Browsing Det medisinske fakultet by Title

Now showing items 77-96 of 601

  • CDK9 Inhibition Induces a Metabolic Switch that Renders Prostate Cancer Cells Dependent on Fatty Acid Oxidation 
    Itkonen, Harri; Poulose, Ninu; Walker, Suzanne; Mills, Ian Geoffrey (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Cyclin-dependent kinase 9 (CDK9), a key regulator of RNA-polymerase II, is a candidate drug target for cancers driven by transcriptional deregulation. Here we report a multi-omics-profiling of prostate cancer cell responses ...
  • Cell death induced by the ER stressor thapsigargin involves death receptor 5, a non-autophagic function of MAP1LC3B, and distinct contributions from unfolded protein response components 
    Lindner, Paula; Christensen, Søren B; Nissen, Poul; Møller, Jesper V; Engedal, Nikolai (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Background Cell death triggered by unmitigated endoplasmic reticulum (ER) stress plays an important role in physiology and disease, but the death-inducing signaling mechanisms are incompletely understood. ...
  • A Cell-Based High-Throughput Assay for Gap Junction Communication Suitable for Assessing Connexin 43-Ezrin Interaction Disruptors Using IncuCyte ZOOM 
    Dukic, Aleksandra; McClymont, David; Tasken, Kjetil (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
    Connexin 43 (Cx43), the predominant gap junction (GJ) protein, directly interacts with the A-kinase-anchoring protein (AKAP) Ezrin in human cytotrophoblasts and a rat liver epithelial cells (IAR20). The Cx43-Ezrin–protein ...
  • A cellular automaton for modeling non-trivial biomembrane ruptures 
    Gupta, Abhay; Gözen, Irep; Taylor, Michael (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
    A novel cellular automaton (CA) for simulating biological membrane rupture is proposed. Constructed via simple rules governing deformation, tension, and fracture, the CA incorporates ideas from standard percolation models ...
  • CENP-A and CENP-B collaborate to create an open centromeric chromatin state 
    Nagpal, Harsh; Ali Ahmad, Ahmad; Hirano, Yasuhiro; Cai, Wei; Halic, Mario; Fukagawa, Tatsuo; Sekulic, Nikolina; Fierz, Beat (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Centromeres are epigenetically defined via the presence of the histone H3 variant CENP-A. Contacting CENP-A nucleosomes, the constitutive centromere associated network (CCAN) and the kinetochore assemble, connecting the ...
  • CENP-A nucleosome-a chromatin-embedded pedestal for the centromere: lessons learned from structural biology 
    Ali-Ahmad, Ahmad; Sekulic, Nikolina (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Abstract The centromere is a chromosome locus that directs equal segregation of chromosomes during cell division. A nucleosome containing the histone H3 variant CENP-A epigenetically defines the centromere. Here, ...
  • CENP‐C unwraps the human CENP‐A nucleosome through the H2A C‐terminal tail 
    Ali Ahmad, Ahmad; Bilokapic, Silvija; Schafer, Ingmar B; Halic, Mario; Sekulic, Nikolina (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Centromeres are defined epigenetically by nucleosomes containing the histone H3 variant CENP ‐A, upon which the constitutive centromere‐associated network of proteins (CCAN ) is built. CENP ‐C is considered to be a central ...
  • Cerebrospinal fluid markers for synaptic function and Alzheimer type changes in late life depression 
    Siafarikas, Nikias Ioannis; Kirsebom, Bjørn-Eivind; Srivastava, Deepak P; Eriksson, Cecilia Magdalena; Auning, Eirik; Hessen, Erik; Selbæk, Geir; Blennow, Kaj; Aarsland, Dag; Fladby, Tormod (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Abstract To explore markers for synaptic function and Alzheimer disease (AD) pathology in late life depression (LLD), predementia AD and normal controls (NC). A cross-sectional study to compare cerebrospinal fluid (CSF) ...
  • Changes of 5-hydroxymethylcytosine distribution during myeloid and lymphoid differentiation of CD34+ cells 
    Tekpli, Xavier; Urbanucci, Alfonso; Hashim, Adnan; Vågbø, Cathrine B; Lyle, Robert; Kringen, Marianne K; Staff, Anne C; Dybedal, Ingunn; Mills, Ian G; Klungland, Arne; Staerk, Judith (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
    Background Hematopoietic stem cell renewal and differentiation are regulated through epigenetic processes. The conversion of 5-methylcytosine into 5-hydroxymethylcytosine (5hmC) by ten-eleven-translocation ...
  • Chaperone-assisted thermostability engineering of a soluble T cell receptor using phage display 
    Gunnarsen, Kristin Støen; Kristinsson, Solveig Gunn; Justesen, Sune; Frigstad, Terje; Buus, Søren; Bogen, Bjarne; Sandlie, Inger; Løset, Geir Åge (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
    We here report a novel phage display selection strategy enabling fast and easy selection of thermostabilized proteins. The approach is illustrated with stabilization of an aggregation-prone soluble single chain T cell ...
  • Characterization of degradation and heterozygote balance by simulation of the forensic DNA analysis process 
    Hansson, Nils Oskar Gunnar; Egeland, Thore; Gill, Peter (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
    Simulation experiments were used to show the impact of varying extraction efficiency, aliquot proportion, and PCR efficiency on the heterozygote balance of a range of diploid and haploid cells. Reducing either parameters ...
