Browsing Institutt for helse og samfunn by Author "Eldholm, Vegard"

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  • Acquisition of virulence genes by a carrier strain gave rise to the ongoing epidemics of meningococcal disease in West Africa 
    Brynhildsrud, Ola Brønstad; Eldholm, Vegard; Bohlin, Jon; Uadiale, Kennedy; Obaro, Stephen; Caugant, Dominique A (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    In the African meningitis belt, a region of sub-Saharan Africa comprising 22 countries from Senegal in the west to Ethiopia in the east, large epidemics of serogroup A meningococcal meningitis have occurred periodically. ...
  • Gauging the epidemic potential of a widely circulating non-invasive meningococcal strain in Africa 
    Brynildsrud, Ola Brønstad; Eldholm, Vegard; Rakhimova, Adilya; Kristiansen, Paul Arne; Caugant, Dominique A (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Neisseria meningitidis colonizes the human oropharynx and transmits mainly via asymptomatic carriage. Actual outbreaks of meningococcal meningitis are comparatively rare and occur when susceptible populations are exposed ...
  • Genomic epidemiology and population structure of Neisseria gonorrhoeae in Norway, 2016–2017 
    Alfsnes, Kristian; Eldholm, Vegard; Olsen, Anne Olaug; Brynildsrud, Ola Brønstad; Bohlin, Jon; Steinbakk, Martin; Caugant, Dominique A (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    This study presents the nationwide epidemiology of Neisseria gonorrhoeae , using whole-genome sequencing of all culture-positive cases, which comprise roughly 40 % of all cases of gonorrhea reported in Norway from 2016 to ...
  • Naturally occurring Neisseria gonorrhoeae can have large deletions in housekeeping gene abcZ, making them untypable with multilocus sequence typing 
    Vollan, Hilde Synnøve; Caugant, Dominique Andree Yvette; Eldholm, Vegard; Alfsnes, Kristian; Debech, Nadia; Brynildsrud, Ola Brønstad (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    The abcZ gene is an essential housekeeping gene in all the Neisseria species. It is one of the seven genes used for multilocus sequence typing (MLST) this genus. It encodes the cytosolic component of an ATP-binding cassette ...
  • Sudden emergence of a Neisseria gonorrhoeae clade with reduced susceptibility to extended-spectrum cephalosporins, Norway 
    Osnes, Magnus Nygård; Didelot, Xavier; de Korne-Elenbaas, Jolinda; Alfsnes, Kristian; Brynildsrud, Ola Brønstad; Syversen, Gaute; Nilsen, Øivind Jul; de Blasio, Birgitte Freiesleben; Caugant, Dominique A; Eldholm, Vegard (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Neisseria gonorrhoeae multilocus sequence type (ST)-7827 emerged in a dramatic fashion in Norway in the period 2016–2018. Here, we aim to shed light on the provenance and expansion of this ST. ST-7827 was found to be ...
  • The effect of recombination on the evolution of a population of Neisseria meningitidis 
    MacAlasdair, Neil; Pesonen, Maiju; Brynildsrud, Ola Brønstad; Eldholm, Vegard; Kristiansen, Paul Arne; Corander, Jukka; Caugant, Dominique Andree Yvette; Bentley, Stephen D. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Neisseria meningitidis (the meningococcus) is a major human pathogen with a history of high invasive disease burden, particularly in sub-Saharan Africa. Our current understanding of the evolution of meningococcal genomes ...
  • The impact of global lineage dynamics, border restrictions, and emergence of the B.1.1.7 lineage on the SARS-CoV-2 epidemic in Norway 
    Osnes, Magnus Nygård; Alfsnes, Kristian; Bråte, Jon; Garcia Llorente, Ignacio; Riis, Rasmus Kopperud; Instefjord, Kamilla Heddeland; Elshaug, Hilde; Vollan, Hilde Synnøve; Moen, Line Victoria; Pedersen, Benedikte Nevjen; Caugant, Dominique Andree Yvette; Stene-Johansen, Kathrine; Hungnes, Olav; Bragstad, Karoline; Brynildsrud, Ola Brønstad; Eldholm, Vegard (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Abstract As the COVID-19 pandemic swept through an immunologically naïve human population, academics and public health professionals scrambled to establish methods and platforms for genomic surveillance and data ...