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(Master thesis / Masteroppgave, 2019)
Production of autoantibodies by TG2-specific gut plasma cells is a hallmark of celiac disease. Previous studies have revealed biased selection of IGHV and IGKV gene segments, low number of mutations and preferential targeting ...
(Master thesis / Masteroppgave, 2017)
Studies of TRIM21-mediated intracellular virus neutralization Restricted Access
(Master thesis / Masteroppgave, 2015)
Cellular effects of Th-227 Restricted Access
(Master thesis / Masteroppgave, 2014)
CD4+ TH-cell epitope discovery by combinatorial phage display of MHC class II A proof of principle study Restricted Access
(Master thesis / Masteroppgave, 2014)
The interaction between a CD4+ TH cell and an antigen presenting cell (APC) is a finely tuned event in adaptive immunity. The affinity is dictated by the T cell receptor (TCR) and the characteristics of antigenic peptide ...
(Master thesis / Masteroppgave, 2020)
The purpose of this study was to find whether exosomes can function as biomarkers for acute leukemia in children, with the long-term goal to assess whether exosomes can be used to predict risk of relapse.
Structure-function relationship of Shiga toxins; Role of the A-subunit in complex stability and endocytosis Restricted Access
(Master thesis / Masteroppgave, 2014)
Human IgG subclasses in intracellular antiviral immunity Restricted Access
(Master thesis / Masteroppgave, 2018)
An investigation of the functional role of the MADS-box γ and MADS-box α type I transcription factors: AGAMOUS-LIKE 28 and AGAMOUS-LIKE 36 Restricted Access
(Master thesis / Masteroppgave, 2014)
(Master thesis / Masteroppgave, 2019)
microRNAs (miRNAs) are short RNA molecules, which post-transcriptionally regulate other genes. They are generated from genome-encoded single-stranded hairpin structures, by a set of RNA-processing enzymes. miRNAs are highly ...
The role of Gβγ subunits in pertussis toxin amplification of β-adrenoceptor evoked activation of adenylyl cyclase Restricted Access
(Master thesis / Masteroppgave, 2015)
The inhibitory G protein (Gi) has been proposed to participate in β2-adrenergic receptor (β2AR) signaling, but not in β1-adrenergic receptor (β1AR) signaling. Pertussis toxin (PTX) ADP-ribosylates and inhibits Gi, and ...
In vitro studies of nanosized iron oxide particles Restricted Access
(Master thesis / Masteroppgave, 2013)
Iron oxide nanoparticles are widely used for magnetic resonance imaging, and there is a rapidly expanding research interest in using these nanoparticles for drug delivery or cell labeling. Therefore we need a better ...
Effects of the mycotoxin Deoxynivalenol and grain components on intestinal in vitro model systems Restricted Access
(Master thesis / Masteroppgave, 2019)
Functional Analysis of Stress Signaling in Prostate Cancer Cells Restricted Access
(Master thesis / Masteroppgave, 2016)
Immune Cell Composition in Human Non-Small Cell Lung Cancer Restricted Access
(Master thesis / Masteroppgave, 2014)
Background: Tumor-infiltrating immune cells analyzed by immunohistochemistry are reported as alternative prognostic factors to supplement TNM staging in operable non-small cell lung cancer (NSCLC), but little is done by ...
(Master thesis / Masteroppgave, 2014)
(Master thesis / Masteroppgave, 2017)
The medial entorhinal cortex (MEC) spatially modulated neurons, including grid cells, all contribute to the brain's spatial navigation system. The mechanisms behind the grid cells' hexagonal firing pattern in space remain ...
(Master thesis / Masteroppgave, 2016)
Characterization of eIF2α kinases in prostate cancer cells Restricted Access
(Master thesis / Masteroppgave, 2019)
Cancer is the second leading cause of death worldwide. In Norwegian men, prostate cancer (PCa) was the most commonly diagnosed cancer and second most frequent cause of cancer death in 2017. The tumor microenvironment (TME), ...
Genetic and molecular analysis of the functional role of the AGL36 MADS-box Type I transcription factor Restricted Access
(Master thesis / Masteroppgave, 2014)
In angiosperms, seed development is a tightly regulated process often involving different epigenetic mechanisms such as a phenomenon known as imprinting that regulates parental gene expression in a parent-of-origin-dependent ...
(Master thesis / Masteroppgave, 2019)
Whole exome sequencing was performed to identify putative disease-causing variants in a girl with macrocephaly, epilepsy and severe mental retardation, who had an unknown molecular diagnosis. Compound heterozygous SZT2 ...
