Search
Now showing items 101-200 of 2799
(Doctoral thesis / Doktoravhandling, 2008)
Appropriate T cell signaling is essential for the function of the human immune system. T cells regulate and direct the body’s response to foreign pathogens such as virus and bacteria, or threats from within in the form of ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
The establishment of the Determinants of Diet and Physical Activity (DEDIPAC) Knowledge Hub, 2013–2016, was the first action taken by the ‘Healthy Diet for a Healthy Life’ European Joint Programming Initiative. DEDIPAC ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Background: To compare pregnancy complications and birth outcomes for women experiencing nausea and vomiting in pregnancy, or nausea only, with symptom-free women.
Methods: Pregnancies from the Norwegian Mother and Child ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
The concept of foetal programming (FP) originated from human epidemiological studies, where foetal life nutrition was linked to health and disease status later in life. Since the proposal of this phenomenon, it has been ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
The effects of rickets on children recovery from severe acute malnutrition (SAM) are unknown. Rickets may affect both growth and susceptibility to infectious diseases. We investigated the associations of clinically diagnosed ...
(Doctoral thesis / Doktoravhandling, 2017)
Metabolic syndrome (MetS) is a cluster of risk factors for cardiovascular disease that include abdominal obesity, dyslipidemia, hyperglycemia and hypertension. Fish consumption may be a useful component when aiming to ...
(Doctoral thesis / Doktoravhandling, 2018)
A major challenge for understanding the brain in health and disease is related to combining information about the brain from many different sources. Spatial analysis and comparison of 2D and 3D brain images with the aim ...
(Doctoral thesis / Doktoravhandling, 2008)
Neurons conduct electrical signals, and signals pass from one neuron to the next by the use of chemical substances in specialized contacts, synapses. In most synapses, the transmitter is the amino acid glutamate. <br>
A ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background & aims: The effect of lycopene-containing foods in prostate cancer development remains undetermined. We tested whether a lycopene-rich tomato intervention could reduce the levels of prostate specific antigen ...
(Doctoral thesis / Doktoravhandling, 2016)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background & aims: Bioelectrical impedance analysis (BIA) is an accessible and cheap method to measure fat-free mass (FFM). However, BIA estimates are subject to uncertainty in patient populations with altered body composition ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
The most recent systematic literature reviews and meta-analyses have indicated significant and nutritionally-relevant composition differences between organic and conventional foods. This included higher antioxidant, but ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
A resurgence has taken place in recent years in the use of the extracellularly recorded local field potential (LFP) to investigate neural network activity. To probe monosynaptic thalamic activation of cortical postsynaptic ...
(Doctoral thesis / Doktoravhandling, 2012)
(Doctoral thesis / Doktoravhandling, 2022)
Human adipose tissue depots are physiologically different, with distinct metabolic properties and contributions to disease. The underlying mechanisms for these differences are yet to be uncovered. Large-scale transcriptomic ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
This study assessed the prevalence and risk factors associated with underweight, stunting and wasting among children aged 0–24 months in six districts of Kilimanjaro region, northern Tanzania. A cross-sectional population-based ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
NutritionDay is a yearly point-prevalence study of malnutrition in hospitals from more than 50 countries. The aim of the present study was to quantify the frequency of malnutrition and the proportion of malnourished patients ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Background
Innovations for undernourished pregnant women that improve newborn survival and anthropometry are needed to achieve the Sustainable Development Goals 1 and 3. This study tested the hypothesis that a combination ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Background
World Health Organization (WHO) recommends exclusive breastfeeding (EBF) as the optimal way to feed infants below 6 months of age. The benefits of EBF are well documented. However, in Tanzania, ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
The world is continuously urbanising, resulting in clusters of densely populated urban areas and more sparsely populated rural areas. We propose a method for generating spatial fields with controllable levels of clustering ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Background
More than one third of Norwegian women and men between 20 and 40 years of age have elevated cholesterol concentration. Parental metabolic health around conception or during pregnancy may affect ...
(Doctoral thesis / Doktoravhandling, 2020)
Pharmacogenomic screens for personalized cancer therapy are the focused biomedical application in this thesis. Due to the complex relationships between targeted cancer drugs and high-dimensional genomic predictors, we have ...
(Doctoral thesis / Doktoravhandling, 2008)
In observational epidemiology many studies rely on self-reported exposure information, which is prone to measurement errors and missing values. This may subsequently lead to bias in relative risk estimates of disease or ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Gaussian graphical models are useful tools for exploring network structures in multivariate normal data. In this paper we are interested in situations where data show departures from Gaussianity, therefore requiring ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background: Thought field therapy (TFT) is used for many psychiatric conditions, but its efficacy has not been sufficiently documented. Hence, there is a need for studies comparing TFT to well-established treatments. This ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Background
Dietary fat is an essential macronutrient. However, saturated fact has been associated with negative health outcomes including cardiovascular disease. Shifting consumption from saturated fat to ...
