Browsing Institutt for molekylær biovitenskap by Author "Lothe, Ragnhild A"

Now showing items 1-6 of 6

  • Comparison of chromosomal and array-based comparative genomic hybridization for the detection of genomic imbalances in primary prostate carcinomas 
    Ribeiro, Franclim R; Henrique, Rui; Hektoen, Merete; Berg, Marianne; Jerónimo, Carmen; Teixeira, Manuel R; Lothe, Ragnhild A (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2006)
    Background In order to gain new insights into the molecular mechanisms involved in prostate cancer, we performed array-based comparative genomic hybridization (aCGH) on a series of 46 primary prostate ...
  • Gene expression profiles of primary colorectal carcinomas, liver metastases, and carcinomatoses 
    Kleivi, Kristine; Lind, Guro E; Diep, Chieu B; Meling, Gunn I; Brandal, Lin T; Nesland, Jahn M; Myklebost, Ola; Rognum, Torleiv O; Giercksky, Karl-Erik; Skotheim, Rolf I; Lothe, Ragnhild A (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
    Background Despite the fact that metastases are the leading cause of colorectal cancer deaths, little is known about the underlying molecular changes in these advanced disease stages. Few have studied the ...
  • Gene methylation profiles of normal mucosa, and benign and malignant colorectal tumors identify early onset markers 
    Ahlquist, Terje; Lind, Guro E; Costa, Vera L; Meling, Gunn I; Vatn, Morten; Hoff, Geir S; Rognum, Torleiv O; Skotheim, Rolf I; Thiis-Evensen, Espen; Lothe, Ragnhild A (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2008)
    Background Multiple epigenetic and genetic changes have been reported in colorectal tumors, but few of these have clinical impact. This study aims to pinpoint epigenetic markers that can discriminate between ...
  • Hypermethylated MAL gene – a silent marker of early colon tumorigenesis 
    Lind, Guro E; Ahlquist, Terje; Kolberg, Matthias; Berg, Marianne; Eknæs, Mette; Alonso, Miguel A; Kallioniemi, Anne; Meling, Gunn I; Skotheim, Rolf I; Rognum, Torleiv O; Thiis-Evensen, Espen; Lothe, Ragnhild A (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2008)
    Background Tumor-derived aberrantly methylated DNA might serve as diagnostic biomarkers for cancer, but so far, few such markers have been identified. The aim of the present study was to investigate the ...
  • MDM2 antagonist Nutlin-3a potentiates antitumour activity of cytotoxic drugs in sarcoma cell lines 
    Ohnstad, Hege O; Paulsen, Erik B; Noordhuis, Paul; Berg, Marianne; Lothe, Ragnhild A; Vassilev, Lyubomir T; Myklebost, Ola (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
    Background Frequent failure and severe side effects of current sarcoma therapy warrants new therapeutic approaches. The small-molecule MDM2 antagonist Nutlin-3a activates the p53 pathway and efficiently ...
  • The loss of NKX3.1 expression in testicular – and prostate – cancers is not caused by promoter hypermethylation 
    Lind, Guro E; Skotheim, Rolf I; Fraga, Mario F; Abeler, Vera M; Henrique, Rui; Saatcioglu, Fahri; Esteller, Manel; Teixeira, Manuel R; Lothe, Ragnhild A (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2005)
    Background Recent studies have demonstrated that the NKX3.1 protein is commonly down-regulated in testicular germ cell tumors (TGCTs) and prostate carcinomas. The homeobox gene NKX3.1 maps to chromosome ...