  • Characterization of TCDD-inducible poly-ADP-ribose polymerase (TIPARP/ARTD14) catalytic activity 
    Gomez, Alvin; Bindesbøll, Christian; Venkata, Satheesh; Grimaldi, Giulia; Hutin, David; MacPherson, Laura; Ahmed, Shaimaa; Tamblyn, Laura; Cho, Tiffany; Nebb, Hilde Irene; Moen, Anders; Anonsen, Jan Haug; Grant, Denis M; Matthews, Jason (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Here, we report the biochemical characterization of the mono-ADP-ribosyltransferase 2,3,7,8-tetrachlorodibenzo-p-dioxin poly-ADP-ribose polymerase (TIPARP/ARTD14/PARP7), which is known to repress aryl hydrocarbon receptor ...
  • Characterization of the Enzymatic Activity of the Serine Protease Domain of Factor VII Activating Protease (FSAP) 
    Nielsen, Nis Valentin; Roedel, Elfie; Manna, Dipankar; Etscheid, Michael; Morth, Jens Preben; Kanse, Sandip (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Factor VII (FVII) activating protease (FSAP) is a circulating serine protease. Human genetic studies, based on the Marburg I (MI) (Gly221Glu, chymotrypsin numbering system) polymorphism, implicate FSAP in the pathogenesis ...
  • Characterization of the human RFX transcription factor family by regulatory and target gene analysis 
    Sugiaman-Trapman, Debora; Vitezic, Morana; Jouhilahti, Eeva-Mari; Mathelier, Anthony; Lauter, Gilbert; Misra, Sougat; Daub, Carsten O; Kere, Juha; Swoboda, Peter (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Background Evolutionarily conserved RFX transcription factors (TFs) regulate their target genes through a DNA sequence motif called the X-box. Thereby they regulate cellular specialization and terminal ...
  • Childhood obesity is a High-risk factor for hypertriglyceridemia: A case-control study in Vietnam 
    Hong Hanh, Nguyen Thi; Tuyet, Le Thi; Anh Dao, Duong Thi; Tao, Yang; Chu, Dinh Toi (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
    Objectives: To investigate the relationship between dyslipidemia and obesity status among Viet-namese adolescents. Methods: In this case-control study, 282 adolescents (6–11 years), including 88 obese cases and 194 ...
  • Childhood seizures after prenatal exposure to maternal influenza infection: A population-based cohort study from Norway, Australia and Canada 
    Oakley, Laura L; Regan, Annette K.; Fell, Deshayne B.; Spruin, Sarah; Bakken, Inger Johanne Landsjøåsen; Kwong, Jeffrey C; Pereira, Gavin; Nassar, Natasha; Aaberg, Kari Modalsli; Wilcox, Allen J.; Håberg, Siri Eldevik (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2021)
    Objective To assess whether clinical and/or laboratory-confirmed diagnosis of maternal influenza during pregnancy increases the risk of seizures in early childhood. Design Analysis of prospectively collected registry data ...
  • Children With Developmental Language Disorder Have Lower Quality of Life Than Children With Typical Development and Children With Cochlear Implants 
    Haukedal, Christiane; Wie, Ona Bø; Schauber, Stefan; Torkildsen, Janne von Koss (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2023)
    Purpose: The purpose of this study was to examine quality of life (QOL) and its relation to language skills in children with developmental language disorder (DLD). This was examined by comparing QOL to a control group ...
  • Children’s knowledge of single- and multiple-letter grapheme-phoneme correspondences: An exploratory study 
    Larsen, Linda Paarup Neigaard; Schauber, Stefan Kilian; Kohen, Saskia; Nickels, Lyndsey; McArthur, Genevieve (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    In this study, we examined Australian children’s knowledge of single- and multiple-letter grapheme-phoneme correspondences (GPCs), and the influence of five different factors – GPC complexity, phoneme status, the child’s ...
  • Chromatin occupancy and target genes of the haematopoietic master transcription factor MYB 
    Lemma, Roza Berhanu; Ledsaak, Marit; Fuglerud, Bettina Maria; Sandve, Geir Kjetil; Eskeland, Ragnhild; Gabrielsen, Odd Stokke (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    The transcription factor MYB is a master regulator in haematopoietic progenitor cells and a pioneer factor affecting differentiation and proliferation of these cells. Leukaemic transformation may be promoted by high MYB ...
  • Chromatin organisation and cancer prognosis: a pan-cancer study 
    Kleppe, Andreas; Albregtsen, Fritz; Vlatkovic, Ljiljana; Pradhan, Manohar; Nielsen, Birgitte; Hveem, Tarjei Sveinsgjerd; Askautrud, Hanne Arenberg; Kristensen, Gunnar S Balle; Nesbakken, Arild; Trovik, Jone; Wæhre, Haakon; Tomlinson, Ian; Shepherd, Neil A.; Novelli, Marco; Kerr, David J.; Danielsen, Håvard Emil (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Background Chromatin organisation affects gene expression and regional mutation frequencies and contributes to carcinogenesis. Aberrant organisation of DNA has been correlated with cancer prognosis in analyses of the ...