dc.date.accessioned | 2013-03-12T12:35:16Z | |
dc.date.available | 2013-09-17T22:30:34Z | |
dc.date.issued | 2008 | en_US |
dc.date.submitted | 2008-04-04 | en_US |
dc.identifier.citation | Njerve, Ida Unhammer, Kase, Marte Tranheim, . Clopidogrel non- responsiveness in patients with coronary heart disease. Prosjektoppgave, University of Oslo, 2008 | en_US |
dc.identifier.uri | http://hdl.handle.net/10852/29268 | |
dc.description.abstract | Summary
Background
Clopidogrel is an antiplatelet drug, blocking the ADP-pathway of platelet activation. Currently there is no universally accepted definition of clopidogrel non- responsiveness.
The difference between pre-treatment and posttreatment ADP- induced platelet aggregation has been used as an estimate of clopidogrel non- responsiveness.
The aim of the present study was to define a cut- off point for clopidogrel non- responsiveness in a study population of patients with stable coronary heart disease (CHD), and possibly give an estimation of the prevalence of non- responders in patients with stable CHD.
Methods
The study population consists of 227 consecutively enrolled patients from the ASCET-study, all treated with ASA, of which 91 were later randomized to clopidogrel. Analysis on venous blood samples were performed using VerifyNow P2Y12 assay, which measures ADP-induced platelet aggregation. We performed descriptive statistics on the outcome.
Results
The 5% percentile of Platelet Reaction Units (PRU) at baseline was close to 170, and we used this as our cut- off- point for non- responsiveness. The equivalent 95% percentile value in % inhibition was 24%. After one month on clopidogrel treatment, we calculated a prevalence of non- responsiveness to clopidogrel of 35% and 28% for PRU and % inhibition respectively.
Conclusions
We found a frequency of clopidogrel non- responsiveness (28-35%) that corresponds with current literature (5-44%). As ex vivo platelet function tests not necessarily give an accurate measurement of in vivo platelet function, clinical non- responsiveness needs to be explored in larger prospective studies. | nor |
dc.language.iso | eng | en_US |
dc.subject | indremedisin | |
dc.title | Clopidogrel non- responsiveness in patients with coronary heart disease | en_US |
dc.type | Master thesis | en_US |
dc.date.updated | 2008-04-30 | en_US |
dc.creator.author | Njerve, Ida Unhammer | en_US |
dc.creator.author | Kase, Marte Tranheim | en_US |
dc.subject.nsi | VDP::770 | en_US |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft.au=Njerve, Ida Unhammer&rft.au=Kase, Marte Tranheim&rft.title=Clopidogrel non- responsiveness in patients with coronary heart disease&rft.inst=University of Oslo&rft.date=2008&rft.degree=Prosjektoppgave | en_US |
dc.identifier.urn | URN:NBN:no-18855 | en_US |
dc.type.document | Prosjektoppgave | en_US |
dc.identifier.duo | 71632 | en_US |
dc.contributor.supervisor | Arnesen, Harald og Seljeflot, Ingebjørg | en_US |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/29268/3/Prosjektxnjerve.pdf | |