Browsing Molekylærbiologi by Title
Now showing items 14-33 of 146
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Cancer immunosurveillance mediated by CD4+ T cells - focus on dendritic cells and interleukin-1 secretionRestricted Access (Master thesis / Masteroppgave, 2011)Tumor-specific CD4+ T cells coordinate the adaptive immune response against cancer. Dendritic cells (DCs) are professional antigen presenting cells that are believed to be important for the initial activation of naïve ...
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(Master thesis / Masteroppgave, 2011)Cells that grow in a restricted area will eventually become confluent. At that point normal cells will stop dividing, while cancer cells, with their invasive properties, will continue dividing. It has been known for quite ...
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Cellular and sub-cellular localization of different N-methyl-D-aspartate receptor subunits in the hippocampal formation of mature and aged mice lacking the Neil3 geneRestricted Access (Master thesis / Masteroppgave, 2009)High levels of oxidative stress are a common aspect of most neurodegenerative disorders. Oxidative stress in the brain causes DNA lesions that are mainly repaired by the base excision repair (BER) pathway. The BER pathway ...
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(Master thesis / Masteroppgave, 2011)Autophagy is an important growth regulatory process in eukaryotic cells. Dysfunctional autophagy can cause tumorigenesis and neurodegenerative diseases due to accumulation of defective cellular substructures and protein ...
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(Master thesis / Masteroppgave, 2009)Our group has shown that ultraviolet (UV) irradiation of fission yeast cells in G1 phase induces a delayed entry into S phase. More recently, we found that the cell cycle delay is accompanied by a general depression of ...
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(Master thesis / Masteroppgave, 2012)Paratuberculosis is a chronic enteric disease that affects ruminants. It is caused by Mycobacterium avium subsp. paratuberculosis (MAP) an obligated intracellular acid-fast bacilli that usually infect macrophages in the ...
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Characterisation of the fish pathogen Francisella in cells and zebrafish : Developing an assay for testing the delivery of drugs and vaccines using the nanoparticle systemRestricted Access (Master thesis / Masteroppgave, 2011)
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(Master thesis / Masteroppgave, 2008)Mammalian AlkB homologues (ABH) contain a 2-oxoglutarate and iron dependent dioxygenase domain, placing these proteins in the 2OG/Fe2+ dependent dioxygenase superfamily. The mammalian ABH2 and ABH3 proteins are oxidative ...
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(Master thesis / Masteroppgave, 2011)Phage display has been instrumental in discovery of novel binding peptides and folded domains for the past two decades, arguably with most success in the field of drug discovery. Despite being a mature and dominating ...
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(Master thesis / Masteroppgave, 2010)The human 5-HT7 serotonin receptor is a G-protein-coupled receptor that activates adenylyl cyclase constitutively and upon agonist-activation. In previous studies, some inverse agonists induce both homo- and heterologous ...
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(Master thesis / Masteroppgave, 2011)Gene therapy strategies have been intensively studied for over 20 years. However, there are yet no gene therapy protocols in conventional use. In this project, a gene delivery protocol was optimized for the transient ...
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(Master thesis / Masteroppgave, 2007)Prostate cancer is the most common non-skin cancer and the third leading cause of cancer death in men in developed countries. No effective cure has yet been found to treat the hormone refractory state of PCa. In addition ...
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Characterization of LSAMP, a novel candidate tumor suppressor gene in osteosarcomasRestricted Access (Master thesis / Masteroppgave, 2011)Osteosarcomas are the most common primary malignant tumors of bone. They are highly aggressive with poor prognosis, and display complex genomic aberrations. Previously, our group has identified a frequently deleted region ...
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(Master thesis / Masteroppgave, 2012)Proteins are subjected to various post-translational modifications (PTMs) that affect their activity, interaction and localization. Methylation is one such PTM that is well known to play a regulatory role in heterochromatin ...
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(Master thesis / Masteroppgave, 2011)
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(Master thesis / Masteroppgave, 2007)The E. coli AlkB protein reverses methylation damage from DNA and RNA by oxidative demethylation, a reaction dependent on Fe(II) and 2-oxoglutarate. Based on sequence similarity, eight human AlkB homologues, denoted hABH1-8, ...
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(Master thesis / Masteroppgave, 2008)The human genome encodes 8 homologues of the E.coli protein AlkB, hABH1-8. AlkB, hABH2, and hABH3 repair DNA and RNA by oxidative demetylation in the presence of Fe2+ and 2-oxoglutarate (2OG). The functions of the remaining ...
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A comparative analysis of Ii and MHC II expression during maturation of human monocyte derived dendritic cellsRestricted Access (Master thesis / Masteroppgave, 2007)The classical MHC II genes in humans, consist of the HLA-DR, HLA-DP and HLA-DQ allotypes, with multiple alleles of each [1]. Their gene products function to present peptides derived from internalized protein antigen to the ...
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(Master thesis / Masteroppgave, 2010)Mental retardation occurs in 2-3% of newborns in the population and can be inherited from the parents, caused by environmental influences or de novo mutations. Microscopically visible chromosome aberrations, such as trisomy ...
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(Master thesis / Masteroppgave, 2009)MicroRNAs (miRNAs) are a relatively newly discovered class of small endogenous non coding RNA molecules with important roles in cell function and cancer development. Mature miRNAs bind to complementary sequences of transcripts ...