Browsing Det medisinske fakultet by Author "Gabrielsen, Odd Stokke"

Now showing items 1-4 of 4

  • Chromatin occupancy and target genes of the haematopoietic master transcription factor MYB 
    Lemma, Roza Berhanu; Ledsaak, Marit; Fuglerud, Bettina Maria; Sandve, Geir Kjetil; Eskeland, Ragnhild; Gabrielsen, Odd Stokke (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    The transcription factor MYB is a master regulator in haematopoietic progenitor cells and a pioneer factor affecting differentiation and proliferation of these cells. Leukaemic transformation may be promoted by high MYB ...
  • LXRα Regulates ChREBPα Transactivity in a Target Gene-Specific Manner through an Agonist-Modulated LBD-LID Interaction 
    Fan, Qiong; Nørgaard, Rikke Christine; Grytten, Ivar; Ness, Cecilie Maria; Lucas, Christin; Vekterud, Kristin; Soedling, Helen; Matthews, Jason; Lemma, Roza Berhanu; Gabrielsen, Odd Stokke; Bindesbøll, Christian; Ulven, Stine Marie; Nebb, Hilde Irene; Grønning-Wang, Line Mariann; Sæther, Thomas (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    The cholesterol-sensing nuclear receptor liver X receptor (LXR) and the glucose-sensing transcription factor carbohydrate responsive element-binding protein (ChREBP) are central players in regulating glucose and lipid ...
  • MYB insufficiency disrupts proteostasis in hematopoietic stem cells, leading to age-related neoplasia 
    Clarke, Mary L.; Lemma, Roza Berhanu; Walton, David Scott; Volpe, Giacomo; Noyvert, Boris; Gabrielsen, Odd Stokke; Frampton, Jon (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    MYB plays a key role in gene regulation throughout the hematopoietic hierarchy and is critical for the maintenance of normal hematopoietic stem cells (HSC). Acquired genetic dysregulation of MYB is involved in the etiology ...
  • MYB regulates the SUMO protease SENP1 and its novel interaction partner UXT, modulating MYB target genes and the SUMO landscape 
    Lemma, Roza Berhanu; Ledsaak, Marit; Fuglerud, Bettina Maria; Rodríguez-Castañeda, Fernando; Eskeland, Ragnhild; Gabrielsen, Odd Stokke (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    SUMOylation is a post-translational modification frequently found on nuclear proteins, including transcription factors (TFs) and coactivators. By controlling the activity of several TFs, SUMOylation may have far-reaching ...