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Now showing items 1-100 of 2794
(Doctoral thesis / Doktoravhandling, 2016)
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2016)
When measuring a range of genomic, epigenomic, and transcriptomic variables for the same tissue sample, an integrative approach to analysis can strengthen inference and lead to new insights. This is also the case when ...
(Doctoral thesis / Doktoravhandling, 2018)
Birth asphyxia can lead to hypoxic-ischaemic (HI) brain injury. A concomitant perinatal infection increases the risk of neurological sequelae. Hypothermia treatment (HT) is current standard treatment for birth asphyxia. ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
The most recent systematic literature reviews and meta-analyses have indicated significant and nutritionally-relevant composition differences between organic and conventional foods. This included higher antioxidant, but ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Background
Completing upper secondary education is associated with higher work participation and less health-related absence from work. Although these outcomes are closely interrelated, most studies focus ...
(Journal article / Tidsskriftartikkel / SubmittedVersion, 2018)
Taurine is regarded as an essential amino acid in utero, and fetal taurine supply is believed to rely solely on placental transfer from maternal plasma. Despite its potential role in intrauterine growth restriction and ...
(Doctoral thesis / Doktoravhandling, 2019)
This thesis develops and exploits methodology within network science, driven by important applications. By use of large-scale simulations and high-quality data, we demonstrate how network science can contribute to understanding ...
(Doctoral thesis / Doktoravhandling, 2008)
Appropriate T cell signaling is essential for the function of the human immune system. T cells regulate and direct the body’s response to foreign pathogens such as virus and bacteria, or threats from within in the form of ...
(Doctoral thesis / Doktoravhandling, 2008)
Neurons conduct electrical signals, and signals pass from one neuron to the next by the use of chemical substances in specialized contacts, synapses. In most synapses, the transmitter is the amino acid glutamate. <br>
A ...
(Doctoral thesis / Doktoravhandling, 2017)
Metabolic syndrome (MetS) is a cluster of risk factors for cardiovascular disease that include abdominal obesity, dyslipidemia, hyperglycemia and hypertension. Fish consumption may be a useful component when aiming to ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background & aims: The effect of lycopene-containing foods in prostate cancer development remains undetermined. We tested whether a lycopene-rich tomato intervention could reduce the levels of prostate specific antigen ...
(Doctoral thesis / Doktoravhandling, 2018)
A major challenge for understanding the brain in health and disease is related to combining information about the brain from many different sources. Spatial analysis and comparison of 2D and 3D brain images with the aim ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
The effects of rickets on children recovery from severe acute malnutrition (SAM) are unknown. Rickets may affect both growth and susceptibility to infectious diseases. We investigated the associations of clinically diagnosed ...
(Doctoral thesis / Doktoravhandling, 2022)
Human adipose tissue depots are physiologically different, with distinct metabolic properties and contributions to disease. The underlying mechanisms for these differences are yet to be uncovered. Large-scale transcriptomic ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
The concept of foetal programming (FP) originated from human epidemiological studies, where foetal life nutrition was linked to health and disease status later in life. Since the proposal of this phenomenon, it has been ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Background: To compare pregnancy complications and birth outcomes for women experiencing nausea and vomiting in pregnancy, or nausea only, with symptom-free women.
Methods: Pregnancies from the Norwegian Mother and Child ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
This study assessed the prevalence and risk factors associated with underweight, stunting and wasting among children aged 0–24 months in six districts of Kilimanjaro region, northern Tanzania. A cross-sectional population-based ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
The establishment of the Determinants of Diet and Physical Activity (DEDIPAC) Knowledge Hub, 2013–2016, was the first action taken by the ‘Healthy Diet for a Healthy Life’ European Joint Programming Initiative. DEDIPAC ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
A resurgence has taken place in recent years in the use of the extracellularly recorded local field potential (LFP) to investigate neural network activity. To probe monosynaptic thalamic activation of cortical postsynaptic ...
(Doctoral thesis / Doktoravhandling, 2012)
(Doctoral thesis / Doktoravhandling, 2016)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background & aims: Bioelectrical impedance analysis (BIA) is an accessible and cheap method to measure fat-free mass (FFM). However, BIA estimates are subject to uncertainty in patient populations with altered body composition ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
NutritionDay is a yearly point-prevalence study of malnutrition in hospitals from more than 50 countries. The aim of the present study was to quantify the frequency of malnutrition and the proportion of malnourished patients ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Background
World Health Organization (WHO) recommends exclusive breastfeeding (EBF) as the optimal way to feed infants below 6 months of age. The benefits of EBF are well documented. However, in Tanzania, ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Background
Innovations for undernourished pregnant women that improve newborn survival and anthropometry are needed to achieve the Sustainable Development Goals 1 and 3. This study tested the hypothesis that a combination ...
