dc.date.accessioned | 2024-06-24T15:12:00Z | |
dc.date.available | 2024-06-24T15:12:00Z | |
dc.date.created | 2024-04-26T12:16:06Z | |
dc.date.issued | 2024 | |
dc.identifier.citation | Moksnes, Marta Riise Hansen, Ailin Falkmo Wolford, Brooke Thomas, Laurent Francois Rasheed, Humaira Simic, Anica Bhatta, Laxmi Brantsæter, Anne Lise Surakka, Ida Zhou, Wei Magnus, Per Minor Njølstad, Pål Rasmus Andreassen, Ole Syversen, Tore Zheng, Jie Fritsche, Lars Evans, David M. Warrington, Nicole Maree Nøst, Therese Haugdahl Åsvold, Bjørn Olav Flaten, Trond Peder Willer, Cristen J. Hveem, Kristian Brumpton, Ben Michael . A genome-wide association study provides insights into the genetic etiology of 57 essential and non-essential trace elements in humans. Communications Biology. 2024, 7(1) | |
dc.identifier.uri | http://hdl.handle.net/10852/111203 | |
dc.description.abstract | Trace elements are important for human health but may exert toxic or adverse effects. Mechanisms of uptake, distribution, metabolism, and excretion are partly under genetic control but have not yet been extensively mapped. Here we report a comprehensive multi-element genome-wide association study of 57 essential and non-essential trace elements. We perform genome-wide association meta-analyses of 14 trace elements in up to 6564 Scandinavian whole blood samples, and genome-wide association studies of 43 trace elements in up to 2819 samples measured only in the Trøndelag Health Study (HUNT). We identify 11 novel genetic loci associated with blood concentrations of arsenic, cadmium, manganese, selenium, and zinc in genome-wide association meta-analyses. In HUNT, several genome-wide significant loci are also indicated for other trace elements. Using two-sample Mendelian randomization, we find several indications of weak to moderate effects on health outcomes, the most precise being a weak harmful effect of increased zinc on prostate cancer. However, independent validation is needed. Our current understanding of trace element-associated genetic variants may help establish consequences of trace elements on human health. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | A genome-wide association study provides insights into the genetic etiology of 57 essential and non-essential trace elements in humans | |
dc.title.alternative | ENEngelskEnglishA genome-wide association study provides insights into the genetic etiology of 57 essential and non-essential trace elements in humans | |
dc.type | Journal article | |
dc.creator.author | Moksnes, Marta Riise | |
dc.creator.author | Hansen, Ailin Falkmo | |
dc.creator.author | Wolford, Brooke | |
dc.creator.author | Thomas, Laurent Francois | |
dc.creator.author | Rasheed, Humaira | |
dc.creator.author | Simic, Anica | |
dc.creator.author | Bhatta, Laxmi | |
dc.creator.author | Brantsæter, Anne Lise | |
dc.creator.author | Surakka, Ida | |
dc.creator.author | Zhou, Wei | |
dc.creator.author | Magnus, Per Minor | |
dc.creator.author | Njølstad, Pål Rasmus | |
dc.creator.author | Andreassen, Ole | |
dc.creator.author | Syversen, Tore | |
dc.creator.author | Zheng, Jie | |
dc.creator.author | Fritsche, Lars | |
dc.creator.author | Evans, David M. | |
dc.creator.author | Warrington, Nicole Maree | |
dc.creator.author | Nøst, Therese Haugdahl | |
dc.creator.author | Åsvold, Bjørn Olav | |
dc.creator.author | Flaten, Trond Peder | |
dc.creator.author | Willer, Cristen J. | |
dc.creator.author | Hveem, Kristian | |
dc.creator.author | Brumpton, Ben Michael | |
cristin.unitcode | 185,53,82,0 | |
cristin.unitname | Klinikk for indremedisin og lab fag | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 2264921 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Communications Biology&rft.volume=7&rft.spage=&rft.date=2024 | |
dc.identifier.jtitle | Communications Biology | |
dc.identifier.volume | 7 | |
dc.identifier.issue | 1 | |
dc.identifier.pagecount | 0 | |
dc.identifier.doi | https://doi.org/10.1038/s42003-024-06101-z | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2399-3642 | |
dc.type.version | PublishedVersion | |
cristin.articleid | 432 | |