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Identification of small molecule inhibitors of the transcription factor c-Myb through structure-based drug design and EMSA analysisBegrenset tilgang (Master thesis / Masteroppgave, 2009)
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(Master thesis / Masteroppgave, 2005)The major histocompatibility (MHC) class II molecules present peptides to the T cell receptor on CD4+ lymphocytes. The diversity of the epitopes presented depends critically on the processing of the ingested antigens, and ...
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(Master thesis / Hovedoppgave, 2005)DNA polymeraser er av fundamental betydning for levende organismer, ettersom de spiller en avgjørende rolle i replikasjon og reparasjon av DNA. I de siste årene er de blitt viktige genteknologiske verktøy, og varmestabile ...
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(Master thesis / Hovedoppgave, 2007)Det humane genet WWOX har blitt identifisert av flere uavhengige forskningsgrupper i forbindelse med studier av strukturelle abnormaliteter på kromosom 16q i ulike krefttyper. Genet er lokalisert innenfor kromosom 16q23.3-24.1, ...
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(Master thesis / Masteroppgave, 2007)Sammendrag Transkripsjonsfaktorer har en viktig rolle i normale cellefunksjoner, men har også vist seg å være involvert i kreftutvikling. Transkripsjonsfaktoren c-Myb spiller en betydelig rolle i hematopoiesen hvor den ...
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(Master thesis / Masteroppgave, 2007)Newly synthesised proteins are therefore subjected to a strict control machinery in the ER lumen where different chaperones facilitate folding during and after translocation. If the folding process is incomplete, misfolded ...
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(Master thesis / Masteroppgave, 2007)Non-ribosomal peptide synthetases (NRPSs) are highly refined natural machines for the biosynthesis of secondary oligopeptides which cannot be synthesised by the ribosomal machinery. Due to the attractive biological potential ...
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The nitric oxide synthase protein system in Bacillus cereus : From gene to 3D structureBegrenset tilgang (Master thesis / Masteroppgave, 2012)
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(Master thesis / Masteroppgave, 2006)Photochemical internalisation (PCI) is a method for efficient delivery of macromolecules, like genes used in gene therapy, to the cytosol of cells. Most macromolecules enter a cell by endocytosis and are trapped in the ...
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(Master thesis / Hovedoppgave, 2004)ABSTRACT: A reporter gene was constructed consisting of the 5´ region of the C. reinhardtii rbcL gene from position –70 to +47, relative to the transcription start point, fused to the E. coli uidA(GUS) structural gene ...
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(Master thesis / Masteroppgave, 2006)Cancer is a disease resulting from an accumulation of acquired genetic mutations. The consequence is an uncontrolled growth of cells and disruption of normal control mechanisms. Complex chromosomal aberrations such as ...
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(Master thesis / Hovedoppgave, 2004)The rbcL promoter of C. reinhardtii has been reported to lack a functional -35 consensus motif common to the ó70 type promoters found in prokaryotes and many plastid promoters, while retaining a conserved ó70 like -10 ...
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(Master thesis / Hovedoppgave, 2004)Autofagi er en viktig proteindegraderingsmekanisme i eukaryote celler, da den er hovedmekanismen for nedbrytning av cytosoliske proteiner og organeller når tilgangen på næringsstoffer er begrenset. I tillegg er autofagi ...
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(Master thesis / Masteroppgave, 2005)Abstract Nuclear receptors that work as heterodimers with RXR control several aspects of lipid metabolism. One such nuclear receptor, pregnane X receptor (PXR) is the molecular target for a wide variety of endogenous and ...
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(Master thesis / Hovedoppgave, 2007)Peroksisom proliferator-aktivert reseptor a (PPARa) har en sentral rolle i regulering av uttrykk av lever-spesifikke gener. Da gallesyrer blir produsert fra kolesterol i leveren, og mange av enzymene involvert i deres ...
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(Master thesis / Hovedoppgave, 2004)The disagreement between various immunoassays for the tumour marker carcinoembryonic antigen (CEA) is well known, and the discrepancies are explained by the co-measurement of the structurally related non-specific cross-reacting ...
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(Master thesis / Masteroppgave, 2005)NUCKS-proteinet ble oppdaget i 1985 av Anne Carine Østvold og hennes medarbeidere ved Biokjemisk Institutt, Universitetet i Oslo. NUCKS genet er klonet og proteinet nøye karakterisert, men dets biologiske funksjon er ...
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(Master thesis / Masteroppgave, 2012)Ribonucleotide reductase (RNR) catalyses the reduction of the four ribonucleotides to their corresponding deoxyribonucleotides needed for synthesis and repair of DNA. RNR is found in the genome of all living organisms, ...
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(Master thesis / Masteroppgave, 2010)A highly conserved RNA-motif, called stem-loop-2-motif (s2m), has been identified in the 3' end of the genomes of viruses belonging to different RNA virus families which infect a broad range of animal species. Currently, ...
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(Master thesis / Hovedoppgave, 2006)Epitelcellelinjen ”Madin-Darby canine kidney” (MDCK), er en velstudert polarisert cellelinje som danner et tett cellelag med separate apikale og basolaterale membranoverflater. For å opprettholde polariteten, må nysyntetiserte ...