Characterization of CD276 (B7-H3) in Human Metastatic Melanoma Functions and Interaction Partners Restricted Access
(Master thesis / Masteroppgave, 2015)
(Master thesis / Masteroppgave, 2014)
Tuberculosis (TB), caused by Mycobacterium tuberculosis, has been treated with the same arsenal of antibiotics since the 1970 s; and with an estimated one third of the world s population latently infected at the moment, ...
Role of the endolysosomal and autophagosomal pathways in degradation of the gap junction protein connexin 43 Restricted Access
(Master thesis / Masteroppgave, 2014)
(Master thesis / Masteroppgave, 2014)
(Master thesis / Masteroppgave, 2021)
In this study, we assessed the potential synergistic effects of XBP1 and ATF4 on cell growth in two different PCa cell lines. Through simultaneous siRNA-mediated knockdown of ATF4 and total XBP1, we analyzed effects on ...
(Master thesis / Masteroppgave, 2016)
Novel mechanisms of tumor suppression by the miR-34 family Restricted Access
(Master thesis / Masteroppgave, 2015)
(Master thesis / Masteroppgave, 2015)
Malignant melanoma is an aggressive type of skin cancer which urgently requires new and efficient treatment strategies. A novel targeted agent for advanced melanoma, vemurafenib, has shown high response rates among patients ...
Exploring the role of c-Myb and its co-activators, FLASH and ATF7IP, in histone gene expression Restricted Access
(Master thesis / Masteroppgave, 2015)
Atg8 Proteins in Autophagy and Death Receptor-Induced Apoptosis in Prostate Cancer Cells Restricted Access
(Master thesis / Masteroppgave, 2015)
Autophagy and apoptosis are two important cellular processes, whose dysfunctions are involved in many severe diseases, including cancer. Bulk autophagy is typically mediated by the sequestration of cytoplasmic material ...
(Master thesis / Masteroppgave, 2015)
(Master thesis / Masteroppgave, 2015)
Mitochondrial disorders constitute a clinically and genetically heterogeneous group of diseases that arise as a result of dysfunction of the mitochondrial respiratory chain. They can be caused by mutations in either the ...
DNA damage signalling factors protecting cancer cells against hypoxia-induced replication stress Restricted Access
(Master thesis / Masteroppgave, 2015)
(Master thesis / Masteroppgave, 2015)
The vertebrate immune system is an enormously complex arrangement of a large number of interdependent cell types, responsible for fending off harmful invasive organisms as well as aberrant cells within the host itself. The ...
The SW480 and SW620 cell lines as a model system for studying epithelial to mesenchymal transition (EMT) in colorectal cancer Restricted Access
(Master thesis / Masteroppgave, 2015)
Characterisation of a Potential Prognostic Factor in Breast Cancer Restricted Access
(Master thesis / Masteroppgave, 2015)
(Master thesis / Masteroppgave, 2019)
Sarcomas arise in patients of all ages and account for approximately 1% of new cancer diagnoses in Norway and the United States. Osteosarcoma is a subtype of sarcoma that typically affects children and adolescents and ...
A novel role for the PNUTS/PP1 interacting proteins WDR82 and TOX4 in the DNA damage response Restricted Access
(Master thesis / Masteroppgave, 2013)
(Master thesis / Masteroppgave, 2013)
Steroide hormone receptors (SHRs) are ligand-modulated transcription factors that regulate important physiological processes. The effects of SHRs are regulated by their coordinated interaction with other transcription ...
Differential effects of bone morphogenetic proteins (BMPs) in human memory B cells Restricted Access
(Master thesis / Masteroppgave, 2013)
(Master thesis / Masteroppgave, 2018)
Utilization of autophagy in the antigen donor cell for enhanced priming of Gag-p24-specific CD8+ T cell responses Restricted Access
(Master thesis / Masteroppgave, 2013)
(Master thesis / Masteroppgave, 2013)
The Casitas B-lineage lymphoma (Cbl) family of ubiquitin ligases has been studied for years regarding their important role in downregulation of ligand bound epidermal growth factor receptor (EGFR). The two isoforms c-Cbl ...
(Master thesis / Masteroppgave, 2013)
Prostate cancer (PCa) is the most common type of cancer among men in Western countries. An approach to better PCa diagnosis, prognosis and management is to identify genes that are prostate-specific and differentially ...
Aberrant m6A regulation in Alkbh5 deficient mice results in increased DNA methylation and altered gene expression Restricted Access
(Master thesis / Masteroppgave, 2013)
Exploring the functional relevance of genetic regions associated with rheumatoid arthritis Restricted Access
(Master thesis / Masteroppgave, 2014)
Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting nearly 1% of the western population. The disease is characterized by a systematic inflammatory process in the synovial joints initiated by the immune ...