(Doctoral thesis / Doktoravhandling, 2008)
In observational epidemiology many studies rely on self-reported exposure information, which is prone to measurement errors and missing values. This may subsequently lead to bias in relative risk estimates of disease or ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
The world is continuously urbanising, resulting in clusters of densely populated urban areas and more sparsely populated rural areas. We propose a method for generating spatial fields with controllable levels of clustering ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Gaussian graphical models are useful tools for exploring network structures in multivariate normal data. In this paper we are interested in situations where data show departures from Gaussianity, therefore requiring ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Background
More than one third of Norwegian women and men between 20 and 40 years of age have elevated cholesterol concentration. Parental metabolic health around conception or during pregnancy may affect ...
(Doctoral thesis / Doktoravhandling, 2020)
Pharmacogenomic screens for personalized cancer therapy are the focused biomedical application in this thesis. Due to the complex relationships between targeted cancer drugs and high-dimensional genomic predictors, we have ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background: Thought field therapy (TFT) is used for many psychiatric conditions, but its efficacy has not been sufficiently documented. Hence, there is a need for studies comparing TFT to well-established treatments. This ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background
National guidelines emphasize healthy eating to promote wellbeing and prevention of non-communicable diseases. The perceived healthiness of food is determined by many factors affecting food ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Atlases of the rat brain are widely used as reference for orientation, planning of experiments, and as tools for assigning location to experimental data. Improved quality and use of magnetic resonance imaging (MRI) and ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Nutrigenetic research examines the effects of inter-individual differences in genotype on responses to nutrients and other food components, in the context of health and of nutrient requirements. A practical application of ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background
Beyond survival of nowadays >80%, modern childhood cancer treatment strives to preserve long-term health and quality of life. However, the majority of today’s survivors suffer from short- and ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
To validate estimated intakes of carotenoid-rich foods from a web-based food recall (WebFR) using carotenoids in blood as an objective reference method.
Cross-sectional validation study using carotenoids in plasma to ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Background
A wide range of diseases show some degree of clustering in families; family history is therefore an important aspect for clinicians when making risk predictions. Familial aggregation is often ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background
The phenotypic stability of mixed connective tissue disease (MCTD) is not clear, and knowledge about disease activity and remission is scarce. We aimed to establish the occurrence of evolution ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Long-term impact of intrauterine fetal death on quality of life and depression: a case–control study
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
Background
Intrauterine fetal death (IUFD) is a serious incidence that has been shown to impact mothers’ psychological well-being in the short-term. Long-term quality of life (QOL) and depression after IUFD ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Background: Signalling proteins often contain several well defined and conserved protein domains. Structural analyses of such domains by nuclear magnetic spectroscopy or X-ray crystallography may greatly inform the function ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
Objectives: (1) To investigate the experiences of women with a previous stillbirth and their appraisal of the care they received at the hospital. (2) To assess the long-term level of post-traumatic stress symptoms (PTSS) ...
(Doctoral thesis / Doktoravhandling, 2010)
Over the past decades many western countries have witnessed an epidemic rise in obesity, insulin resistance and type 2 diabetes. There clearly is a link between increased fat storage and decreased insulin sensitivity leading ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Background
Diet has a great impact on the risk of developing features of metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM), and cardiovascular diseases (CVD). We evaluated whether a long-term ...
(Master thesis / Masteroppgave, 2009)
Regular physical activity has beneficial effects on health. The relations between exercise and health are not fully understood. Myokines are secretory peptides of skeletal muscle origin with auto-, para- or endocrine ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
Background Recent studies suggest that lactation has long-term effects on risk for cardiovascular disease in women, but the effects on cardiovascular mortality are less well known. Method In a Norwegian population-based ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Objective: Examine responses given to questions addressing whether pregnancy had caused women with nausea and vomiting (NVP) or symptom-free (SF) to alter their food habits in the first trimester in order to better understand ...
(Doctoral thesis / Doktoravhandling, 2018)
På samme måte som søppel dannes fra vårt daglige forbruk, produserer cellene i kroppen vår avfallsprodukter som transporteres til cellens resykleringsstasjon (lysosomet), hvor det brytes ned og gjenvinnes. Dette skjer via ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
The purpose of this study was to validate estimated energy intake from a web-based food recall, designed for children and adolescents. We directly compared energy intake to estimates of total energy expenditure, calculated ...
