dc.date.accessioned | 2024-08-09T15:33:33Z | |
dc.date.available | 2024-08-09T15:33:33Z | |
dc.date.created | 2024-07-17T12:01:46Z | |
dc.date.issued | 2024 | |
dc.identifier.citation | Eriksson, Cecilia Magdalena Kirsebom, Bjørn-Eivind Seljelid Espenes, Ragna Siafarikas, Nikias Ioannis Waterloo, Knut Rongve, Arvid Selnes, Per Aarsland, Dag Fladby, Tormod Hessen, Erik . Depressive Symptoms Are Not Associated with Predementia Cerebrospinal Fluid Amyloid Pathology. Dementia and Geriatric Cognitive Disorders Extra. 2024, 14(1), 40-48 | |
dc.identifier.uri | http://hdl.handle.net/10852/111863 | |
dc.description.abstract | Introduction: Depressive symptoms are associated with Alzheimer’s disease (AD), but their neurobiological and neuropsychological correlates remain poorly understood. We investigate if depressive symptoms are associated with amyloid (Aβ) pathology and cognition in predementia AD. Methods: We included subjective cognitive decline (SCD, n = 160) and mild cognitive impairment (MCI, n = 192) from the dementia disease initiation cohort. Depressive symptoms were assessed using the Geriatric Depression Scale (GDS-15). Aβ pathology was determined using cerebrospinal fluid (CSF) Aβ42/40 ratio. Associations between depressive symptoms and cognition were assessed with logistic regression. Results: Only the Aβ negative MCI group (MCI-Aβ−) was associated with depressive symptoms (odds ratio [OR] = 2.65, p = 0.005). Depressive symptoms were associated with worse memory in MCI-Aβ− (OR = 0.94, p = 0.039), but with better performance in MCI-Aβ+ (OR = 1.103, p = 0.001). Conclusion: Our results suggest that depressive symptoms in MCI are neither associated with Aβ pathology, nor AD-associated memory impairment. However, memory impairment in non-AD MCI may relate to depressive symptoms. | |
dc.language | EN | |
dc.rights | Attribution-NonCommercial 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.title | Depressive Symptoms Are Not Associated with Predementia Cerebrospinal Fluid Amyloid Pathology | |
dc.title.alternative | ENEngelskEnglishDepressive Symptoms Are Not Associated with Predementia Cerebrospinal Fluid Amyloid Pathology | |
dc.type | Journal article | |
dc.creator.author | Eriksson, Cecilia Magdalena | |
dc.creator.author | Kirsebom, Bjørn-Eivind Seljelid | |
dc.creator.author | Espenes, Ragna | |
dc.creator.author | Siafarikas, Nikias Ioannis | |
dc.creator.author | Waterloo, Knut | |
dc.creator.author | Rongve, Arvid | |
dc.creator.author | Selnes, Per | |
dc.creator.author | Aarsland, Dag | |
dc.creator.author | Fladby, Tormod | |
dc.creator.author | Hessen, Erik | |
cristin.unitcode | 185,17,5,0 | |
cristin.unitname | Psykologisk institutt | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 2282531 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Dementia and Geriatric Cognitive Disorders Extra&rft.volume=14&rft.spage=40&rft.date=2024 | |
dc.identifier.jtitle | Dementia and Geriatric Cognitive Disorders Extra | |
dc.identifier.volume | 14 | |
dc.identifier.issue | 1 | |
dc.identifier.startpage | 40 | |
dc.identifier.endpage | 48 | |
dc.identifier.doi | https://doi.org/10.1159/000539284 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1664-5464 | |
dc.type.version | PublishedVersion | |