Small molecule c-Myc modulator as a potential compound for immunotherapeutic treatment of cancers Restricted Access
(Master thesis / Masteroppgave, 2019)
Development of Novel Treatments for Drug-Resistant Candida Infections Restricted Access
(Master thesis / Masteroppgave, 2019)
Characterization of a peptide-Fc fusion protein Restricted Access
(Master thesis / Masteroppgave, 2018)
(Master thesis / Masteroppgave, 2013)
The WEE1-inhibitor MK-1775 is currently in clinical trials as an anti-cancer drug. In response to DNA damage, human cells activate cell cycle checkpoints to temporarily halt cell cycle progression, and this helps facilitating ...
The potential of tumor-specific Th2 cells for cancer immunotherapy by adoptive transfer Restricted Access
(Master thesis / Masteroppgave, 2013)
Immunotherapy based on adoptive cell transfer (ACT) of tumor-specific T cells, either naturally occurring or gene engineered, represents a promising strategy to cure cancer. To date the majority of ACT trials have focused ...
(Master thesis / Masteroppgave, 2013)
(Master thesis / Masteroppgave, 2013)
Cytokinesis is the final step of cell division that leads to the physical separation of two daughter cells by abscission. It is now well established that several components of endosomal machineries are involved in cytokinesis ...
Expanding the c-Myb interaction network through search for and studies of novel interaction partners Restricted Access
(Master thesis / Masteroppgave, 2013)
SUMMARY
The transcription factor c-Myb is a key regulator of stem- and progenitor cells in the bone marrow, which has the task of forming most of the blood cells. However, maturation, activation and some proliferation of ...
(Master thesis / Masteroppgave, 2013)
Studying the interaction between c-Myb and the menin/MLL system Restricted Access
(Master thesis / Masteroppgave, 2013)
Effects of Bone Morphogenetic Proteins (BMPs) in Human B Lymphocytes Restricted Access
(Master thesis / Masteroppgave, 2013)
(Master thesis / Masteroppgave, 2013)
(Master thesis / Masteroppgave, 2013)
RNA pyrophosphohydrolase (RppH) catalyzes the removal of pyrophosphate from 5' triphosphorylated RNAs thereby initiating RNA degradation. The enzyme has originally been identified in bacteria but homologs are present in ...
Phage library against library for combinatorial discovery of matched target and bait pairs - a proof of principle Restricted Access
(Master thesis / Masteroppgave, 2013)
(Master thesis / Masteroppgave, 2019)
Targeting vaccines to dendritic cells A functional analysis of human XCL1 and XCL2 in mice Restricted Access
(Master thesis / Masteroppgave, 2013)
The idea of targeting vaccines directly to antigen presenting cells to increase vaccine efficiency has received great attention in recent years, and so has the strategy of further tailoring the vaccine to elicit a desired ...
Bruk immun celler som prognose for ikke-småcellet lungekreft Restricted Access
(Master thesis / Masteroppgave, 2014)
Lungekreft representerer den hyppigste årsaken til kreft-dødsfall i Norge. Ikke-småcellet lungekreft (NSCLC) er den viktigste under typen av lungekreft. Det er ca 2500 pasienter diagnostisert med NSCLC og 2100 dødsfall i ...
(Master thesis / Masteroppgave, 2014)
(Master thesis / Masteroppgave, 2015)
We have studied changes in the Golgi morphology in Madin-Darby canine kidney cells as a result of chemically induced DNA damage, and how such morphological change affects synthesis and sorting of sulphated PGs in the cell line.
(Master thesis / Masteroppgave, 2014)
The role of evectin-2 and its binding partner PS in toxin transport Restricted Access
(Master thesis / Masteroppgave, 2014)
Tools for ESCRT protein studies - Visualising the invisible Restricted Access
(Master thesis / Masteroppgave, 2014)
Endosomal internalisation and subsequent lysosomal degradation of membrane proteins is important for regulation of multiple cellular processes, among these the termination of receptor signalling and degradation of misfolded ...
Human Neil DNA glycosylases - crystal screening, biochemical characterization and inhibitor screening Restricted Access
(Master thesis / Masteroppgave, 2014)
(Master thesis / Masteroppgave, 2014)
(Master thesis / Masteroppgave, 2014)
(Master thesis / Masteroppgave, 2018)
Chronic lymphocytic leukemia (CLL) is a mature B-cell malignancy that most often affects the elderly. CLL cells depend on their microenvironment for their extended growth and survival. CLL cells are difficult to grow “in ...
A Structural and Functional Characterisation of Human PGM1 Restricted Access
(Master thesis / Masteroppgave, 2015)
Congenital disorders of glycosylation are a multifaceted group of disorders affecting mul- tiple organs with phenotypes ranging from mild to severe.Congenital disorders of glycosylation are a multifaceted group of disorders ...