(Doctoral thesis / Doktoravhandling, 2008)
I fire vitenskaplige arbeider, har vi studert data fra det Norske mammografi programmet (brystkreft screening programmet), med moderne statistiske metoder og kraftige datamaskiner. I det første arbeidet ser vi at risikoen ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
Intercellular communication is pivotal in optimizing and synchronizing cellular responses to keep homeostasis and to respond adequately to external stimuli. In the central nervous system (CNS), glutamatergic and GABAergic ...
(Doctoral thesis / Doktoravhandling, 2007)
Chronic fatigue syndrome (CFS) is a disabling disease with unknown pathophysiology, but recent evidence suggests autonomic dysfunction. We have therefore explored cardiovascular and thermoregulatory autonomic responses. ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Background
More than 14 % of Ugandan children are orphaned and many live in children’s homes. Ugandan authorities have targeted adolescent girls as a priority group for nutrition interventions as safeguarding ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Background
Fish consumption may prevent or improve metabolic health. The aim of this study was to identify associations between fish consumption, both fatty and lean, and metabolic syndrome and its ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Background
Early adulthood is a period associated with poor diet and rapid weight gain. This is also an age of transition, including environmental, social and lifestyle changes which may be associated with ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background
Policy frameworks focusing on policy implementation may vary in terms of their scope, included constructs, relationships between the constructs, and context factors. Although multiple policy ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Background
Doctor –certified sick leave is prevalent in the health and social sector. We examined whether the higher risk of doctor-certified sick leave in women in health and social occupations compared ...
(Doctoral thesis / Doktoravhandling, 2016)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Background
Fish consumption may have a role in reducing the prevalence of metabolic syndrome (MetS). The aim of this study was to identify associations between fish consumption and MetS and its components, ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Background
Understanding the determinants associated with prediabetes and type 2 diabetes in coronary patients may help to individualize treatment and modelling interventions. We sought to identify ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Background
The endovascular treatment procedure in tandem occlusions (TO) is complex compared to single occlusion (SO) and optimal management remains uncertain. The aim of this study was to identify clinical ...
(Doctoral thesis / Doktoravhandling, 2016)
GABA and glutamate transporter proteins are important in relation to epilepsy because they represent the mechanisms that keep the extracellular concentrations of GABA and dicarboxylic amino acids low. GABA and glutamate ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Background
Multi-item rating scales for depression informs about the level of depression, but does not allow individuals to state by self-evaluation whether they feel depressed or not. The insider perspective ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
The comet assay has developed over the past 30 years and today, a variety of different DNA lesions and DNA repair can be measured by different versions of the assay (Collins, 2004). In the final step of the method, an image ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
Patients’ knowledge about psoriasis and its treatment has been randomly studied previously. The aim of the study is to investigate patients’ knowledge about psoriasis in relation to undergoing patient education in the ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Background Fruit and vegetable intake has been found to reduce the risk of cardiovascular disease, certain types of cancer and diabetes mellitus. It is possible that antioxidants play a large part in this protective effect. ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Genome-wide sequencing technologies enable investigations of the structural properties of the genome in various spatial dimensions. Here, we review computational techniques developed to model the three-dimensional genome ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background
Previous studies suggest that persistent exposure to social stress in mammals may be associated with multiple physiological effects. Here, we examine the effects of social stress in rats, i.e. repeated social ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
α2-adrenoceptor-activation lowers central sympathetic output, peripheral, vesicular norepinephrine release, epinephrine secretion and modulates vascular tension. We previously demonstrated that α2-adrenoceptor-mediated ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
α2-Adrenoceptors lower central sympathetic output and peripheral catecholamine release, and thus may prevent sympathetic hyperactivity and hypertension. α2AR also influence vascular tension. These α2AR are malfunctioning ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Peripheral norepinephrine release is facilitated by presynaptic β-adrenoceptors (AR), believed to involve the β2-subtype exclusively. However, β1-selective blockers are the most commonly used β-blockers in hypertension. ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Sympathetic hyperactivity and parasympathetic insufficiency characterize blood pressure (BP) control in genetic hypertension. This shift is difficult to investigate in anesthetized rats. Here we present a pharmacological ...
