined by impaired renal function, hemolytic anemia and thrombocytopenia. It mainly affects children of pre-school age, and is one of the most common causes ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Background Vacc-4x, a Gag p24-based therapeutic HIV vaccine, has been shown to reduce viral load set-points after intradermal administration. In this randomized controlled pilot study we investigate intranasal administration ...
(Doctoral thesis / Doktoravhandling, 2016)
Opp til 30 % av hjerneslag er forårsaket av blodpropp fra åreforkalkning (plakk) i halspulsåren. Denne typen hjerneinfarkt kan forhindres ved kirurgisk fjerning av plakket. Utvelgelse av pasienter til denne typen kirurgi ...
(Doctoral thesis / Doktoravhandling, 2016)
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
Objective: In Norway, diagnoses from specialist health care visits, drug prescriptions, and causes of deaths are registered in compulsory health registers. We aimed to determine amyotrophic lateral sclerosis (ALS) prevalence ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Background Following the demonstration that histone deacetylase inhibitors enhanced experimental radiation-induced clonogenic suppression, the Pelvic Radiation and Vorinostat (PRAVO) phase 1 study, combining fractionated ...
(Doctoral thesis / Doktoravhandling, 2013)
Introduksjon: Få studier har undersøkt pasienter og personalets opplevelse av behandlingsmiljøet på psykiatriske institusjoner ut fra et læringsperspektiv. Hensikten med denne studien var å få mer kunnskap om hvilken mening ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Background Insomnia and depression are strongly interrelated. This study aimed to describe changes in sleep across childbirth, and to evaluate whether insomnia in pregnancy is a predictor of postpartum depression. Methods ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background
Patients with type 1 diabetes (T1D) are at increased risk of cardiovascular disease (CVD). Measures of high-density lipoprotein (HDL) function provide a better risk estimate for future CVD events ...
(Doctoral thesis / Doktoravhandling, 2011)
Encapsulating cytostatics into lipid vesicles, i.e. liposomes, improves tumour drug accumulation and reduce adverse effects. Liposomal doxorubicin (DXR) has been used in the treatment of a variety of cancers and may also ...
(Doctoral thesis / Doktoravhandling, 2011)
Brain structural abnormalities as well as neurocognitive dysfunction, are found in schizophrenia and in bipolar disorder. Based on the fact that both brain structure and neurocognitive functioning are significantly heritable ...
(Doctoral thesis / Doktoravhandling, 2011)
Thousands of DNA lesions, in form of chemical modifications, base loss and single-strand breaks are estimated to occur in every cell per day. Excision repair pathways and cell cycle checkpoints have evolved as part of the ...
(Doctoral thesis / Doktoravhandling, 2008)
Modern reperfusion strategies and medical treatment reduce myocardial necrosis and have improved prognosis after acute myocardial infarction. However, some patients still develop extensive myocardial infarctions and are ...
(Doctoral thesis / Doktoravhandling, 2010)
Ventricular function after operation for transposition of the great arteries with special reference to myocardial deformation
Transposition of the great arteries (TGA) is the second most common cyanotic congenital heart ...
(Doctoral thesis / Doktoravhandling, 2010)
(Doctoral thesis / Doktoravhandling, 2011)
(Doctoral thesis / Doktoravhandling, 2011)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Background: The prevalence of infections caused by Cefotaximase-Munich (CTX-M)-type extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) has rapidly increased during the past 15 years. Enterobacteriaceae ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Background
Successful treatment of latent tuberculosis infection (LTBI) is essential to reduce tuberculosis (TB) incidence rates in low-burden countries. This study measures treatment completion and ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Introduction: Myocardial dysfunction is common after out-of-hospital cardiac arrest (OHCA) and high-sensitivity troponin T (hs-TnT) levels may provide incremental prognostic information to established risk indices.
Methods: ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Background: Schizophrenia is among the major causes of disability worldwide and the mortality from cardiovascular disease (CVD) is significantly elevated. There is a growing concern that this health challenge is not fully ...
