Browsing Det medisinske fakultet by Issue Date
Now showing items 21-40 of 601
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)Background Efficient expression systems exist for antibody (Ab) molecules, which allow for characterization of large numbers of individual Ab variants. In contrast, such expression systems have been lacking ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)Background Despite comprehensive investigation, the Escherichia coli SOS response system is not yet fully understood. We have applied custom designed whole genome tiling arrays to measure UV invoked transcriptional changes ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)Activation of oxidative stress-responses and downregulation of insulin-like signaling (ILS) is seen in Nucleotide Excision Repair (NER) deficient segmental progeroid mice. Evidence suggests that this is a survival response ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)Background The adenomatous polyposis coli (APC) protein is part of the destruction complex controlling proteosomal degradation of β-catenin and limiting its nuclear translocation, which is thought to play ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)Background Alcohol use is increasing among women in Africa, and comparable information about women's current alcohol use is needed to inform national and international health policies relevant to the entire ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)The study of proteins and the interactions between them, known as Protein-Protein Interactions (PPI), is extremely important in interpreting all biological cellular functions. In this article, a new web tool called ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)Background Colorectal cancer (CRC) is a heterogeneous disease that, on the molecular level, can be characterized by inherent genomic instabilities; chromosome instability and microsatellite instability. In ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)Background The iRefIndex consolidates protein interaction data from ten databases in a rigorous manner using sequence-based hash keys. Working with consolidated interaction data comes with distinct challenges: ...
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MDM2 antagonist Nutlin-3a potentiates antitumour activity of cytotoxic drugs in sarcoma cell lines (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)Background Frequent failure and severe side effects of current sarcoma therapy warrants new therapeutic approaches. The small-molecule MDM2 antagonist Nutlin-3a activates the p53 pathway and efficiently ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)Background The present study was performed to compare blood product consumption and clinical results in consecutive, unselected trauma patients during the first 6 months of year 2002, 2004 and 2007. ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)Förster Resonance Energy Transfer , abbreviated FRET , is a fluorescence phenomenon, which can be used to study and map co-localizations and dynamics of co-localizations at nanometer precision on a light microscope. FRET ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)Dendrodendritic electrical signaling via gap junctions is now an accepted feature of neuronal communication in mammalian brain, whereas axodendritic and axosomatic gap junctions have rarely been described. We present ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)The competence-stimulating peptide (CSP) and the sigX-inducing peptide (XIP) are known to induce Streptococcus mutans competence for genetic transformation. For both pheromones, direct identification of the native peptides ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)Glutamine synthetase (GS) is ubiquitously expressed in mammalian organisms and is a key enzyme in nitrogen metabolism. It is the only known enzyme capable of synthesising glutamine, an amino acid with many critical roles ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)A positive inotropic responsiveness to serotonin, mediated by 5-HT4 and 5-HT2A receptors, appears in the ventricle of rats with post-infarction congestive heart failure (HF) and pressure overload-induced hypertrophy. A ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)Ca2+-ATPases are members of a large family of membrane proteins that maintain the selective movement of cations across biological membranes. A putative Listeria monocytogenes Ca2+-ATPase (Lmo0818) was crystallized in an ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)The mechanisms of successful epigenetic reprogramming in cancer are not well characterized as they involve coordinated removal of repressive marks and deposition of activating marks by a large number of histone and DNA ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)Background There is a huge effort in developing ligand-mediated targeting of nanoparticles to diseased cells and tissue. The plant toxin ricin has been shown to enter cells by utilizing both dynamin-dependent ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)Serum half-life of IgG is controlled by the neonatal Fc receptor (FcRn) that interacts with the IgG Fc region and may be increased or decreased as a function of altered FcRn binding. Preclinical evaluations of modified ...