Browsing Institutt for informatikk by Author "Rada, Cristina"

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  • The uracil-DNA glycosylase UNG protects the fitness of normal and cancer B cells expressing AID 
    Safavi, Shiva; Larouche, Ariane; Zahn, Astrid; Patenaude, Anne-Marie; Domanska, Diana Ewa; Dionne, Kiersten; Rognes, Torbjørn; Dingler, Felix; Kang, Seong-Kwi; Liu, Yan; Johnson, Nathalie; Hébert, Josée; Verdun, Ramiro E.; Rada, Cristina; Vega, Francisco; Nilsen, Hilde; Di Noia, Javier M. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Abstract In B lymphocytes, the uracil N-glycosylase (UNG) excises genomic uracils made by activation-induced deaminase (AID), thus underpinning antibody gene diversification and oncogenic chromosomal translocations, ...
  • Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG 
    Alsøe, Lene; Sarno, Antonio; Carracedo Huroz, Sergio; Domanska, Diana Ewa; Dingler, Felix; Lirussi, Lisa; Sengupta, Tanima; Tekin, Nuriye Basdag; Jobert, Laure; Alexandrov, Ludmil B.; Galashevskaya, Anastasia; Rada, Cristina; Sandve, Geir Kjetil; Rognes, Torbjørn; Krokan, Hans Einar; Nilsen, Hilde Loge (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Both a DNA lesion and an intermediate for antibody maturation, uracil is primarily processed by base excision repair (BER), either initiated by uracil-DNA glycosylase (UNG) or by single-strand selective monofunctional ...