Browsing CRIStin høstingsarkiv by Author "Isayev, Olexandr"

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  • Crowdsourced mapping of unexplored target space of kinase inhibitors 
    Cichonska, Anna; Ravikumar, Balaguru; Allaway, Robert J.; Wan, Fangping; Park, Sungjoon; Isayev, Olexandr; Li, Shuya; Mason, Michael; Lamb, Andrew; Tanoli, Ziaurrehman; Jeon, Minji; Kim, Sunkyu; Popova, Mariya; Capuzzi, Stephen; Zeng, Jianyang; Dang, Kristen; Koytiger, Gregory; Kang, Jaewoo; Wells, Carrow I.; Willson, Timothy M.; Oprea, Tudor I; Schlessinger, Avner; Drewry, David H.; Stolovitzky, Gustavo; Wennerberg, Krister; Guinney, Justin; Aittokallio, Tero Antero (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Abstract Despite decades of intensive search for compounds that modulate the activity of particular protein targets, a large proportion of the human kinome remains as yet undrugged. Effective approaches are therefore ...