(Journal article / Tidsskriftartikkel / SubmittedVersion, 2017)
Context
Quality of life (QoL) and depression are important patient-reported outcomes in cancer care. However, the relative importance of depression severity in predicting QoL remains unclear because of few methodologically ...
(Doctoral thesis / Doktoravhandling, 2010)
The present thesis aims to contribute to a better understanding of the mechanisms underlying the development of long-lasting pain.
Animal models of long-term potentiation (LTP) induced by noxious stimuli are extensively ...
(Doctoral thesis / Doktoravhandling, 2009)
Regulering av PP1 og Nuklein syre binding av AKAP149 og PNUTS.<br><br>
Det er estimert at 1 av 8,000 har en sykdom som konsekvens av induserte mutasjoner som påvirker mitokondrienes funksjon eller prosesser, og mitokondriell ...
(Doctoral thesis / Doktoravhandling, 2010)
DNA damage responses are important both in the development and treatment of cancers. The main focus of the present thesis has been to explore whether the level of the second messenger cAMP can affect the cell’s response ...
(Doctoral thesis / Doktoravhandling, 2012)
(Doctoral thesis / Doktoravhandling, 2010)
Several studies have shown that there is a relatively high prevalence of burnout and mental distress among working physicians. This is an issue of concern, not only for the individual physician, but also in relation to ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
Background: Knowledge about the user’ needs is important to develop targeted rehabilitation for cancer patients with chronic fatigue (CF). The aims of the study were to examine prevalence of CF in cancer survivors attending ...
(Doctoral thesis / Doktoravhandling, 2012)
Background: During the last decades there has been a shift away from the traditional view of health care professionals as the only experts and providers of knowledge and the patients as passive recipients, to a more ...
(Doctoral thesis / Doktoravhandling, 2012)
(Doctoral thesis / Doktoravhandling, 2011)
Patients who suffer from leukemia or lymphoma can be cured by the transplantation of bone marrow stem cells from a volunteer donor (allogeneic hematopoietic cell transplantation). Recipients frequently acquire an immune ...
(Doctoral thesis / Doktoravhandling, 2011)
(Doctoral thesis / Doktoravhandling, 2013)
Having some understanding about genes and genetics can be important in many aspects of life, from taking part in political debates on scientific matters, to making personal choices about genetically modified foods, ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
The long-term cholesterol lowering effect of replacing intake of saturated fatty acids (SFAs) with polyunsaturated fatty acids (PUFAs) is well established, however not fully explained mechanistically. We examined the ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background
A premalignant lesion in the breast is associated with an increased risk of breast cancer. The aim of this article was to identify women with an increased risk of breast cancer based on prior screening results ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Three-dimensional digital brain atlases represent an important new generation of neuroinformatics tools for understanding complex brain anatomy, assigning location to experimental data, and planning of experiments. We have ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2008)
Cerebrovascular pathology is closely coupled to cognitive function decline, as indicated by numerous studies at the system level. To better understand the mechanisms of this cognitive decline it is important to resolve how ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)
The immense increase in the generation of genomic scale data poses an unmet analytical challenge, due to a lack of established methodology with the required flexibility and power. We propose a first principled approach to ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Background
Higher education is responsible for providing education that meets international benchmarks relevant to the needs of the international community. Due to the increase of digital tools in higher ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
(Doctoral thesis / Doktoravhandling, 2021)
Cutaneous melanoma is the most rapidly growing malignancy in Norway and is becoming an increasing public health concern. While exposure to ultraviolet radiation (UVR) from the sun and solarium is the primary risk factor, ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
Background
We lack national and cross-national studies of physicians’ perceptions of quality of patient care, professional autonomy, and job satisfaction to inform clinicians and policymakers. This study ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
α2-adrenoceptors (AR) lower central sympathetic output and peripheral catecholamine release, thereby protecting against sympathetic hyperactivity and hypertension. Norepinephrine re-uptake–transporter effectively (NET) ...
(Doctoral thesis / Doktoravhandling, 2021)
One in eleven women in Norway will be diagnosed with breast cancer by age 75. Organized mammographic screening can detect early stage breast cancer and reduce deaths from this disease. However, screening involves harms, ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
3',5'-cyclic adenosine monophosphate (cAMP) dependent protein kinase or protein kinase A (PKA) has served as a prototype for the large family of protein kinases that are crucially important for signal transduction in ...
(Doctoral thesis / Doktoravhandling, 2019)
The hazard rate is the most commonly studied parameter in survival analysis, but it is usually not suitable for causal inference.
This thesis focuses on developing alternatives to hazards for analyzing survival data. ...
