dc.date.accessioned | 2024-06-25T15:46:18Z | |
dc.date.available | 2024-06-25T15:46:18Z | |
dc.date.created | 2024-02-20T13:55:04Z | |
dc.date.issued | 2024 | |
dc.identifier.citation | Färdig, Martin Hoyer, Angela Almqvist, Catarina Bains, Karen Eline S. Carlsen, Karin C. Lødrup Gudmundsdottir, Hrefna Katrin Granum, Berit Haugen, Guttorm Nils Hedlin, Gunilla Jonassen, Christine Monceyron Konradsen, Jon R. Lie, Anine Rehbinder, Eva Maria Skjerven, Håvard O. Staff, Anne Cathrine Vettukattil, Muhammad Riyas Söderhäll, Cilla Nordlund, Bjørn Kristian . Infant lung function and early skin barrier impairment in the development of asthma at age 3 years. Allergy. European Journal of Allergy and Clinical Immunology. 2024, 79, 667-678 | |
dc.identifier.uri | http://hdl.handle.net/10852/111244 | |
dc.description.abstract | Background
Largely unexplored, we investigated if lower lung function, impaired skin barrier function by transepidermal water loss (TEWL), eczema, and filaggrin (FLG) mutations in infancy were associated with asthma in early childhood.
Methods
From the factorially designed randomized controlled intervention study PreventADALL, we evaluated 1337/2394 children from all randomization groups with information on asthma at age 3 years, and at age 3 months either lung function, TEWL, eczema, and/or FLG mutations. Lower lung function was defined as the time to peak tidal expiratory flow to expiratory time (tPTEF/tE) <0.25, and skin barrier impairment as a high TEWL >9.50 g/m2/h. Eczema was clinically observed, and DNA genotyped for FLG mutations. Asthma was defined as asthma-like symptoms (≥3 episodes of bronchial obstruction) between age 2–3 years as well as a history of doctor-diagnosed asthma and/or asthma medication use. Associations were analyzed in logistic regression models, presented with adjusted ORs (aOR) and 95% confidence intervals (CI).
Results
Lower lung function and skin barrier impairment were associated with asthma in general; aOR (95% CI) 5.4 (2.1, 13.7) and 1.6 (1.1, 2.5), while eczema and FLG mutations were associated with asthma in children with atopic dermatitis or allergic sensitization only. Stratifying for sex, the risk of asthma was only increased in boys with lower lung function; aOR (95% CI) 7.7 (2.5, 23.6), and in girls with FLG mutations; aOR (95% CI) 3.5 (1.5, 8.2).
Conclusion
Lower lung function and impaired skin barrier function in infancy may increase the risk of asthma at age 3 years. | |
dc.language | EN | |
dc.rights | Attribution-NonCommercial 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.title | Infant lung function and early skin barrier impairment in the development of asthma at age 3 years | |
dc.title.alternative | ENEngelskEnglishInfant lung function and early skin barrier impairment in the development of asthma at age 3 years | |
dc.type | Journal article | |
dc.creator.author | Färdig, Martin | |
dc.creator.author | Hoyer, Angela | |
dc.creator.author | Almqvist, Catarina | |
dc.creator.author | Bains, Karen Eline S. | |
dc.creator.author | Carlsen, Karin C. Lødrup | |
dc.creator.author | Gudmundsdottir, Hrefna Katrin | |
dc.creator.author | Granum, Berit | |
dc.creator.author | Haugen, Guttorm Nils | |
dc.creator.author | Hedlin, Gunilla | |
dc.creator.author | Jonassen, Christine Monceyron | |
dc.creator.author | Konradsen, Jon R. | |
dc.creator.author | Lie, Anine | |
dc.creator.author | Rehbinder, Eva Maria | |
dc.creator.author | Skjerven, Håvard O. | |
dc.creator.author | Staff, Anne Cathrine | |
dc.creator.author | Vettukattil, Muhammad Riyas | |
dc.creator.author | Söderhäll, Cilla | |
dc.creator.author | Nordlund, Bjørn Kristian | |
cristin.unitcode | 185,50,0,0 | |
cristin.unitname | Det medisinske fakultet | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 2248091 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Allergy. European Journal of Allergy and Clinical Immunology&rft.volume=79&rft.spage=667&rft.date=2024 | |
dc.identifier.jtitle | Allergy. European Journal of Allergy and Clinical Immunology | |
dc.identifier.volume | 79 | |
dc.identifier.issue | 3 | |
dc.identifier.startpage | 667 | |
dc.identifier.endpage | 678 | |
dc.identifier.doi | https://doi.org/10.1111/all.16024 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0105-4538 | |
dc.type.version | PublishedVersion | |