Browsing Det medisinske fakultet by Title

Now showing items 37-56 of 601

  • The androgen receptor controls expression of the cancerassociated sTn antigen and cell adhesion through induction of ST6GalNAc1 in prostate cancer 
    Munkley, Jennifer; Oltean, Sebastian; Vodak, Daniel; Wilson, Brian T.; Livermore, Karen E.; Zhou, Yan; Star, Eleanor; Floros, Vasileios I.; Johannessen, Bjarne; Knight, Bridget; McCullagh, Paul; McGrath, John; Crundwell, Malcolm; Skotheim, Rolf Inge; Robson, Craig N.; Leung, Hing Y.; Harries, Lorna W.; Rajan, Prabhakar; Mills, Ian Geoffrey; Elliott, David J. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    Patterns of glycosylation are important in cancer, but the molecular mechanisms that drive changes are often poorly understood. The androgen receptor drives prostate cancer (PCa) development and progression to lethal ...
  • Androgen receptor deregulation drives bromodomain-mediated chromatin alterations in prostate cancer 
    Urbanucci, Alfonso; Barfeld, Stefan Jörg; Kytölä, Ville; Itkonen, Harri; Coleman, Ilsa M.; Vodák, Daniel; Sjöblom, Liisa; Sheng, Xia; Minner, Sarah; Burdelski, Christoph; Kivinummi, Kati K.; Kohvakka, Annika; Kregel, Steven; Takhar, Mandeep; Alshalalfa, Mohammed; Davicioni, Elai; Erho, Nicholas; Lloyd, Paul; Karnes, R. Jeffrey; Ross, Ashley E.; Schaeffer, Edward M.; Vander Griend, Donald J; Knapp, Stefan; Corey, Eva; Feng, Felix Y.; Nelson, Peter S.; Saatcioglu, Fahri; Knudsen, Karen E.; Tammela, Teuvo L.J.; Sauter, Guido; Schlomm, Thorsten; Nykter, Matti; Visakorpi, Tapio; Mills, Ian Geoffrey (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Global changes in chromatin accessibility may drive cancer progression by reprogramming transcription factor (TF) binding. In addition, histone acetylation readers such as bromodomain-containing protein 4 (BRD4) have been ...
  • Angular and linear speed cells in the parahippocampal circuits 
    Spalla, Davide; Treves, Alessandro; Boccara, Charlotte (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Abstract An essential role of the hippocampal region is to integrate information to compute and update representations. How this transpires is highly debated. Many theories hinge on the integration of self-motion signals ...
  • Annotated Expressed Sequence Tags (ESTs) from pre-smolt Atlantic salmon (Salmo salar) in a searchable data resource 
    Adzhubei, Alexei A; Vlasova, Anna V; Hagen-Larsen, Heidi; Ruden, Torgeir A; Laerdahl, Jon K; Høyheim, Bjørn (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
    Background To identify as many different transcripts/genes in the Atlantic salmon genome as possible, it is crucial to acquire good cDNA libraries from different tissues and developmental stages, their ...
  • Anomalous Diffusion of Extracellular Vesicles in an Extracellular Matrix for Molecular Communication 
    Rudsari, Hamid Khoshfekr; Zoofaghari, Mohammad; Damrath, Martin; Veletic, Mladen; Bergsland, Jacob; Balasingham, Ilangko (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2023)
    Anomalous diffusion of extracellular vesicles (EVs) occurs because of the natural stiffness and stress relaxation of the extracellular matrix (ECM). This phenomenon has not been considered so far in attempts of computational ...
  • Anti-carcinoembryonic Antigen Single-chain Variable Fragment Antibody Variants Bind Mouse and Human Neonatal Fc Receptor with Different Affinities That Reveal Distinct Cross-species Differences in Serum Half-life 
    Andersen, Jan Terje; Foss, Stian; Kenanova, Vania E; Olafsen, Tove; Leikfoss, Ingvild Sørum; Roopenian, Derry C; Wu, Anna M; Sandlie, Inger (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
    Serum half-life of IgG is controlled by the neonatal Fc receptor (FcRn) that interacts with the IgG Fc region and may be increased or decreased as a function of altered FcRn binding. Preclinical evaluations of modified ...