Exploring the kinase GCN2 and what activates it Restricted Access
(Master thesis / Masteroppgave, 2015)
(Master thesis / Masteroppgave, 2015)
Heterodimeric ACID/BASE vaccine molecules: The influence of one versus two antigenic units on humoral responses Restricted Access
(Master thesis / Masteroppgave, 2015)
Effects of di-n-butyl phthalate (DBP) on THP-1-derived macrophages Restricted Access
(Master thesis / Masteroppgave, 2015)
Phthalates are chemicals used as plasticizers in various plastics and consumer products, including PVC products, personal care products and pharmaceutical applicants. These chemicals may migrate into the environment, food ...
New insights into the regulation of the gap junction protein connexin43 by the E3 ubiquitin ligase Nedd4-1 Restricted Access
(Master thesis / Masteroppgave, 2015)
Expression dynamics of long non-coding RNAs in the sponge Sycon ciliatum Restricted Access
(Master thesis / Masteroppgave, 2015)
In this thesis I present new data on long non-coding RNAs (lncRNAs) from one of the earliest diverging lineages in the animal kingdom. The ultimate motivation for this work was to understand how unicellular eukaryotes ...
(Master thesis / Masteroppgave, 2015)
The verification of the protein content in membrane fractions after separation of Gram-negative bacterial membranes is to date a tedious and demanding process. With this project, we wanted to create Escherichia coli (E. ...
A study on N-glycosylation of the neonatal Fc receptor Restricted Access
(Master thesis / Masteroppgave, 2015)
Summary The neonatal Fc receptor (FcRn) is a major histocompatibility complex class-I related molecule that plays a key role in in several immunological and non-immunological processes, such as transfer of immunoglobulin ...
O-linket protein glykosylering: en studie av genotype, fenotype og glykan diversitet i afrikanske meningokokkstammer Restricted Access
(Master thesis / Masteroppgave, 2015)
Neisseriaceae er en familie med Gram-negative bakterier som består av både patogene og ikke-patogene bakterier. De to viktigste sykdomsfremkallende er meningokokker (Neisseria meningitidis), som kan forårsake meningokokksykdom ...
The Effect of Transcorneal Electrical Stimulation on the Electroretinogram in Patients with Retinitis Pigmentosa Restricted Access
(Master thesis / Masteroppgave, 2013)
Retinitis Pigmentosa (RP) is a progressive and degrading illness impairing the vision of all age groups [1-3]. The disease is caused by mutations which are affecting the photoreceptors and the retinal pigment epithelium ...
(Master thesis / Masteroppgave, 2019)
Characterization of the substrate interaction sites in factor seven activating protease (FSAP) Restricted Access
(Master thesis / Masteroppgave, 2022)
(Master thesis / Masteroppgave, 2015)
(Master thesis / Masteroppgave, 2015)
In aquaculture today, vaccination of farmed fish is successfully providing protection against many of the most common pathogens. However, while vaccines are most commonly given as a single injection, this is not the ideal ...
(Master thesis / Masteroppgave, 2019)
Gram-negative bacteria use different protein secretion systems, ranging from type I through type IX, to invade the host and cause infections. Proteins of the type V secretion system, called autotransporters, can autonomously ...
Role of the Ikaros target gene Ctnnd1 in B cell development and Ikaros-mediated tumor suppression Restricted Access
(Master thesis / Masteroppgave, 2015)
(Master thesis / Masteroppgave, 2014)
Lyme borreliosis (LB) is the most frequent human tick-borne disease in Scandinavia. This master thesis is focusing on the Borrelia burgdorferi sensu lato (s.l.) complex, which is the causative agent of LB. Today, the B. ...
(Master thesis / Masteroppgave, 2020)
The surface of Gram-negative bacteria is perforated by β-barrel proteins called outer membrane proteins (OMPs). These β-barrels are integral to the outer membrane (OM) and are essential for the viability of the bacterial ...
(Master thesis / Masteroppgave, 2014)
The four receptor tyrosine kinases of the ErbB family mediate the activation of a complex network of signalling pathways that regulate cell proliferation, differentiation, and survival. Because of their central role in the ...
(Master thesis / Masteroppgave, 2014)
(Master thesis / Masteroppgave, 2016)
The interaction between the hippocampus and parahippocampal region is essential for the processing and storage of episodic memories. Spatial memory is a form of episodic memory, which entails the details of the what, when ...
(Master thesis / Masteroppgave, 2016)
The role of tumor necrosis factor α (TNFα) in regulation of connexin43 ubiquitination, endocytosis and degradation Restricted Access
(Master thesis / Masteroppgave, 2016)
(Master thesis / Masteroppgave, 2022)
Possible mechanisms for Ikaros tumour suppressor function in acute lymphoblastic leukaemia. Restricted Access
(Master thesis / Masteroppgave, 2015)