Browsing Det odontologiske fakultet by Author "Olsen, Ingar"
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Singhrao, Sim K; Olsen, Ingar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)Our research into Alzheimer’s disease (AD) focuses on the oral cavity and the brain, from which key evaluations of prospective and retrospective population-based data have shown that chronic periodontal disease existing ...
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Olsen, Ingar; Nichols, Frank C (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)The keystone periodontal pathogen Porphyromonas gingivalis produces phosphorylated dihydroceramide lipids (sphingolipids) such as phosphoethanolamine dihydroceramide (PE DHC) and phosphoglycerol dihydroceramide (PG DHC) ...
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Singhrao, Sim K; Olsen, Ingar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)Chronic periodontitis of 10 years’ duration is reported to become a twofold risk factor for the development of Alzheimer’s disease (AD). Periodontitis is modifiable, and this fits with the current action plan for preventing ...
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Olsen, Ingar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)The objective of the present review is to discuss if the yeast vacuole can be used as a target for attenuation of Candida albicans virulence. Literature searches were made electronically using predetermined inclusion ...
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Armingohar, Zahra; Jørgensen, Jørgen J.; Kristoffersen, Anne Karin; Abesha-Belay, Emnet; Olsen, Ingar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)Background: Several studies have reported an association between chronic periodontitis (CP) and cardiovascular diseases. Detection of periodontopathogens, including red complex bacteria (RCB), in vascular lesions has ...
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Olsen, Ingar; Yamazaki, Kazuhisa (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)Oral bacteria spreading through the body have been associated with a number of systemic diseases. The gut is no exception. Studies in animals and man have indicated that oral bacteria can translocate to the gut and change ...
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Olsen, Ingar; Singhrao, Sim K (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)Alzheimer’s disease (AD) is a scourge of longevity that will drain enormous resources from public health budgets in the future. Currently, there is no diagnostic biomarker and/or treatment for this most common form of ...
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Can Porphyromonas gingivalis Contribute to Alzheimer’s Disease Already at the Stage of Gingivitis? Olsen, Ingar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)Alzheimer’s disease (AD) has been associated with periodontitis, which starts as gingivitis. Similar to periodontitis, gingivitis bacteria, bacterial products, and inflammatory mediators can travel to the brain via the ...
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Olsen, Ingar; Singhrao, Sim K; Potempa, Jan (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)Periodontitis, rheumatoid arthritis (RA), atherosclerosis (AS), and Alzheimer’s disease (AD) are examples of complex human diseases with chronic inflammatory components in their etiologies. The initial trigger of inflammation ...
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Olsen, Ingar (Journal article / Tidsskriftartikkel / PublishedVersion, 2015)
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Olsen, Ingar (Journal article / Tidsskriftartikkel / PublishedVersion, 2016)
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Chen, Tsute; Siddiqui, Huma; Olsen, Ingar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)At the current time, genome sequences of a total of 13 Porphyromonas gingivalis strains are available, including five completed genomes (strains ATCC 33277, HG66, TDC60, JCVISC001, and W83) and eight high-coverage draft ...
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Andersen, Kari-Mette; Kristoffersen, Anne Karin; Ingebretsen, André; Vikholt, Katharina Johnsen; Ørtengren, Ulf Thore; Olsen, Ingar; Enersen, Morten; Gaustad, Peter (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)Background: Increasing numbers of immunocompromised patients have resulted in greater incidence of invasive fungal infections with high mortality. Candida albicans infections dominate, but during the last decade, Candida ...
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Søraas, Arne Vasli Lund; Olsen, Ingar; Sundsfjord, Arnfinn; Handal, Trude; Bjørang, Ola; Jenum, Pål (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)Background: The prevalence of infections caused by Cefotaximase-Munich (CTX-M)-type extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) has rapidly increased during the past 15 years. Enterobacteriaceae ...
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Olsen, Ingar; Chen, Tsute; Tribble, Gena D (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)Porphyromonas gingivalis is considered a keystone pathogen in adult periodontitis but has also been associated with systemic diseases. It has a myriad of virulence factors that differ between strains. Genetic exchange and ...
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Siddiqui, Huma; Yoder-Himes, Deborah Ruth; Mizgalska, Danuta; Nguyen, Ky-Anh; Potempa, Jan; Olsen, Ingar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)Porphyromonas gingivalis is considered a major etiologic agent in adult periodontitis. Gingipains are among its most important virulence factors, but their release is unique in strain HG66. We present the genome sequence ...
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Siddiqui, Huma; Eribe Ribs, Emenike K; Singhrao, Sim K; Olsen, Ingar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)The sporadic form of Alzheimer’s disease (AD) is the most common form of dementia characterized microscopically by the presence of amyloid-beta (Aβ) plaques and tau neurofibrillary tangles with the clinical presentation ...
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Olsen, Ingar; Singhrao, Sim K (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)Lipopolysaccharide (LPS) of Porphyromonas gingivalis exists in at least two known forms, O-LPS and A-LPS. A-LPS shows heterogeneity in which two isoforms designated LPS1,435/1,449 and LPS1,690 appear responsible for ...
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Chen, Tsute; Siddiqui, Huma; Olsen, Ingar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)Currently, genome sequences of a total of 19 Porphyromonas gingivalis strains are available, including eight completed genomes (strains W83, ATCC 33277, TDC60, HG66, A7436, AJW4, 381, and A7A1-28) and 11 high-coverage draft ...
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Olsen, Ingar; Singhrao, Sim K. (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)Inflammasomes are responsible for the maturation of pro-inflammatory cytokines such as interleukin (IL)-1β, IL-18, and IL-33 and activation of inflammatory cell death, pyroptosis. They assemble in response to cellular ...