dc.date.accessioned | 2013-03-12T12:41:25Z | |
dc.date.available | 2013-03-12T12:41:25Z | |
dc.date.issued | 2007 | en_US |
dc.date.submitted | 2007-10-29 | en_US |
dc.identifier.citation | Karimzadeh, Mehran. Diagnostic accuracy of fine-needle aspiration cytology in histological grade 1 breast carcinomas: are we good enough?. Prosjektoppgave, University of Oslo, 2007 | en_US |
dc.identifier.uri | http://hdl.handle.net/10852/29624 | |
dc.description.abstract | BACKGROUND: Fine-needle aspiration cytology (FNAC) of both palpable and non-palpable breast carcinomas has a high accuracy and sensitivity in dedicated centres. It is generally though that low-grade carcinomas have a distinctly lower sensitivity due to a discrete cellular atypia that might be difficult to appreciate. Grade 1 carcinomas make up about 45 % of screening detected breast carcinomas and about 20 % of symptomatic breast cancers. The aim of this study was to evaluate the diagnostic sensitivity of G1 carcinomas and identify the critical features in the cytological diagnostic work-up of these tumours.
MATERIAL AND METHODS: There were FNAC smears from 494 histologically confirmed grade 1 carcinomas diagnosed during 1996-2004. The cytological diagnoses were compared with the histology.
RESULTS: A definitive malignant diagnosis was given in 382 cases (77.3 %). 16.2 % were diagnosed as equivocal or suspicious, 4.8 % had been given a benign or probable benign diagnosis (false negatives). 13 cases (2.6 %) were unsatisfactory. The complete sensitivity was 92.7%. Invasive ductal carcinomas comprised 81.3 % of all cases. A definite malignant preoperative diagnosis was given in 80.8 % of these. Invasive lobular and tubular carcinomas comprised 7.1 % and 5.5 % of cases, respectively. They received a definitive, malignant preoperative diagnosis in 51.4 % and 55.6 %, respectively.
CONCLUSION: Preoperative FNAC diagnosis of grade 1 breast carcinoma has a high accuracy and sensitivity, especially in ductal carcinomas. Invasive lobular and tubular carcinomas receive a definite preoperative diagnosis in about 50 % of the cases. The main reason for not reaching a definitive malignant diagnosis was sampling error due to small tumours < 1 cm in diameter, irrespective of tumour subtype.
Key words: breast carcinoma, grading, fine needle aspiration, grade 1 carcinoma, pleomorphism, nuclear size, dissociation pattern. | nor |
dc.language.iso | eng | en_US |
dc.subject | patologi | |
dc.title | Diagnostic accuracy of fine-needle aspiration cytology in histological grade 1 breast carcinomas: are we good enough? | en_US |
dc.type | Master thesis | en_US |
dc.date.updated | 2007-11-19 | en_US |
dc.creator.author | Karimzadeh, Mehran | en_US |
dc.subject.nsi | VDP::719 | en_US |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft.au=Karimzadeh, Mehran&rft.title=Diagnostic accuracy of fine-needle aspiration cytology in histological grade 1 breast carcinomas: are we good enough?&rft.inst=University of Oslo&rft.date=2007&rft.degree=Prosjektoppgave | en_US |
dc.identifier.urn | URN:NBN:no-17065 | en_US |
dc.type.document | Prosjektoppgave | en_US |
dc.identifier.duo | 66889 | en_US |
dc.contributor.supervisor | Toril Sauer | en_US |
dc.identifier.bibsys | 071681868 | en_US |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/29624/3/ProsjektMehran.pdf | |