Browsing Institutt for helse og samfunn by Author "Lyle, Robert"

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  • An EPIC predictor of gestational age and its application to newborns conceived by assisted reproductive technologies 
    Haftorn, Kristine L; Lee, Yunsung; Denault, William R P; Page, Christian M; Nustad, Haakon E; Lyle, Robert; Gjessing, Håkon K; Malmberg, Anni; Magnus, Maria C; Næss, Øyvind; Czamara, Darina; Räikkönen, Katri; Lahti, Jari; Magnus, Per; Håberg, Siri E; Jugessur, Astanand; Bohlin, Jon (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Background Gestational age is a useful proxy for assessing developmental maturity, but correct estimation of gestational age is difficult using clinical measures. DNA methylation at birth has proven to be ...
  • Blood-based epigenetic estimators of chronological age in human adults using DNA methylation data from the Illumina MethylationEPIC array 
    Lee, Yunsung; Haftorn, Kristine L; Denault, William R P; Nustad, Haakon E; Page, Christian M; Lyle, Robert; Lee-Ødegård, Sindre; Moen, Gunn-Helen; Prasad, Rashmi B; Groop, Leif C; Sletner, Line; Sommer, Christine; Magnus, Maria C; Gjessing, Håkon K; Harris, Jennifer R; Magnus, Per; Håberg, Siri E; Jugessur, Astanand; Bohlin, Jon (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Background Epigenetic clocks have been recognized for their precise prediction of chronological age, age-related diseases, and all-cause mortality. Existing epigenetic clocks are based on CpGs from the ...
  • Nucleated red blood cells explain most of the association between DNA methylation and gestational age 
    Haftorn, Kristine Løkås; Denault, William Robert Paul; Lee, Yunsung; Page, Christian Magnus; Romanowska, Julia; Lyle, Robert; Næss, Øyvind Erik; Kristjansson, Dana; Magnus, Per Minor; Håberg, Siri Eldevik; Bohlin, Jon; Jugessur, Astanand (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Determining if specific cell type(s) are responsible for an association between DNA methylation (DNAm) and a given phenotype is important for understanding the biological mechanisms underlying the association. Our EWAS of ...
  • The CRCbiome study: a large prospective cohort study examining the role of lifestyle and the gut microbiome in colorectal cancer screening participants 
    Kværner, Ane S.; Birkeland, Einar; Bucher-Johannessen, Cecilie; Vinberg, Elina; Nordby, Jan I.; Kangas, Harri; Bemanian, Vahid; Ellonen, Pekka; Botteri, Edoardo; Natvig, Erik; Rognes, Torbjørn; Hovig, Eivind; Lyle, Robert; Ambur, Ole H.; de Vos, Willem M.; Bultman, Scott; Hjartåker, Anette; Landberg, Rikard; Song, Mingyang; Blix, Hege S.; Ursin, Giske; Randel, Kristin R.; de Lange, Thomas; Hoff, Geir; Holme, Øyvind; Berstad, Paula; Rounge, Trine B. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Background Colorectal cancer (CRC) screening reduces CRC incidence and mortality. However, current screening methods are either hampered by invasiveness or suboptimal performance, limiting their effectiveness ...