Finn forfatter "O'Connell, Kevin Sean"

Viser treff 21-28 av 28

  • Leveraging genetic overlap between irritability and psychiatric disorders to identify genetic variants of major psychiatric disorders 
    Jung, Kyeongmin; Yoon, Joohyun; Ahn, Yeeun; Kim, Soyeon; Shim, Injeong; Ko, Hyunwoong; Jung, Sang-Hyuk; Kim, Jaeyoung; Kim, Hyejin; Lee, Dong June; Cha, Soojin; Lee, Hyewon; Kim, Beomsu; Cho, Min Young; Cho, Hyunbin; Kim, Dan Say; Kim, Jinho; Park, Woong-Yang; Park, Tae Hwan; O'Connell, Kevin Sean; Andreassen, Ole; Myung, Woojae; Won, Hong-Hee (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Abstract Irritability is a heritable core mental trait associated with several psychiatric illnesses. However, the genomic basis of irritability is unclear. Therefore, this study aimed to 1) identify the genetic variants ...
  • Polygenic overlap with body-mass index improves prediction of treatment-resistant schizophrenia 
    O'Connell, Kevin Sean; Koch, Elise; Lenk, Hasan Cagin; Akkouh, Ibrahim Ahmed; Hindley, Guy Frederick Lanyon; Jaholkowski, Piotr Pawel; Smith, Robert Løvsletten; Holen, Børge; Shadrin, Alexey; Frei, Oleksandr; Smeland, Olav Bjerkehagen; Steen, Nils Eiel; Dale, Anders M; Molden, Espen; Djurovic, Srdjan; Andreassen, Ole (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Treatment resistant schizophrenia (TRS) is characterized by repeated treatment failure with antipsychotics. A recent genome-wide association study (GWAS) of TRS showed a polygenic architecture, but no significant loci were ...
  • Shared genetic architecture between neuroticism, coronary artery disease and cardiovascular risk factors 
    Torgersen, Kristin Stensland; Bahrami, Shahram; Frei, Oleksandr; Shadrin, Alexey; O'Connell, Kevin Sean; Smeland, Olav Bjerkehagen; Munkhaugen, John; Djurovic, Srdjan; Dammen, Toril; Andreassen, Ole A. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Abstract Neuroticism is associated with poor health, cardiovascular disease (CVD) risk factors and coronary artery disease (CAD). The conditional/conjunctional false discovery rate method (cond/conjFDR) was applied to ...
  • Shared genetic architecture between schizophrenia and subcortical brain volumes implicates early neurodevelopmental processes and brain development in childhood 
    Cheng, Weiqiu; van der Meer, Dennis; Parker, Nadine; Hindley, Guy Frederick Lanyon; O'Connell, Kevin Sean; Wang, Yunpeng; Shadrin, Alexey; Alnæs, Dag; Bahrami, Shahram; Lin, Aihua; Karadag, Naz; Holen, Børge; Fernández-Cabello, Sara; Fan, Chun-Chieh; Dale, Anders; Djurovic, Srdjan; Westlye, Lars Tjelta; Frei, Oleksandr; Smeland, Olav Bjerkehagen; Andreassen, Ole (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2022)
    Patients with schizophrenia have consistently shown brain volumetric abnormalities, implicating both etiological and pathological processes. However, the genetic relationship between schizophrenia and brain volumetric ...
  • Shared genetic loci between depression and cardiometabolic traits 
    Torgersen, Kristin Stensland; Rahman, Zillur; Bahrami, Shahram; Hindley, Guy Frederick Lanyon; Parker, Nadine; Frei, Oleksandr; Shadrin, Alexey; O'Connell, Kevin Sean; Tesli, Martin Steen; Smeland, Olav Bjerkehagen; Munkhaugen, John; Djurovic, Srdjan; Dammen, Toril; Andreassen, Ole (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Epidemiological and clinical studies have found associations between depression and cardiovascular disease risk factors, and coronary artery disease patients with depression have worse prognosis. The genetic relationship ...
  • Systemic Cell Adhesion Molecules in Severe Mental Illness: Potential Role of Intercellular CAM-1 in Linking Peripheral and Neuroinflammation 
    Sheikh, Mashhood Ahmed; O'Connell, Kevin Sean; Lekva, Tove; Szabo, Attila; Akkouh, Ibrahim Ahmed; Osete, Jordi Requena; Agartz, Ingrid; Engh, John; Andreou, Dimitrios; Boye, Birgitte; Bøen, Erlend; Elvsåshagen, Torbjørn; Hope, Sigrun; Werner, Maren Caroline Frogner; Joa, Inge; Johnsen, Erik; Kroken, Rune Andreas; Lagerberg, Trine Vik; Melle, Ingrid; Drange, Ole Kristian; Morken, Gunnar; Nærland, Terje; Sørensen, Kjetil; Vaaler, Arne; Weibell, Melissa Anne Elin Authen; Westlye, Lars Tjelta; Aukrust, Pål; Djurovic, Srdjan; Steen, Nils Eiel; Andreassen, Ole; Ueland, Thor (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Background Cell adhesion molecules (CAMs) orchestrate leukocyte trafficking and could link peripheral and neuroinflammation in patients with severe mental illness (SMI), by promoting inflammatory and immune-mediated ...
  • The relationship between cannabis use, schizophrenia, and bipolar disorder: a genetically informed study 
    Cheng, Weiqiu; Parker, Nadine; Karadag, Naz; Koch, Elise; Hindley, Guy Frederick Lanyon; Icick, Romain; Shadrin, Alexey; O'Connell, Kevin Sean; Bjella, Thomas; Bahrami, Shahram; Rahman, Zillur; Woldeyohannes, Markos Tesfaye; Jaholkowski, Piotr Pawel; Rødevand, Linn; Holen, Børge; Lagerberg, Trine Vik; Steen, Nils Eiel; Djurovic, Srdjan; Dale, Anders M; Frei, Oleksandr; Smeland, Olav Bjerkehagen; Andreassen, Ole (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2023)
    Background The relationship between psychotic disorders and cannabis use is heavily debated. Shared underlying genetic risk is one potential explanation. We investigated the genetic association between psychotic disorders ...
  • The shared genetic basis of mood instability and psychiatric disorders: A cross-trait genome-wide association analysis 
    Hindley, Guy Frederick Lanyon; O'Connell, Kevin Sean; Rahman, Zillur; Frei, Oleksandr; Bahrami, Shahram; Shadrin, Alexey; Høegh, Margrethe Collier; Cheng, Weiqiu; Karadag, Naz; Lin, Aihua; Rødevand, Linn; Fan, Chun C.; Djurovic, Srdjan; Lagerberg, Trine Vik; Dale, Anders; Smeland, Olav Bjerkehagen; Andreassen, Ole (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Recent genome-wide association studies of mood instability (MOOD) have found significant positive genetic correlation with major depression (DEP) and weak correlations with other psychiatric disorders. We investigated the ...