  • Antibodies against Neisseria meningitidis serogroups A, C, W and Y in serum and saliva of Norwegian adolescents 
    Watle, Sara Viksmoen; Børud, Bente; Laake, Ida; Baranowska-Hustad, Marta Natalia; Bryant-Bratlie, Diane Lynn; Bekkevold, Terese; Caugant, Dominique A.; Tunheim, Gro; Næss, Lisbeth Meyer (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Introduction The incidence of invasive meningococcal disease (IMD) among Norwegian 16–19-year-olds was 1–7/100,000 in the decade before the COVID-19 pandemic, with serogroup Y (MenY) dominance. In contrast to many other ...
  • Antibody-antigen kinetics constrain intracellular humoral immunity 
    Bottermann, Maria; Lode, Heidrun Elisabeth; Watkinson, Ruth E; Foss, Stian; Sandlie, Inger; Andersen, Jan Terje; James, Leo C. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
    During infection with non-enveloped viruses, antibodies stimulate immunity from inside cells by activating the cytosolic Fc receptor TRIM21. This intracellular humoral response relies on opsonized viral particles reaching ...
  • Antibody-mediated delivery of T-cell epitopes to antigen-presenting cells induce strong CD4 and CD8 T-cell responses 
    Høydahl, Lene; Frigstad, Terje; Rasmussen, Ingunn B; Øynebråten, Inger; Schjetne, Karoline W; Andersen, Jan Terje; Michaelsen, Terje Einar; Lunde, Elin; Bogen, Bjarne; Sandlie, Inger (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Targeted delivery of antigen to antigen-presenting cells (APCs) enhances antigen presentation and thus, is a potent strategy for making more efficacious vaccines. This can be achieved by use of antibodies with specificity ...
  • Anticonvulsant Activity of Pterostilbene in Zebrafish and Mouse Acute Seizure Tests 
    Nieoczym, Dorota; Socala, Katarzyna; Gawel, Kamila; Esguerra, Camila Vicencio; Wyska, Elzbieta; Wlaz, Piotr (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Pterostilbene (PTE), a natural dimethylated analog of resveratrol, possesses numerous health-beneficial properties. The ability of PTE to cross the blood–brain barrier raised the possibility that this compound may modulate ...
  • Are infants exposed to antimicrobials during the first 3 months of life at increased risk of recurrent use? An explorative data-linkage study 
    Thaulow, Christian Magnus; Harthug, Stig; Nilsen, Roy Miodini; Eriksen, Beate Horsberg; Wathne, Jannicke Slettli; Berild, Dag; Blix, Hege Salvesen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Abstract Objectives To investigate whether infants exposed to antimicrobials in hospital during the first 3 months of life had an increased risk of ambulatory antimicrobial use during the ...
  • Artificial intelligence can guide antibiotic choice in recurrent UTIs and become an important aid to improve antimicrobial stewardship 
    Tommaso, Cai; Anceschi, Umberto; Prata, Francesco; Collini, Lucia; Brugnolli, Anna; Migno, Serena; Rizzo, Michele; Liguori, Giovanni; Gallelli, Luca; Wagenlehner, Florian M. E.; Johansen, Truls Erik Bjerklund; Montanari, Luca; Palmieri, Alessandro; Tascini, Carlo (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Background: A correct approach to recurrent urinary tract infections (rUTIs) is an important pillar of antimicrobial stewardship. We aim to define an Artificial Neural Network (ANN) for predicting the clinical efficacy of ...
  • Assessment of cardiac structure and function in a murine model of temporal lobe epilepsy 
    Gonzalez, Alba; Nome, Cecilie; Bendiksen, Bård Andre; Sjaastad, Ivar; Zhang, Lili; Aleksandersen, Mona; Taubøll, Erik; Aurlien, Dag; Heuser, Kjell (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Sudden unexpected death in epilepsy (SUDEP) is a significant cause of premature seizure-related death. An association between SUDEP and cardiac remodeling has been suggested. However, whether SUDEP is a direct consequence ...
