dc.date.accessioned | 2013-03-12T09:10:08Z | |
dc.date.available | 2013-03-12T09:10:08Z | |
dc.date.issued | 2009 | en_US |
dc.date.submitted | 2009-07-29 | en_US |
dc.identifier.citation | Gamadeku, Thywill. Functionalization of the Purine 8-Position via 8-Lithiated Species: Scopes and Limitations. Masteroppgave, University of Oslo, 2009 | en_US |
dc.identifier.uri | http://hdl.handle.net/10852/12854 | |
dc.description.abstract | ABSTRACT
In this study, 6-chloropurines with varied substituents in the 2 and 9 or 7 positions were functionalized in the 8-position. This was done via lithiation and subsequent bromination to form 8-brominated purines.
It was observed that lithiation/bromination of N-9 benzylated purines bearing electron donating substituents on the phenyl ring gave good conversions and excellent yields of the expected 8-bromo purines. On the other hand, those bearing electron withdrawing groups on the phenyl ring gave poor conversions and yields of the expected 8-bromo purines.
Aside the expected 8-bromo purines, dimers and aldehydes were observed as by-products of this reaction. | eng |
dc.language.iso | eng | en_US |
dc.title | Functionalization of the Purine 8-Position via 8-Lithiated Species: Scopes and Limitations | en_US |
dc.type | Master thesis | en_US |
dc.date.updated | 2009-07-31 | en_US |
dc.creator.author | Gamadeku, Thywill | en_US |
dc.subject.nsi | VDP::440 | en_US |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft.au=Gamadeku, Thywill&rft.title=Functionalization of the Purine 8-Position via 8-Lithiated Species: Scopes and Limitations&rft.inst=University of Oslo&rft.date=2009&rft.degree=Masteroppgave | en_US |
dc.identifier.urn | URN:NBN:no-22607 | en_US |
dc.type.document | Masteroppgave | en_US |
dc.identifier.duo | 93692 | en_US |
dc.contributor.supervisor | Prof Lise-Lotte Gundersen | en_US |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/12854/1/thesis.pdf | |