(Doctoral thesis / Doktoravhandling, 2008)
Det er store forskjeller i kronisk underernæring og spedbarnsdødelighet mellom barn av urfolk og andre barn på det amerikanske kontinentet. Både underernæring og kroniske ernæringsrelaterte sykdommer rammer urfolk spesielt ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Background
Several ingredients in personal care products (PCPs) have been classified as endocrine disruptors (EDs) and concern has been raised whether use of PCPs can affect human health. We aimed to ...
(Journal article / Tidsskriftartikkel / SubmittedVersion, 2016)
Background Familial hypercholesterolaemia increases the risk for cardiovascular disease. The primary aim of the present study was to describe sex differences in incidence and prevalence of cardiovascular disease leading ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)
Aims: Despite the excess mortality and morbidity associated with acute poisoning by substances of abuse, follow-up is frequently not organised. We assessed morbidity, including repeated poisoning, and follow-up after acute ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Background & Aims: Liver fibrogenesis – scarring of the liver that can lead to cirrhosis and liver cancer – is characterized by hepatocyte impairment, capillarization of liver sinusoidal endothelial cells (LSECs) and hepatic ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Multiple sclerosis (MS) is a complex disease with many different immune cells involved in its pathogenesis, and in particular T cells as the most recognized cell type. Recently, the innate immune system has also been ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Aims/objective: We aimed to assess the long-term effects of post-transplant glycaemia on long-term survival after renal transplantation.
Methods: Study participants were 1,410 consecutive transplant recipients without ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Background Untreated patients with familial hypercholesterolemia are at increased risk of premature cardiovascular death. The primary aim of this study was to investigate whether this is also the case in the statin ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
Objective To investigate healthcare utilisation, induced labour and caesarean section (CS) in the pregnancy after stillbirth and assess anxiety and dread of childbirth as mediators for these outcomes.
Design Population-based ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Histone variant H3.3 is deposited in chromatin at active sites, telomeres, and pericentric heterochromatin by distinct chaperones, but the mechanisms of regulation and coordination of chaperone-mediated H3.3 loading remain ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Background
Procedures for the clinical assessment of acute poisoning by substances of abuse should identify patients in need of hospital admission and avoid hazardous discharges, while keeping the observation ...
(Doctoral thesis / Doktoravhandling, 2014)
The global obesity epidemic represents an enormous potential threat to public health, because overweight and obesity are major risk factors of non-communicable diseases. The prevalence of overweight has furthermore increased ...
(Doctoral thesis / Doktoravhandling, 2020)
Background: About 30% of patients in hospitals are malnourished or at risk of malnutrition. Malnutrition is associated with increased morbidity, longer convalescence, prolonged length of hospital stay, higher readmission ...
(Doctoral thesis / Doktoravhandling, 2010)
The live birth of cloned animals has shown that somatic cells are not irrevesibly committed to their fate. A functional reprogramming of differentiated cells to pluripotency may present beneficial applications in regenerative ...
(Journal article / Tidsskriftartikkel / SubmittedVersion, 2016)
The aim of this cross-sectional study was to investigate whether under-reporting of energy intake affects derived dietary patterns and the association between dietary patterns and self-reported chronic disease. Diets of ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
A number of studies have examined dietary patterns in various populations. However, to study to what extent such patterns capture meaningful differences in consumption of foods is of interest. In the present study, we ...
(Doctoral thesis / Doktoravhandling, 2019)
Spinal cord injury leads to a rapid and profound loss of skeletal muscle mass. Muscle atrophy consequently promotes metabolic disturbances and leads to increased risk of type 2 diabetes and cardiovascular disease. Prevention ...
(Doctoral thesis / Doktoravhandling, 2015)
Glutamatergic and GABAergic gliotransmission is a compilation of studies on the ability of glial cells to release glutamate by exocytosis and GABA by bestrophin 1 channel.
The vesicular glutamate transporters (VGLUTs) are ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Proteoglycans are fundamental components of the endothelial barrier, but the functions of the proteoglycan serglycin in endothelium are less described. Our aim was to describe the roles of serglycin in processes relevant ...
(Doctoral thesis / Doktoravhandling, 2016)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
High mammographic density (MD) is associated with a 4–6 times increase in breast cancer risk. For post-menopausal women, MD often decreases over time, but little is known about the underlying biological mechanisms. MD ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
Background
Progressive encephalopathy (PE) in children is a heterogeneous group of diseases mainly composed of metabolic diseases, but it consists also of neurodegenerative disorders where neither metabolic ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
Background
The Doloplus-2 is used for behavioural pain assessment in cognitively impaired patients. Little data exists on the psychometric properties of the Doloplus-2. Our objectives were to test the ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)
Background
Previous research on mental health care has shown considerable differences in use of seclusion, restraint and involuntary medication among different wards and geographical areas. This study ...