(Doctoral thesis / Doktoravhandling, 2016)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Background: While Web-based interventions have been shown to assist a wide range of patients successfully in managing their illness, few studies have examined the relative contribution of different Web-based components to ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Type 1 diabetes and celiac disease result from misdirected immune mediated destruction of host cells, and are among the most common chronic diseases in children. Despite changes in incidence over the past 3 decades, little ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Background Osteoarthritis (OA) of the knee is a common and disabling condition. We wanted to investigate the modifiable risk factors Body Mass Index (BMI) and physical activity, using knee replacement (KR) as a marker for ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
Background: Neonates from low and middle income countries (LAMIC) tend to have lower birth weight compared with Western European (WE) neonates. Parental height, BMI and maternal parity, age and educational level often ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Idiopathic spinal cord herniation (ISCH), where a segment of the spinal cord has herniated through a ventral defect in the dura, is a rarely encountered cause of thoracic myelopathy. The purpose of our study was to increase ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Background
Ductal carcinoma in situ (DCIS) is a non-invasive form of breast cancer. It is often associated with invasive ductal carcinoma (IDC), and is considered to be a non-obligate precursor of IDC. It ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Key Clinical Message
X-linked adrenoleukodystrophy may present with a deceptively mild phenotype, even in adult males. Tight collaboration between clinicians, geneticists, biochemists, and other specialists is increasingly ...
(Doctoral thesis / Doktoravhandling, 2013)
Background<br>
The Norwegian Health Care system significantly differs from international settings such as the U.S., where the majority of research on pregnant opioid dependent women is conducted. Hence results from ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
The study of chromatin 3D structure has recently gained much focus owing to novel techniques for detecting genome-wide chromatin contacts using next-generation sequencing. A deeper understanding of the architecture of the ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
Background The objectives of this study were; (1) to assess the prevalence and frequency of headache in patients referred to polysomnography (PSG) due to a clinical suspicion of obstructive sleep apnea (OSA) or another ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Background: Gene variants known to contribute to Autoimmune Addison’s disease (AAD) susceptibility include those at the MHC, MICA, CIITA, CTLA4, PTPN22, CYP27B1, NLRP-1 and CD274 loci. The majority of the genetic component ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Intratumor heterogeneity caused by genetic, phenotypic or functional differences between cancer cell subpopulations is a considerable clinical challenge. Understanding subpopulation dynamics is therefore central for both ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Background: Several environmental exposures, including infection with Epstein-Barr virus, low levels of vitamin D and smoking are established risk factors for multiple sclerosis (MS). Also, high hygienic standard and ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
We explored the association between preeclampsia and later use of antihypertensive drugs in a population-based study with data from the Medical Birth Registry of Norway and the Norwegian Prescription Database. The study ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
The cholesterol-lowering drug atorvastatin is among the most prescribed drug in the world. Alternative splicing in a number of genes has been reported to be associated with variable statin response. RNA-seq has proven to ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
Background Few studies have focused on fatigue in myasthenia gravis (MG), and fatigue in relation to the autonomic system has never been systematically explored in these patients. The study aimed to document the prevalence ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background
For an individual participant data (IPD) meta-analysis, multiple datasets must be transformed in a consistent format, e.g. using uniform variable names. When large numbers of datasets have to be ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
To review the most important moral challenges following from the widespread use of bariatric surgery for type 2 diabetes for patients with BMI < 35 kg/m2, although high quality evidence for its short and long term effectiveness ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background
Attention deficit/hyperactivity disorder (ADHD) entails inattention, impulsivity, and restlessness at a disabling level. The pharmacological treatment of ADHD rests on the use of centrally acting ...
(Doctoral thesis / Doktoravhandling, 2015)
Background: Opioid dependence is linked to crime, morbidity and mortality, directly through drug overdoses and indirectly via drug-related mortality, accidents, suicides and violence. Violence in general is a major health ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Background: Hemodynamic control was compared in patients with mild cognitive impairment (MCI) or mild Alzheimer's dementia (AD) as well as in healthy elderly subjects. Methods: Noninvasive, continuous hemodynamic recordings ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background
Epigenetic information can be used to identify clinically relevant genomic variants single nucleotide polymorphisms (SNPs) of functional importance in cancer development. Super-enhancers are ...