| dc.date.accessioned | 2013-03-12T12:17:34Z | |
| dc.date.available | 2013-03-12T12:17:34Z | |
| dc.date.issued | 2011 | en_US |
| dc.date.submitted | 2011-04-06 | en_US |
| dc.identifier.citation | Brean, Are. Idiopathic normal pressure hydrocephalus in neurological practice. Doktoravhandling, University of Oslo, 2011 | en_US |
| dc.identifier.uri | http://hdl.handle.net/10852/27953 | |
| dc.description.abstract | Aims:The aims of this thesis are to estimate the epidemiology of iNPH in a Norwegian population compared to the incidence of surgery for the condition, to assess whether lumbar measurements of cerebrospinal fluid pressure (CSFP) concurs with intracranial pressure (ICP), and with the clinical response to shunting, and finally to assess which of the lumbar hydrodynamic measurements that best can predict the clinical response to shunting.
Methods:The thesis consists of six publications. Publication Iassesses the prevalence of iNPH in a Norwegian population. Publication IIassesses the five year incidence of surgery for iNPH in Norway. Publication III compareslumbarCSFP waves versus ICPwaves in iNPH. Publication IV compares ICPmeasured simultaneously within the brain parenchyma and cerebral ventricles.Publication Vassesses the role of lumbar infusion testing for referral of iNPH patients to neurosurgery. Publication VI assesses whether CSFP waveamplitude during lumbar infusion in iNPH can predict response to shunting.
Results: We found a prevalence of probable iNPH of 21.9/100.000 inhabitants,and an incidence of 5.5/100.000/year. The total rate of surgery for iNPH was 1.09/100.000/year. The lumbar CSFP wave amplitude during lumbar infusion could be used to predict the ICP wave amplitude during over-night monitoring of the intracranial pressure. There is no pressure gradient between pressure wave amplitudes derived from brain parenchyma and ventricular CSF. Resistance to outflow (Rout) and CSFP wave amplitude derived from lumbar infusion related only weakly, while shunt response related highly to the quantitative distribution of CSFP wave amplitudes during infusion, giving false negative results in 16% of the patients. Elevated CSFP wave amplitudes during lumbar infusion predictedshunt response with asensitivity of 88 and aspecificity of 60.
Conclusions:Our data suggest that too few patients are being offered surgical treatment for iNPH in Norway. Lumbar CSFP wave amplitudes concur to a great extent with ICP wave amplitudes and with clinical response to shunting. Lumbar CSFP wave amplitudes predict clinical response to shunting better than Rout, but further studies are advocated to address the problem of false negative results from lumbar hydrodynamic measurements. | eng |
| dc.language.iso | eng | en_US |
| dc.relation.haspart | Paper I: Brean A, Eide PK: Prevalence of probable idiopathic normal pressure hydrocephalus (iNPH) in a Norwegian population. Acta Neurologica Scandinavica 118(1): 48-53, 2008. The paper is removed from the thesis in DUO due to publisher restrictions. The published version is available at: https://doi.org/10.1111/j.1600-0404.2007.00982.x | |
| dc.relation.haspart | Paper II: Brean A, Fredø HL, Sollid S, Müller T, Sundstrøm T, Eide PK: Five-year incidence of surgery for idiopathic normal pressure hydrocephalus in Norway. Acta Neurologica Scandinavica 120(5): 314-316, 2009. The paper is removed from the thesis in DUO due to publisher restrictions. The published version is available at: https://doi.org/10.1111/j.1600-0404.2009.01250.x | |
| dc.relation.haspart | Paper III: Eide PK, Brean A: Lumbar cerebrospinal fluid pressure waves versus intracranial pressure waves in idiopathic normal pressure hydrocephalus. British Journal of Neurosurgery 20(6):407-414, 2006. The paper is removed from the thesis in DUO due to publisher restrictions. The published version is available at: https://doi.org/10.1080/02688690601047312 | |
| dc.relation.haspart | Paper IV: Brean A, Eide PK, Stubhaug A: Comparison of intracranial pressure measured simultaneously within the brain parenchyma and cerebral ventricles. Journal of Clinical Monitoring and Computing 20(6): 411-414, 2006. The paper is removed from the thesis in DUO due to publisher restrictions. The published version is available at: https://doi.org/10.1007/s10877-006-9047-7 | |
| dc.relation.haspart | Paper V: Brean A, Eide PK: Assessment of idiopathic normal pressure patients in neurological practice: The role of lumbar infusion testing for referral of patients to neurosurgery. European Journal of Neurology 15(6): 605-612, 2008. The paper is removed from the thesis in DUO due to publisher restrictions. The published version is available at: https://doi.org/10.1111/j.1468-1331.2008.02134.x | |
| dc.relation.haspart | Paper VI: Eide PK, Brean A: Cerebrospinal fluid pulse pressure amplitude during lumbar infusion in idiopathic normal pressure hydrocephalus can predict response to shunting. Cerebrospinal Fluid Research 7(5), 2010. Published under a Creative Commons Attribution License. The published version of this paper is available at: https://doi.org/10.1186/1743-8454-7-5 | |
| dc.relation.uri | https://doi.org/10.1111/j.1600-0404.2007.00982.x | |
| dc.relation.uri | https://doi.org/10.1111/j.1600-0404.2009.01250.x | |
| dc.relation.uri | https://doi.org/10.1080/02688690601047312 | |
| dc.relation.uri | https://doi.org/10.1007/s10877-006-9047-7 | |
| dc.relation.uri | https://doi.org/10.1111/j.1468-1331.2008.02134.x | |
| dc.relation.uri | https://doi.org/10.1186/1743-8454-7-5 | |
| dc.title | Idiopathic normal pressure hydrocephalus in neurological practice : A study of epidemiology and methods for selection of patients for surgery | en_US |
| dc.type | Doctoral thesis | en_US |
| dc.date.updated | 2011-08-26 | en_US |
| dc.creator.author | Brean, Are | en_US |
| dc.subject.nsi | VDP::700 | en_US |
| cristin.unitcode | 130000 | en_US |
| cristin.unitname | Medisinske fakultet | en_US |
| dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft.au=Brean, Are&rft.title=Idiopathic normal pressure hydrocephalus in neurological practice&rft.inst=University of Oslo&rft.date=2011&rft.degree=Doktoravhandling | en_US |
| dc.identifier.urn | URN:NBN:no-27869 | en_US |
| dc.type.document | Doktoravhandling | en_US |
| dc.identifier.duo | 114655 | en_US |
| dc.contributor.supervisor | Per Kristian Eide | en_US |
| dc.identifier.bibsys | 114146004 | en_US |
| dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/27953/3/dravhandling-brean.pdf | |