dc.date.accessioned | 2013-03-12T12:35:33Z | |
dc.date.available | 2013-03-12T12:35:33Z | |
dc.date.issued | 2010 | en_US |
dc.date.submitted | 2010-10-05 | en_US |
dc.identifier.citation | Lindstad, Christian Borgen. Hypertensjon med fokus på refraktær hypertensjon og primær hyperaldosteronisme. Beskrivelse av døgnprofil ved ambulatoriske blodtrykksmålinger hos en gruppe refraktært hypertensive pasienter. Prosjektoppgave, University of Oslo, 2010 | en_US |
dc.identifier.uri | http://hdl.handle.net/10852/29128 | |
dc.description.abstract | Hypertension
with focus on refractory hypertension and primary hyperaldosteronism. 24 hour profile of ambulatory blood pressure measurements in a group of refractory hypertensive patients.
Background: Arterial hypertension is a common risk factor causing much morbidity and mortality. An uncommon but significant cause of hypertension is primary hyperaldosteronism. Reduced nocturnal fall in blood pressure (non-dipping) has been associated with increased cardiovascular morbidity. The objectives of this paper was 1: to give an introduction to hypertension with special focus on primary hyperaldosteronism and 2: to characterize the 24 hour blood pressure profile of a group of refractory hypertensive patients with focus on nocturnal dip. Methods: Patients with refractory hypertension underwent ambulatory blood pressure monitoring and were followed up as outpatients. Results: We had valid data from 63 patients of whom most had low plasma levels of renin. Patients were grouped according to their nocturnal fall in systolic blood pressure into dippers (>10% fall), non-dippers (<10% fall) and inverted dippers. The size of the systolic dip was strongly correlated to the size of the diastolic dip. There were significant differences between the groups for the following parameters: nocturnal systolic blood pressure, diurnal and nocturnal diastolic blood pressure and nocturnal middle arterial pressure. Discussion: Totally 42 (67%) of the patients had a nocturnal dip of less than 10%, which is a high percentage compared to studies of essential hypertensive patients. This finding might indicate that treatment resistance could be a contributing factor in reducing nocturnal dipping. Reduced dipping status has been associated with increased cardiovascular morbidity, but whether medical reversion of the dipping pattern reduces the cardiovascular risk is a question to be answered in future studies. | eng |
dc.language.iso | nob | en_US |
dc.subject | indremedisin | |
dc.title | Hypertensjon med fokus på refraktær hypertensjon og primær hyperaldosteronisme. Beskrivelse av døgnprofil ved ambulatoriske blodtrykksmålinger hos en gruppe refraktært hypertensive pasienter | en_US |
dc.type | Master thesis | en_US |
dc.date.updated | 2011-05-06 | en_US |
dc.creator.author | Lindstad, Christian Borgen | en_US |
dc.subject.nsi | VDP::770 | en_US |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft.au=Lindstad, Christian Borgen&rft.title=Hypertensjon med fokus på refraktær hypertensjon og primær hyperaldosteronisme. Beskrivelse av døgnprofil ved ambulatoriske blodtrykksmålinger hos en gruppe refraktært hypertensive pasienter&rft.inst=University of Oslo&rft.date=2010&rft.degree=Prosjektoppgave | en_US |
dc.identifier.urn | URN:NBN:no-26254 | en_US |
dc.type.document | Prosjektoppgave | en_US |
dc.identifier.duo | 106050 | en_US |
dc.contributor.supervisor | Professor dr. med Ingrid Os, Nyremedisinsk avdeling, Ullevål Universitetssykehus | en_US |
dc.identifier.bibsys | 112399142 | en_US |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/29128/1/ChristianBLindstadsprosjektoppgave.pdf | |