  • Association between long-term neuro-toxicities in testicular cancer survivors and polymorphisms in glutathione-s-transferase-P1 and -M1, a retrospective cross sectional study 
    Oldenburg, Jan; Kraggerud, Sigrid M; Brydøy, Marianne; Cvancarova, Milada; Lothe, Ragnhild A; Fossa, Sophie D (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
    Background To assess the impact of polymorphisms in Glutathione S-transferase (GST) -P1, -M1, and -T1 on self-reported chemotherapy-induced long-term toxicities in testicular cancer survivors (TCSs). ...
  • Association of vaccination, international travel, public health and social measures with lineage dynamics of SARS-CoV-2 
    Yang, Lingyue; Wang, Zengmiao; Wang, Lin; Vrancken, Bram; Wang, Ruixue; Wei, Yuanlong; Rader, Benjamin; Wu, Chieh-Hsi; Chen, Yuyang; Wu, Peiyi; Li, Bingying; Lin, Qiushi; Dong, Lu; Cui, Yujun; Shi, Mang; Brownstein, John S.; Stenseth, Nils Christian; Yang, Ruifu; Tian, Huaiyu (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Continually emerging SARS-CoV-2 variants of concern that can evade immune defenses are driving recurrent epidemic waves of COVID-19 globally. However, the impact of measures to contain the virus and their effect on lineage ...
  • Associations of pain sensitisation with tender and painful joint counts in people with hand osteoarthritis: results from the Nor-Hand study 
    Gløersen, Marthe; Pettersen, Pernille Steen; Neogi, Tuhina; Slatkowsky-Christensen, Barbara; Kvien, Tore Kristian; Magnusson, Karin; Hammer, Hilde Berner; Bos-Haugen, Ida Kristin (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Objective: To examine associations of pain sensitisation with tender and painful joint counts and presence of widespread pain in people with hand osteoarthritis (OA). Methods: Pressure pain thresholds (PPT) at a painful ...
  • AtOM, an ontology model to standardize use of brain atlases in tools, workflows, and data infrastructures 
    Kleven, Heidi; Gillespie, Thomas; Zehl, Lyuba; Dickscheid, Timo; Bjaalie, Jan G.; Maryann E., Martone; Leergaard, Trygve B. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Brain atlases are important reference resources for accurate anatomical description of neuroscience data. Open access, three-dimensional atlases serve as spatial frameworks for integrating experimental data and defining ...
  • ATPase activity of DFCP1 controls selective autophagy 
    Nahse-Kumpf, Viola; Raiborg, Camilla; Tan, Kia Wee; Mørk, Sissel; Torgersen, Maria Lyngaas; Wenzel, Eva; Nager Grifo, Mireia; Salo, Veijo T.; Johansen, Terje; Ikonen, Elina; Schink, Kay Oliver; Stenmark, Harald Alfred (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Abstract Cellular homeostasis is governed by removal of damaged organelles and protein aggregates by selective autophagy mediated by cargo adaptors such as p62/SQSTM1. Autophagosomes can assemble in specialized cup-shaped ...
  • Authorship: attitudes and practice among Norwegian researchers 
    Nylenna, Magne; Fagerbakk, Frode; Kierulf, Peter (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
    Background Attitudes to, and practices of, scientific authorship vary. We have studied this variation among researchers in a university hospital and medical school in Norway. ...
  • Autologous bone marrow Th cells can support multiple myeloma cell proliferation in vitro and in xenografted mice 
    Wang, Dong; Fløisand, Yngvar; Myklebust, Camilla Victoria; Bürgler, Simone; Ribes, Anna Maria Parente; Hofgaard, Peter Olaf; Bogen, Bjarne; Tasken, Kjetil; Tjønnfjord, Geir Erland; Schjesvold, Fredrik Hellem; Dalgaard, Jakob; Tveita, Anders; Munthe, Ludvig Andre (Journal article / Tidsskriftartikkel / SubmittedVersion, 2017)
    Multiple myeloma (MM) is a plasma cell malignancy where MM cell growth is supported by the bone marrow (BM) microenvironment with poorly defined cellular and molecular mechanisms. MM cells express CD40, a receptor known ...