Browsing Institutt for biovitenskap by Author "Eskeland, Ragnhild"
Now showing items 1-15 of 15
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Samara, Athina; Spildrejorde, Mari; Sharma, Ankush; Falck, Martin; Leithaug, Magnus; Modafferi, Stefania; Bjørnstad, Pål Marius; Ganesh, Acharya; Gervin, Kristina; Lyle, Robert; Eskeland, Ragnhild (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)Neuronal differentiation of pluripotent stem cells is an established method to study physiology, disease, and medication safety. However, the sequence of events in human neuronal differentiation and the ability of in vitro ...
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Bengtsen, Mads; Klepper, Kjetil; Gundersen, Sveinung; Cuervo, Ignacio; Drabløs, Finn; Hovig, Johannes Eivind; Sandve, Geir Kjetil F.; Gabrielsen, Odd Stokke; Eskeland, Ragnhild (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)Strict control of tissue-specific gene expression plays a pivotal role during lineage commit- ment. The transcription factor c-Myb has an essential role in adult haematopoiesis and func- tions as an oncogene when rearranged ...
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Fuglerud, Bettina Maria; Lemma, Roza Berhanu; Wanichawan, Pimthanya; Sundaram, Arvind; Eskeland, Ragnhild; Gabrielsen, Odd Stokke (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)The transcription factor c-Myb is involved in early differentiation and proliferation of haematopoietic cells, where it operates as a regulator of self-renewal and multi-lineage differentiation. Deregulated c-Myb plays ...
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Lemma, Roza Berhanu; Ledsaak, Marit; Fuglerud, Bettina Maria; Sandve, Geir Kjetil; Eskeland, Ragnhild; Gabrielsen, Odd Stokke (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)The transcription factor MYB is a master regulator in haematopoietic progenitor cells and a pioneer factor affecting differentiation and proliferation of these cells. Leukaemic transformation may be promoted by high MYB ...
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Fleischer, Thomas; Tekpli, Xavier; Mathelier, Anthony; Wang, Shixiong; Nebdal, Daniel J.H.; Dhakal, Hari Prasad; Sahlberg, Kristine Kleivi; Schlichting, Ellen; Børresen-Dale, Anne-Lise; Borgen, Elin; Naume, Bjørn; Eskeland, Ragnhild; Frigessi, Arnoldo; Tost, Jörg; Rodriguez, Antoni Hurtado; Kristensen, Vessela N. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)Breast cancers exhibit genome-wide aberrant DNA methylation patterns. To investigate how these affect the transcriptome and which changes are linked to transformation or progression, we apply genome-wide expression–methylation ...
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Gervin, Kristina; Nordeng, Hedvig Marie Egeland; Eskeland, Ragnhild; Paulsen, Ragnhild Elisabeth; Lyle, Robert (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)Epigenetikk er læren om arvelige mekanismer som regulerer aktiviteten til genene i ulike celler og vev som ikke involverer en endring i selve DNA-sekvensen. Om gener er skrudd av eller på er bestemt av epigenetiske merkelapper ...
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Simovski, Boris; Vodak, Daniel; Gundersen, Sveinung; Domanska, Diana Ewa; Azab, Abdulrahman; Holden, Lars; Holden, Marit; Grytten, Ivar; Rand, Knut Dagestad; Drabløs, Finn Sverre; Johansen, Morten; Mora, Antonio M.; Lund-Andersen, Christin; Fromm, Bastian; Eskeland, Ragnhild; Gabrielsen, Odd Stokke; Ferkingstad, Egil; Nakken, Sigve; Bengtsen, Mads; Nederbragt, Alexander Johan; Thorarensen, Hildur Sif; Andreas Akse, Johannes; Glad, Ingrid Kristine; Hovig, Johannes Eivind; Sandve, Geir Kjetil (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)Background: Recent large-scale undertakings such as ENCODE and Roadmap Epigenomics have generated experimental data mapped to the human reference genome (as genomic tracks) representing a variety of functional elements ...
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Maclennan, Marie; García-Cañadas, Marta; Reichmann, Judith; Khazina, Elena; Wagner, Gabriele; Playfoot, Christopher J.; Salvador-Palomeque, Carmen; Mann, Abigail R.; Peressini, Paula; Sanchez, Laura; Dobie, Karen; Read, David; Hung, Chao-Chun; Eskeland, Ragnhild; Meehan, Richard R.; Weichenrieder, Oliver; García-Pérez, Jose Luis; Adams, Ian R. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)Mobilization of retrotransposons to new genomic locations is a significant driver of mammalian genome evolution, but these mutagenic events can also cause genetic disorders. In humans, retrotransposon mobilization is ...
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Spildrejorde, Mari; Samara, Athina; Sharma, Ankush; Leithaug, Magnus; Falck, Martin; Modafferi, Stefania; Sundaram, Arvind; Acharya, Ganesh Prasad; Nordeng, Hedvig Marie Egeland; Eskeland, Ragnhild; Gervin, Kristina; Lyle, Robert (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)Prenatal paracetamol exposure has been associated with neurodevelopmental outcomes in childhood. Pharmacoepigenetic studies show differences in cord blood DNA methylation between unexposed and paracetamol-exposed neonates, ...
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Lemma, Roza Berhanu; Ledsaak, Marit; Fuglerud, Bettina Maria; Rodríguez-Castañeda, Fernando; Eskeland, Ragnhild; Gabrielsen, Odd Stokke (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)SUMOylation is a post-translational modification frequently found on nuclear proteins, including transcription factors (TFs) and coactivators. By controlling the activity of several TFs, SUMOylation may have far-reaching ...
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Lemma, Roza B.; Fleischer, Thomas; Martinsen, Emily; Ledsaak, Marit; Kristensen, Vessela; Eskeland, Ragnhild; Gabrielsen, Odd S.; Mathelier, Anthony (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)Methylation of cytosines on DNA is a prominent modification associated with gene expression regulation. Aberrant DNA methylation patterns have recurrently been linked to dysregulation of the regulatory program in cancer ...
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Samara, Athina; Falck, Martin; Spildrejorde, Mari; Leithaug, Magnus; Acharya, Ganesh; Lyle, Robert; Eskeland, Ragnhild (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)Here, we describe a protocol for rapid neuronal differentiation from human embryonic stem cells (hESCs) toward a heterogenous population of telencephalic progenitors, immature and mature neurons, for drug-screening and ...
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Sharma, Ankush; Akshay, Akshay; Rogne, Marie; Eskeland, Ragnhild (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)Motivation: Mapping of chromatin accessibility landscapes in single-cells and the integration with gene expression enables a better understanding of gene regulatory mechanisms defining cell identities and cell-fate ...
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Rodriguez- Castañeda, Fernando; Lemma, Roza Berhanu; Cuervo Torre, Ignacio; Bengtsen, Mads; Moen, Lisa Marie; Ledsaak, Marit; Eskeland, Ragnhild; Gabrielsen, Odd Stokke (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)The small ubiquitin-like modifier (SUMO) post-translationally modifies lysine residues of transcription factors and co-regulators and thereby contributes to an important layer of control of the activities of these ...
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Fuglerud, Bettina M; Ledsaak, Marit; Rogne, Marie; Eskeland, Ragnhild; Gabrielsen, Odd S (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)Background The concept of pioneer transcription factors is emerging as an essential part of the epigenetic regulation, taking place during cell development and differentiation. However, the precise molecular ...