(Doctoral thesis / Doktoravhandling, 2015)
The thesis describes the electrical activity in nerve cells (motoneurons) that control the deep back muscles in humans. The experiments were conducted using thin wire electrodes that were implanted deep in the spinal muscles ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2005)
RNA interference (RNAi) has become an invaluable tool for functional genomics. A critical use of this tool depends on an understanding of the factors that determine the specificity and activity of the active agent, small ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Biomarkers of nutrient intake or nutrient status are important objective measures of foods/nutrients as one of the most important environmental factors people are exposed to. It is very difficult to obtain accurate data ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
Background Few studies have focused on fatigue in myasthenia gravis (MG), and fatigue in relation to the autonomic system has never been systematically explored in these patients. The study aimed to document the prevalence ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
The system N transporter SN1 (also known as SNAT3) is enriched on perisynaptic astroglial cell membranes. SN1 mediates electroneutral and bidirectional glutamine transport, and regulates the intracellular as well as the ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Knowledge of illness perception may aid the identification of groups of patients with a higher risk of coping
poorly with the demands of their illness. This study aims to investigate associations between illness perception, ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Here, the influence of β3-adrenoceptors on catecholamine release in normotensive and spontaneously hypertensive rats was analyzed. Blood pressure was recorded through a femoral artery catheter, and cardiac output by ascending ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Background: Cobalamin and folate are essential micronutrients and are important in DNA and RNA synthesis, cell proliferation, growth, hematopoiesis, and cognitive function. However, data on cobalamin and folate status are ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2016)
Background Changes in electroencephalography (EEG) voltage range are used to monitor the depth of anaesthesia, as well as predict outcome after hypoxia-ischaemia in neonates. Xenon is being investigated as a potential ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Neonatal hypoxic‐ischemic encephalopathy (HIE) is associated with alterations in cerebral blood flow (CBF) as a result of perinatal asphyxia. The extent to which CBF changes contribute to injury, and whether treatments ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Objective In women, the risk for non-communicable diseases increases after menopause. We aimed to identify major dietary patterns and study their associations with nutrient intake, sociodemographic factors and risk factors ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Background: Compared to food patterns, nutrient patterns have been rarely used particularly at international level. We studied, in the context of a multi-center study with heterogeneous data, the methodological challenges ...
(Doctoral thesis / Doktoravhandling, 2017)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background
Lack of Hepatitis C virus (HCV) incidence data in (Norwegian) high-risk groups impedes the ability to make informed decisions on prevention measures. Thus we rely on modelling to estimate the ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
In the dairy breeding industry, prediction of bull fertility in artificial insemination (AI) is important for efficient and economically sustainable production. However, it is challenging to identify bulls with superior ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2014)
Blood pressure is a critical determinant of cardiovascular morbidity and mortality. It is affected by environmental factors, but has a strong heritable component. Despite recent large genome-wide association studies, few ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
The three-dimensional (3D) structure of the genome is important for orchestration of gene expression and cell differentiation. While mapping genomes in 3D has for a long time been elusive, recent adaptations of high-throughput ...
(Doctoral thesis / Doktoravhandling, 2020)
The three-dimensional (3D) organization of chromatin in the mammalian cell nucleus plays an important role in the regulation of gene expression. In her Ph.D. thesis, Anna Frida Forsberg has investigated the impact of ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
Objective: Neurocognitive impairment is commonly reported at onset of psychotic disorders. However, the long-term neurocognitive course remains largely uninvestigated in first episode psychosis (FEP) and the relationship ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
Background
This is a six-year prospective follow-up of a former cross sectional study of suicide attempters in a sample of treatment-seeking substance-dependent patients. The aims were to explore the frequency ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
Background
Communication training builds on the assumption that understanding of the concepts related to professional communication facilitates the training. We know little about whether students' knowledge ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background
Self-evaluations of mental health problems may be a useful complement to diagnostic assessment, but are less frequently used. This study investigated the prevalence of self-evaluated current and ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background
There is a lack of comprehensive patient-datasets regarding prevalence of severe hypertriglyceridemia (sHTG; triglycerides ≥10 mmol/L), frequency of co-morbidities, gene mutations, and gene ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2009)
Vaccines using dendritic cells (DCs) harboring leukemic antigens to stimulate T cells is a possible treatment of acute myeloid leukemia (AML). Limitations of breaking tolerance to leukemic cells and lack of specific ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Aquaporin-4 (AQP4) water channels are concentrated in astrocytic endfoot membranes at the brain–blood and brain–cerebrospinal fluid interfaces. The mechanisms underpinning the polarized distribution of AQP4 are poorly ...