dc.date.accessioned | 2024-06-25T15:47:15Z | |
dc.date.available | 2024-06-25T15:47:15Z | |
dc.date.created | 2024-02-26T08:49:14Z | |
dc.date.issued | 2024 | |
dc.identifier.citation | Guo, Annie Ludvigsson, Johnny Brantsæter, Anne Lise Klingberg, Sofia Östensson, Malin Størdal, Ketil Mårild, Karl . Early-life diet and risk of inflammatory bowel disease: A pooled study in two Scandinavian birth cohorts. Gut. 2024, 73(4), 590-600 | |
dc.identifier.uri | http://hdl.handle.net/10852/111245 | |
dc.description.abstract | Objective We assessed whether early-life diet quality and food intake frequencies were associated with subsequent IBD.
Design Prospectively recorded 1-year and 3-year questionnaires in children from the All Babies in Southeast Sweden and The Norwegian Mother, Father and Child Cohort Study were used to assess diet quality using a Healthy Eating Index and intake frequency of food groups. IBD was defined as >2 diagnoses in national patient registers. Cox regression yielded HRs adjusted (aHRs) for child’s sex, parental IBD, origin, education level and maternal comorbidities. Cohort-specific results were pooled using a random-effects model.
Results During 1 304 433 person-years of follow-up, we followed 81 280 participants from birth through childhood and adolescence, whereof 307 were diagnosed with IBD. Compared with low diet quality, medium and high diet quality at 1 year of age were associated with a reduced risk of IBD (pooled aHR 0.75 (95% CI=0.58 to 0.98) and 0.75 (95% CI=0.56 to 1.00)). The pooled aHR per increase of category was 0.86 (0.74 to 0.99). Pooled aHR for children 1 year old with high versus low fish intake was 0.70 (95% CI=0.49 to 1.00) for IBD, and showed association with reduced risk of UC (pooled aHR=0.46; 95% CI=0.21, 0.99). Higher vegetable intake at 1 year was associated with a risk reduction in IBD. Intake of sugar-sweetened beverages was associated with an increased risk of IBD. Diet quality at 3 years was not associated with IBD.
Conclusion In this Scandinavian birth cohort, high diet quality and fish intake in early life were associated with a reduced risk of IBD. | |
dc.language | EN | |
dc.publisher | BMJ Publishing Group | |
dc.rights | Attribution-NonCommercial 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.title | Early-life diet and risk of inflammatory bowel disease: A pooled study in two Scandinavian birth cohorts | |
dc.title.alternative | ENEngelskEnglishEarly-life diet and risk of inflammatory bowel disease: A pooled study in two Scandinavian birth cohorts | |
dc.type | Journal article | |
dc.creator.author | Guo, Annie | |
dc.creator.author | Ludvigsson, Johnny | |
dc.creator.author | Brantsæter, Anne Lise | |
dc.creator.author | Klingberg, Sofia | |
dc.creator.author | Östensson, Malin | |
dc.creator.author | Størdal, Ketil | |
dc.creator.author | Mårild, Karl | |
cristin.unitcode | 185,53,46,1 | |
cristin.unitname | Forskningsleder BAR | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 2249612 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Gut&rft.volume=73&rft.spage=590&rft.date=2024 | |
dc.identifier.jtitle | Gut | |
dc.identifier.volume | 73 | |
dc.identifier.issue | 4 | |
dc.identifier.startpage | 590 | |
dc.identifier.endpage | 600 | |
dc.identifier.doi | https://doi.org/10.1136/gutjnl-2023-330971 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0017-5749 | |
dc.type.version | PublishedVersion | |