Browsing Molekylærbiologi by Title
Now showing items 21-40 of 146
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(Master thesis / Masteroppgave, 2008)Mammalian AlkB homologues (ABH) contain a 2-oxoglutarate and iron dependent dioxygenase domain, placing these proteins in the 2OG/Fe2+ dependent dioxygenase superfamily. The mammalian ABH2 and ABH3 proteins are oxidative ...
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(Master thesis / Masteroppgave, 2011)Phage display has been instrumental in discovery of novel binding peptides and folded domains for the past two decades, arguably with most success in the field of drug discovery. Despite being a mature and dominating ...
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(Master thesis / Masteroppgave, 2010)The human 5-HT7 serotonin receptor is a G-protein-coupled receptor that activates adenylyl cyclase constitutively and upon agonist-activation. In previous studies, some inverse agonists induce both homo- and heterologous ...
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(Master thesis / Masteroppgave, 2011)Gene therapy strategies have been intensively studied for over 20 years. However, there are yet no gene therapy protocols in conventional use. In this project, a gene delivery protocol was optimized for the transient ...
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(Master thesis / Masteroppgave, 2007)Prostate cancer is the most common non-skin cancer and the third leading cause of cancer death in men in developed countries. No effective cure has yet been found to treat the hormone refractory state of PCa. In addition ...
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Characterization of LSAMP, a novel candidate tumor suppressor gene in osteosarcomasRestricted Access (Master thesis / Masteroppgave, 2011)Osteosarcomas are the most common primary malignant tumors of bone. They are highly aggressive with poor prognosis, and display complex genomic aberrations. Previously, our group has identified a frequently deleted region ...
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(Master thesis / Masteroppgave, 2012)Proteins are subjected to various post-translational modifications (PTMs) that affect their activity, interaction and localization. Methylation is one such PTM that is well known to play a regulatory role in heterochromatin ...
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(Master thesis / Masteroppgave, 2011)
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(Master thesis / Masteroppgave, 2007)The E. coli AlkB protein reverses methylation damage from DNA and RNA by oxidative demethylation, a reaction dependent on Fe(II) and 2-oxoglutarate. Based on sequence similarity, eight human AlkB homologues, denoted hABH1-8, ...
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(Master thesis / Masteroppgave, 2008)The human genome encodes 8 homologues of the E.coli protein AlkB, hABH1-8. AlkB, hABH2, and hABH3 repair DNA and RNA by oxidative demetylation in the presence of Fe2+ and 2-oxoglutarate (2OG). The functions of the remaining ...
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A comparative analysis of Ii and MHC II expression during maturation of human monocyte derived dendritic cellsRestricted Access (Master thesis / Masteroppgave, 2007)The classical MHC II genes in humans, consist of the HLA-DR, HLA-DP and HLA-DQ allotypes, with multiple alleles of each [1]. Their gene products function to present peptides derived from internalized protein antigen to the ...
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(Master thesis / Masteroppgave, 2010)Mental retardation occurs in 2-3% of newborns in the population and can be inherited from the parents, caused by environmental influences or de novo mutations. Microscopically visible chromosome aberrations, such as trisomy ...
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(Master thesis / Masteroppgave, 2009)MicroRNAs (miRNAs) are a relatively newly discovered class of small endogenous non coding RNA molecules with important roles in cell function and cancer development. Mature miRNAs bind to complementary sequences of transcripts ...
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(Master thesis / Masteroppgave, 2006)Autoimmune diseases are the drawback of having a potent immune defence. Type 1 diabetes and myasthenia gravis are examples of such diseases, where disease development is both complex and multifactorial. In general, both ...
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DAXX-dependent recruitment of the histone variant H3.3 to PML bodies prior to chromatin depositionRestricted Access (Master thesis / Masteroppgave, 2012)The genome is organized into chromatin domains which can be distinguished by enrichment in post-translational modifications of histones and histone variants. Since the histone code has been discovered, little is known about ...
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(Master thesis / Masteroppgave, 2007)In the 5`UTR of transcripts of the Chlamydomonas chloroplast gene rbcL secondary structures in the shape of two stem loops, one large and one small, have been identified. The large stem loop has been found to mediate folding ...
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Design of an inducible system to control SUMOylation of the transcription factor c-Myb in vivoRestricted Access (Master thesis / Masteroppgave, 2010)The transcription factor c-Myb is an important regulator involved in proliferation, differentiation, and apoptosis of hematopoietic cells. Its activity is regulated through interactions with co-repressors and co-activators. ...
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(Master thesis / Masteroppgave, 2010)
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(Master thesis / Masteroppgave, 2007)The gene rbcL in the Chlamydomonas chloroplast codes for a mRNA of about 1.6 kb including a 5`UnTranslated Region (5`UTR) of 92 bp.The beginning of the 5`UTR has two stem-loops as part of its secondary structure. A ...
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(Master thesis / Masteroppgave, 2008)Prionsykdommer er en gruppe nevrodegenerative, dødelige sykdommer som forekommer hos både dyr og mennesker, og forårsakes av en konformasjonsendring i det endogene prionproteinet (PrP). I normal hjerne og i flere andre ...