Browsing Institutt for helse og samfunn by Author "Caugant, Dominique A"

Now showing items 1-15 of 15

  • Acquisition of virulence genes by a carrier strain gave rise to the ongoing epidemics of meningococcal disease in West Africa 
    Brynhildsrud, Ola Brønstad; Eldholm, Vegard; Bohlin, Jon; Uadiale, Kennedy; Obaro, Stephen; Caugant, Dominique A (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    In the African meningitis belt, a region of sub-Saharan Africa comprising 22 countries from Senegal in the west to Ethiopia in the east, large epidemics of serogroup A meningococcal meningitis have occurred periodically. ...
  • Cost-effectiveness of meningococcal vaccination of Norwegian teenagers with a quadrivalent ACWY conjugate vaccine 
    Watle, Sara Sofie Viksmoen; Næss, Lisbeth Meyer; Tunheim, Gro; Caugant, Dominique A; Wisløff, Torbjørn (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    n Norway, the incidence of invasive meningococcal disease (IMD) is higher among 16–19-year-olds than in the general population. Most IMD cases among teenagers are caused by serogroup Y. Since 2011, one dose of meningococcal ...
  • Gauging the epidemic potential of a widely circulating non-invasive meningococcal strain in Africa 
    Brynildsrud, Ola Brønstad; Eldholm, Vegard; Rakhimova, Adilya; Kristiansen, Paul Arne; Caugant, Dominique A (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Neisseria meningitidis colonizes the human oropharynx and transmits mainly via asymptomatic carriage. Actual outbreaks of meningococcal meningitis are comparatively rare and occur when susceptible populations are exposed ...
  • Genomic epidemiology and population structure of Neisseria gonorrhoeae in Norway, 2016–2017 
    Alfsnes, Kristian; Eldholm, Vegard; Olsen, Anne Olaug; Brynildsrud, Ola Brønstad; Bohlin, Jon; Steinbakk, Martin; Caugant, Dominique A (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    This study presents the nationwide epidemiology of Neisseria gonorrhoeae , using whole-genome sequencing of all culture-positive cases, which comprise roughly 40 % of all cases of gonorrhea reported in Norway from 2016 to ...
  • Meningococcal carriage in Norwegian teenagers: strain characterisation and assessment of risk factors 
    Watle, Sara Sofie Viksmoen; Caugant, Dominique A; Tunheim, Gro; Bekkevold, Terese; Laake, Ida; Brynildsrud, Ola Brønstad; Næss, Lisbeth Meyer (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Abstract Teenagers have a higher risk of invasive meningococcal disease (IMD) than the general population. This cross-sectional study aimed to characterise strains of Neisseria meningitidis circulating among Norwegian ...
  • Molecular studies of meningococcal and pneumococcal meningitis patients in Ethiopia 
    Mihret, Wude; Brusletto, Berit Sletbakk; Øvstebø, Reidun; Siebke, Anne-Marie; Norheim, Gunnstein; Merid, Yared; Kassu, Afework; Abebe, Workeabeba; Ayele, Samuel; Silamsaw, Mezgebu; Yamuah, Lawrence; Aseffa, Abraham; Petros, Beyene; Caugant, Dominique A; Brandtzaeg, Petter (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Neisseria meningitidis infections in sub-Saharan Africa usually present with distinct symptoms of meningitis but very rarely as fulminant septicemia when reaching hospitals. In Europe, development of persistent meningococcal ...
  • New molecular tools for meningitis diagnostics in Ethiopia – a necessary step towards improving antimicrobial prescription 
    Bårnes, Guro K; Gudina, Esayas K; Berhane, Melkamu; Abdissa, Alemseged; Tesfaw, Getnet; Abebe, Gemeda; Feruglio, Siri L; Caugant, Dominique A; Jørgensen, Hannah J (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Background Meningitis remains a top cause of premature death and loss of disability-adjusted life years in low-income countries. In resource-limited settings, proper laboratory diagnostics are often scarce ...
  • Next generation rapid diagnostic tests for meningitis diagnosis 
    Feagins, Alicia R.; Ronveaux, Olivier; Taha, Muhamed-Kheir; Caugant, Dominique A; Smith, Vinny; Fernandez, Katya; Glennie, Linda; Fox, LeAnne M.; Wang, Xin (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
    Rapid diagnostic tests (RDTs) are increasingly recognized as valuable, transformative tools for the diagnosis of infectious diseases. Although there are a variety of meningitis RDTs currently available, certain product ...
