dc.date.accessioned | 2013-03-12T08:56:37Z | |
dc.date.available | 2013-03-12T08:56:37Z | |
dc.date.issued | 2009 | en_US |
dc.date.submitted | 2009-06-15 | en_US |
dc.identifier.citation | Dohrn, Linda. Investigation of Alternative Methods for the Synthesis of 1,2,3-Triazole Analogues of Combretastatin A-1 and A-4 . Masteroppgave, University of Oslo, 2009 | en_US |
dc.identifier.uri | http://hdl.handle.net/10852/12307 | |
dc.description.abstract | 1,2,3- Triazole analoger av combretastatin A-4 har lovende og interessant inhibering av tubulin og viser cytotoksisk effekt i flere kreftcelle-linjer.
Slike triazoler kan dannes med en termal Huisgen cycloaddisjonsreaksjon eller med en magnesium katalysert metode. Begge metodene har ulemper; termal cycloaddisjon gir to regioisomerer og den magnesium katalysert reaksjonen er inkompatibel med flere funksjonelle grupper, slik som nitro-gruppen.
I denne masteroppgaven har alternative metoder for syntese av 1,2,3-triazole analoger av combretastatin A-1 og A-4 blitt undersøkt. I nærvær av tetra-ethyl ammonium hydroksid ble ønsket 1,5-disubstituert 1,2,3-triazole analoger fremstilt. | nor |
dc.description.abstract | 1,2,3-Triazole analogues of Combretastatin A-4 have interesting tubulin inhibition and cytotoxic effects against several cancer cell lines.
These triazoles were attained by either the thermal Huisgen cycloaddition reaction or by a magnesium catalyzed method. Both methods have disadvantages; thermal cycloaddition yields two regioisomers and the magnesium catalyzed reaction is intolerant with substituents, such as the nitro-group.
In this thesis alternative methods for the synthesis of 1,2,3-triazole analogues of Combretastatin A-1 and A-4 were investigated. In the presence of tetra-ethyl ammonium hydroxide the desired 1,5-disubstituted 1,2,3-triazole analogues were attained. | eng |
dc.language.iso | eng | en_US |
dc.subject | 1 | en_US |
dc.subject | 2 | en_US |
dc.subject | 3 | en_US |
dc.subject | -triazolesynteseoksygenfuktighetstolerantmaterialetriazole | en_US |
dc.title | Investigation of Alternative Methods for the Synthesis of 1,2,3-Triazole Analogues of Combretastatin A-1 and A-4 | en_US |
dc.type | Master thesis | en_US |
dc.date.updated | 2010-05-27 | en_US |
dc.creator.author | Dohrn, Linda | en_US |
dc.subject.nsi | VDP::568 | en_US |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft.au=Dohrn, Linda&rft.title= Investigation of Alternative Methods for the Synthesis of 1,2,3-Triazole Analogues of Combretastatin A-1 and A-4 &rft.inst=University of Oslo&rft.date=2009&rft.degree=Masteroppgave | en_US |
dc.identifier.urn | URN:NBN:no-24705 | en_US |
dc.type.document | Masteroppgave | en_US |
dc.identifier.duo | 92811 | en_US |
dc.contributor.supervisor | Trond Vidar Hansen | en_US |
dc.identifier.bibsys | 10115500x | en_US |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/12307/3/Dohrn_Linda_master.pdf | |