Plasma levels of leptin and mammographic density among postmenopausal women: a cross-sectional study
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2006)
Introduction
Obesity has been linked to increased risk of breast cancer in postmenopausal women. Increased peripheral production of estrogens has been regarded as the main cause for this association, but ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2006)
Background
Police work is regarded as a high-stress occupation, but so far, no nationwide study has explored the associations between work stress and health.
...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background
The number of events per individual is a widely reported variable in medical research papers. Such variables are the most common representation of the general variable type called discrete ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2008)
Background
Epidermal Growth Factor Receptor (EGFR) is a key target molecule in current treatment of several neoplastic diseases. Hence, in order to develop and improve current drugs targeting EGFR signalling, ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background
This paper studies the effect of mosquito abundance and malaria incidence in the last 3 weeks, and their interaction, on the hazard of time to malaria in a previously studied cohort of children ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Background
Food/drinks available to adolescents in schools can influence their dietary behaviours, which once established in adolescence, tend to remain over time. Food outlets’ influence near schools, known ...
(Doctoral thesis / Doktoravhandling, 2020)
Ischemic heart disease and myocardial infarction increase the risk of fatal heart failure via adverse myocardial remodeling. Cardiac cell death during myocardial infarction results in release of pro-inflammatory factors ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Background
The role of n-3 polyunsaturated fatty acids (PUFAs) in breast cancer is not clear and under debate. To explore this relationship it is important to have proper validated dietary assessment methods ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2014)
Purpose: To identify genes predicting benefit of radiotherapy in patients with high-risk breast cancer treated with systemic therapy and randomized to receive or not receive postmastectomy radiotherapy (PMRT). Experimental ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Dynamical downscaling of earth system models is intended to produce high-resolution climate information at regional to local scales. Current models, while adequate for describing temperature distributions at relatively ...
(Doctoral thesis / Doktoravhandling, 2022)
Statins represent a cornerstone in the pharmacological prevention of coronary heart disease. Although safe and effective, many patients do not adhere to their treatment, most commonly due to self-perceived muscle side ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background
Generalised anxiety disorder (GAD) is a frequent and severe anxiety disorder among older adults. GAD increases the risk of developing other disorders such as depression and coronary heart disease. ...
(Doctoral thesis / Doktoravhandling, 2012)
Synaptic transmission requires packing of neurotransmitters into synaptic vesicles. The role of aspartate as a neurotransmitter has been debated for more than 30 years, as vesicular accumulation of aspartate has been ...
(Doctoral thesis / Doktoravhandling, 2018)
There is a global epidemic of obesity in children, partly because of unhealthy diets. Taste preferences are part of the foundation for diets, but have not previously been longitudinally investigated in preschoolers. This ...
(Doctoral thesis / Doktoravhandling, 2021)
Organ donor shortage is a global problem, and patients die every day waiting for a transplant. In the field of tissue engineering, a major aim is to grow functional organs and tissues in the lab. Often using the patient’s ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Background
Metabotyping is a novel concept to group metabolically similar individuals. Different metabotypes may respond differently to dietary interventions; hence, metabotyping may become an important ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2014)
We investigate the effect of measurement error on principal component analysis in the high‐dimensional setting. The effects of random, additive errors are characterized by the expectation and variance of the changes in the ...
(Doctoral thesis / Doktoravhandling, 2018)
Natural killer (NK) cells recognize and kill cancer cells and infected cells. How NK cells discriminate between cancer cells and normal cells is not fully known. In this thesis we have found that an activating receptor ...
(Doctoral thesis / Doktoravhandling, 2018)
Apotek velegnet for testing av hjerte-kar-risiko
Viktige risikofaktorer for hjerte- og karsykdommer, som høyt kolesterol, høyt blodtrykk og høyt blodsukker, gir sjeldent symptomer. Man må derfor sjekke seg for å vite sin ...
(Doctoral thesis / Doktoravhandling, 2021)
Despite clear health benefits and recommendations, consumption of vegetables in children remains far too low. Although many studies have focused on increasing vegetable intake by children aged up to 5 years, only a few ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Background
To examine whether delirium in hip fracture patients was associated with changes in the levels of amino acids and/or monoamine metabolites in cerebrospinal fluid (CSF) and serum.
...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
Replication-independent chromatin deposition of histone variant H3.3 is mediated by several chaperones. We report a multistep targeting of newly synthesized epitope-tagged H3.3 to chromatin via PML bodies. H3.3 is recruited ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The European Union (EU) initiative on the Digital Transformation of Health and Care (Digicare) aims to provide the conditions necessary for building a secure, flexible, and decentralized digital health infrastructure. ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background
The extent of post-mortem detection of specific psychoactive drugs may differ between countries, and may greatly influence the national death register’s classification of manner and cause of ...