  • Outer membrane phospholipase A’s roles in Helicobacter pylori acid adaptation 
    Vollan, Hilde S; Tannæs, Tone; Caugant, Dominique A; Vriend, Gert; Bukholm, Geir (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Background The pH of the human gastric mucosa varies around 2.5 so that only bacteria with strong acidic stress tolerance can colonize it. The ulcer causing Helicobacter pylori thrives in the gastric mucosa. ...
  • Persistent low carriage of serogroup A Neisseria meningitidis two years after mass vaccination with the meningococcal conjugate vaccine, MenAfriVac 
    Kristiansen, Paul Arne; Ba, Absatou Ky; Ouédraogo, Abdoul-Salam; Sanou, Idrissa; Ouédraogo, Rasmata; Sangaré, Lassana; Diomandé, Fabien; Kandolo, Denis; Saga, Inger Marie; Misegades, Lara; Clark, Thomas A.; Préziosi, Marie-Pierre; Caugant, Dominique A (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
    Background The conjugate vaccine against serogroup A Neisseria meningitidis (NmA), MenAfriVac, is currently being introduced throughout the African meningitis belt. In repeated multicentre cross-sectional studies in Burkina ...
  • Phylogenetic relationships and regional spread of meningococcal strains in the meningitis belt, 2011–2016 
    Topaz, Nadav; Caugant, Dominique A; Taha, Muhamed-Kheir; Brynildsrud, Ola Brønstad; Debech, Nadia; Hong, Eva; Deghmane, Ala-Eddine; Ouédraogo, Rasmata; Ousmane, Sani; Gamougame, Kadidja; Njanpop-Lafourcade, Berthe-Marie; Diarra, Seydou; Fox, Leanne M.; Wang, Xin (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Background Historically, the major cause of meningococcal epidemics in the meningitis belt of sub-Saharan Africa has been Neisseria meningitidis serogroup A (NmA), but the incidence has been substantially reduced since ...
  • Salivary and serum antibody response against Neisseria meningitidis after vaccination with conjugate polysaccharide vaccines in Ethiopian volunteers 
    Bårnes, Guro Kristine; Workalemahu, Bereket; Kristiansen, Paul Arne; Beyene, Demissew Balcha; Merdekios, Behailu; Fissiha, P.; Aseffa, Abraham; Caugant, Dominique A; Næss, Lisbeth Meyer (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
    Meningococcal conjugate vaccines induce serum antibodies crucial for protection against invasive disease. Salivary antibodies are believed to be important for hindering meningococcal acquisition and/or clearance of established ...
  • Sudden emergence of a Neisseria gonorrhoeae clade with reduced susceptibility to extended-spectrum cephalosporins, Norway 
    Osnes, Magnus Nygård; Didelot, Xavier; de Korne-Elenbaas, Jolinda; Alfsnes, Kristian; Brynildsrud, Ola Brønstad; Syversen, Gaute; Nilsen, Øivind Jul; de Blasio, Birgitte Freiesleben; Caugant, Dominique A; Eldholm, Vegard (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Neisseria gonorrhoeae multilocus sequence type (ST)-7827 emerged in a dramatic fashion in Norway in the period 2016–2018. Here, we aim to shed light on the provenance and expansion of this ST. ST-7827 was found to be ...
  • Surveillance of bacterial meningitis, Ethiopia, 2012–2013 
    Mihret, Wude; Lema, Tsehaynesh; Merid, Yared; Kassu, Afework; Abebe, Workeabeba; Moges, Beyene; Tenna, Admasu; Woldegebriel, Fitsum; Yidnekachew, Melaku; Mekonnen, Wondale; Yamuah, Lawrence; Ahmed, Arslan; Silamsaw, Mezgebu; Petros, Beyene; Oksnes, Jan; Rosenqvist, Einar; Ayele, Samuel; Caugant, Dominique A; Aseffa, Abraham; Norheim, Gunnstein (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
    Ethiopia has the second-largest population (≈94 million in 2013) among the meningitis belt countries of sub-Saharan Africa (1). However, during 2001–2010, a median of only 1,056 suspected meningitis cases per year (range ...
  • Whole genome sequencing reveals within-host genetic changes in paired meningococcal carriage isolates from Ethiopia 
    Bårnes, Guro Kristine; Brynildsrud, Ola Brønstad; Børud, Bente; Workalemahu, Bereket; Kristiansen, Paul Arne; Beyene, Demissew; Aseffa, Abraham; Caugant, Dominique A (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Background: Meningococcal colonization is a prerequisite for transmission and disease, but the bacterium only very infrequently causes disease while asymptomatic carriage is common. Carriage is highly dynamic, showing a ...