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(Master thesis / Masteroppgave, 2005)ABSTRACT The aim of this thesis was to investigate the in vitro physiological and genetic responses of Bacillus cereus ATCC 14579 to bile, bile salts and mucin, substances which would be encountered in the gastrointestinal ...
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(Master thesis / Masteroppgave, 2011)Chlamydomonas reinhardtii is a widely used model organism to study chloroplast gene expression and photosynthetic processes. In this project we worked to identify a novel trans-acting factor that is thought to contribute ...
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(Master thesis / Masteroppgave, 2010)Thioredoxin (Trx) is a small ubiquitous protein containing two conserved cysteines that can reversibely form a redox-active disulfide bond, belonging to the Trx superfamily. Ribonucleotide reductase (RNR) was the first ...
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(Master thesis / Masteroppgave, 2006)In this study we have established a method for screening a collection of strains, from the Bacillus cereus group of bacteria, for biofilm formation, including soil isolates, strains from culture collections, reference ...
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Cancer immunosurveillance mediated by CD4+ T cells - focus on dendritic cells and interleukin-1 secretionBegrenset tilgang (Master thesis / Masteroppgave, 2011)Tumor-specific CD4+ T cells coordinate the adaptive immune response against cancer. Dendritic cells (DCs) are professional antigen presenting cells that are believed to be important for the initial activation of naïve ...
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(Master thesis / Masteroppgave, 2011)Cells that grow in a restricted area will eventually become confluent. At that point normal cells will stop dividing, while cancer cells, with their invasive properties, will continue dividing. It has been known for quite ...
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Cellular and sub-cellular localization of different N-methyl-D-aspartate receptor subunits in the hippocampal formation of mature and aged mice lacking the Neil3 geneBegrenset tilgang (Master thesis / Masteroppgave, 2009)High levels of oxidative stress are a common aspect of most neurodegenerative disorders. Oxidative stress in the brain causes DNA lesions that are mainly repaired by the base excision repair (BER) pathway. The BER pathway ...
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(Master thesis / Masteroppgave, 2011)Autophagy is an important growth regulatory process in eukaryotic cells. Dysfunctional autophagy can cause tumorigenesis and neurodegenerative diseases due to accumulation of defective cellular substructures and protein ...
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(Master thesis / Masteroppgave, 2009)Our group has shown that ultraviolet (UV) irradiation of fission yeast cells in G1 phase induces a delayed entry into S phase. More recently, we found that the cell cycle delay is accompanied by a general depression of ...
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(Master thesis / Masteroppgave, 2012)Paratuberculosis is a chronic enteric disease that affects ruminants. It is caused by Mycobacterium avium subsp. paratuberculosis (MAP) an obligated intracellular acid-fast bacilli that usually infect macrophages in the ...
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Characterisation of the fish pathogen Francisella in cells and zebrafish : Developing an assay for testing the delivery of drugs and vaccines using the nanoparticle systemBegrenset tilgang (Master thesis / Masteroppgave, 2011)
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(Master thesis / Masteroppgave, 2008)Mammalian AlkB homologues (ABH) contain a 2-oxoglutarate and iron dependent dioxygenase domain, placing these proteins in the 2OG/Fe2+ dependent dioxygenase superfamily. The mammalian ABH2 and ABH3 proteins are oxidative ...
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(Master thesis / Masteroppgave, 2011)Phage display has been instrumental in discovery of novel binding peptides and folded domains for the past two decades, arguably with most success in the field of drug discovery. Despite being a mature and dominating ...
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(Master thesis / Masteroppgave, 2010)The human 5-HT7 serotonin receptor is a G-protein-coupled receptor that activates adenylyl cyclase constitutively and upon agonist-activation. In previous studies, some inverse agonists induce both homo- and heterologous ...
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(Master thesis / Masteroppgave, 2011)Gene therapy strategies have been intensively studied for over 20 years. However, there are yet no gene therapy protocols in conventional use. In this project, a gene delivery protocol was optimized for the transient ...
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(Master thesis / Masteroppgave, 2007)Prostate cancer is the most common non-skin cancer and the third leading cause of cancer death in men in developed countries. No effective cure has yet been found to treat the hormone refractory state of PCa. In addition ...
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Characterization of LSAMP, a novel candidate tumor suppressor gene in osteosarcomasBegrenset tilgang (Master thesis / Masteroppgave, 2011)Osteosarcomas are the most common primary malignant tumors of bone. They are highly aggressive with poor prognosis, and display complex genomic aberrations. Previously, our group has identified a frequently deleted region ...
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(Master thesis / Masteroppgave, 2012)Proteins are subjected to various post-translational modifications (PTMs) that affect their activity, interaction and localization. Methylation is one such PTM that is well known to play a regulatory role in heterochromatin ...
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(Master thesis / Masteroppgave, 2011)
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(Master thesis / Masteroppgave, 2007)The E. coli AlkB protein reverses methylation damage from DNA and RNA by oxidative demethylation, a reaction dependent on Fe(II) and 2-oxoglutarate. Based on sequence similarity, eight human AlkB homologues, denoted hABH1-8, ...