Browsing Det medisinske fakultet by Author "MacRae, James I."

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  • Protein kinase C-β dictates B cell fate by regulating mitochondrial remodeling, metabolic reprogramming, and heme biosynthesis 
    Tsui, Carlson; Martínez-Martín, Nuria; Gaya, Mauro; Maldonado, Paula; Llorian, Miriam; Legrave, Nathalie M.; Rossi, Merja; MacRae, James I.; Cameron, Angus J.; Parker, Peter J.; Leitges, Michael; Bruckbauer, Andreas; Batista, Facundo D. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    PKCβ-null (Prkcb−/−) mice are severely immunodeficient. Here we show that mice whose B cells lack PKCβ failed to form germinal centers and plasma cells, which undermined affinity maturation and antibody production in ...